Pegylated L-Asparaginase

PEGylated Erwinia L-asparaginase for treating diseases like cancer that are treatable by L-asparagine depletion. The L-asparaginase is from Erwinia chrysanthemi and conjugated to PEG with a molecular weight less than 5000 Da. The PEGylation improves pharmacological properties compared to unmodified L-asparaginase or pegaspargase. It depletes plasma L-asparagine to undetectable levels for longer durations and has higher potency. The PEGylated Erwinia L-asparaginase is useful as a therapeutic for treating diseases treatable by L-asparagine depletion, such as cancer, in patients who have had relapses after prior L-asparaginase or pegaspargase treatment.