Patent No. EP2453962 (titled "Negatively Biased Sealed Nebulizers Systems And Methods") was filed by Nektar Therapeutics on Jul 19, 2010. The application was issued on Mar 14, 2018.
Positive bias pressure within a sealed reservoir to improve the efficiency and consistency of a liquid mist ejected from the vibrating aperture plate of a nebulizer. The pressure is reduced by sealing the liquid reservoir of the nebulizer and discharging an amount of liquid drug from the reservoir.

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