Patent No. EP2529622 (titled "Inhibitors Of Bruton'S Tyrosine Kinase") was filed by Pharmacyclics on Dec 28, 2006. The application was issued on Jan 17, 2018.
Compounds that inhibit Bruton's tyrosine kinase (Btk) for treating diseases like autoimmune disorders, inflammatory conditions, and cancers. The compounds are irreversible inhibitors that form a covalent bond with a cysteine residue in Btk. They have structures with a 1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl) prop-2-en-1-one core.

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