Patent No. EP2694043 (titled "Combinations Comprising Brexpiprazole Or A Salt Thereof And A Second Drug For Use In The Treatment Of A Cns Disorder") was filed by Otsuka Pharmaceutical on Apr 4, 2012. The application was issued on Nov 1, 2017.
Combining the drug 7-[4-(4-benzo[b]thiophen-4-yl-piperazin-1-yl)butoxy]-1H-quinolin-2-one (Compound (I)) with selective serotonin reuptake inhibitors (SSRIs) or serotonin and norepinephrine reuptake inhibitors (SNRIs) to improve antidepressant efficacy and reduce side effects compared to monotherapy with either drug. The combination targets multiple neurotransmitter systems for more comprehensive antidepressant action. It also enables lower dosing frequency due to sustained release properties of Compound (I).

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