Method And Apparatus For Combination Of Localization Microscopy And Structured Illumination Microscopy
Patent No. EP2801854 (titled "Method And Apparatus For Combination Of Localization Microscopy And Structured Illumination Microscopy") was filed by Ruprecht Karls Universitt Heidelberg on May 10, 2013. The application was issued on Jul 19, 2017.
Patent Summary
A fluorescence microscope that combines structured illumination microscopy (SIM) and localization microscopy (LM) to achieve super-resolution imaging of fluorescently labeled samples. The microscope features a switching mechanism that enables alternating between SIM and LM modes, allowing for high-intensity illumination for LM and low-intensity illumination for SIM. The SIM mode uses structured illumination patterns to enhance resolution, while the LM mode uses high-intensity illumination to achieve precise localization of individual fluorophores. The microscope's design enables serial acquisition of images using both SIM and LM, allowing for the combination of high-resolution structural information with precise localization data.
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Date
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EP2801854
- Application Number
- EP13002490A
- Filing Date
- May 10, 2013
- Status
- Granted And Under Opposition
- Jun 16, 2017
- Publication Date
- Jul 19, 2017
- External Links
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