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Propane-I-Sulfonic Acid {3- [5- (4- Chloro-Phenyl) -1H-Pyrrolo [2, 3-B} Pyridine-3-Carbonyl] -2, 4-Difluoro-Phenyl} -Amide Compositions And Uses Thereof

Patent No. EP2955180 (titled "Propane-I-Sulfonic Acid {3- [5- (4- Chloro-Phenyl) -1H-Pyrrolo [2, 3-B} Pyridine-3-Carbonyl] -2, 4-Difluoro-Phenyl} -Amide Compositions And Uses Thereof") was filed by F Hoffmann LA Roche on Mar 31, 2010. The application was issued on Jan 10, 2018.

Patent Summary

Improving the solubility and bioavailability of the compound propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide (Compound I) by forming solid dispersions and molecular complexes with polymers. This involves microprecipitating Compound I with a polymer like hydroxypropyl methylcellulose acetate succinate (HPMC-AS) using methods like spray drying, lyophilization, solvent-controlled precipitation, pH-controlled precipitation, hot melt extrusion, and supercritical fluid technology. The resulting compositions have improved water solubility and bioavailability compared to the cryst

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GENERICS UKOct 5, 2018ELKINGTON AND FIFE

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EP2955180

F HOFFMANN LA ROCHE
Application Number
EP15171526A
Filing Date
Mar 31, 2010
Status
Revoked
Feb 6, 2024
Publication Date
Jan 10, 2018
External Links
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