Patent No. EP3050882 (titled "Piperidin-4-Yl Azetidine Derivatives As Jak1 Inhibitors") was filed by Incyte on Mar 9, 2011. The application was issued on Jan 31, 2018.
Selective JAK1 inhibitors for treating diseases associated with JAK1 overactivity, such as autoimmune disorders, allograft rejection, and cancers. The compounds are derived from a specific chemical structure and have selectivity for inhibiting JAK1 over other JAKs like JAK2, JAK3, and TYK2. This provides therapeutic advantages by avoiding unnecessary immunosuppression and anemia/bleeding side effects associated with less selective JAK inhibitors. The compounds can be administered alone or in combination therapies for treating diseases involving JAK1 overactivity.

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