Formulation Of Boronic Acid Compounds

Patent No. EP3078667 (titled "Formulation Of Boronic Acid Compounds") was filed by The United States OF America on Jan 25, 2002. The application was issued on Nov 21, 2018.

Patent Summary

Stable, pharmaceutically acceptable compositions of boronic acid compounds are prepared by lyophilizing an aqueous mixture of the boronic acid and a dihydroxy compound, such as mannitol. The resulting lyophilized composition readily releases the boronic acid compound upon dissolution in aqueous media, forming a boronate ester that equilibrates with the free boronic acid. The compositions exhibit enhanced stability and longer shelf life compared to free boronic acid compounds, and can be reconstituted to provide a bioactive boronic acid compound.

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Patent Oppositions (11)

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Dossier Documents

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EP3078667

THE UNITED STATES OF AMERICA
Application Number
EP16157001A
Filing Date
Jan 25, 2002
Status
Granted And Under Opposition
Oct 19, 2018
Publication Date
Nov 21, 2018