IP Verse

Antibodies With Modified Affinity To Fcrn That Promote Antigen Clearance

Patent No. EP3181581 (titled "Antibodies With Modified Affinity To Fcrn That Promote Antigen Clearance") was filed by Chugai Seiyaku Kabushiki Kaisha on Mar 30, 2011. The application was issued on Sep 25, 2024.

Patent Summary

Antigen-binding molecules, such as antibodies, that facilitate antigen uptake into cells by leveraging human FcRn binding activity in acidic pH environments. The molecules exhibit enhanced FcRn binding in neutral pH conditions and reduced antigen binding affinity in acidic pH conditions, enabling efficient antigen internalization and recycling. This property enables the molecules to repeatedly bind and eliminate multiple antigens, reducing plasma antigen concentrations and enhancing pharmacokinetics. The molecules can be engineered through targeted amino acid substitutions in the FcRn binding domain or antigen binding domain to optimize their properties.

Patent Family

Patent family tree
Statuses, jurisdictions and citation links are shared on request.

Patent Oppositions

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentative
STRAWMANJun 25, 2025CABINET PLASSERAUD

Dossier Documents

The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.

  • Date

    Description

EP3181581

CHUGAI SEIYAKU KABUSHIKI KAISHA
Application Number
EP17154576A
Filing Date
Mar 30, 2011
Status
Granted And Under Opposition
Aug 22, 2024
Publication Date
Sep 25, 2024
External Links
Slate, Register , Google Patents