Patent No. EP3238773 (titled "Drug Coated Inflatable Balloon Having A Thermal Dependent Release Layer") was filed by Medtronic Vascular on Apr 28, 2017. The application was issued on Nov 22, 2023.
A medical device comprises an inflatable balloon having an interior surface defining an interior space and an exterior surface. A temperature-responsive coating containing a therapeutic agent is disposed on the exterior surface. The coating features a release transition temperature between approximately 30°C and 35°C; it retains at least a portion of the therapeutic agent when below this temperature and releases it when above. The coating may comprise a temperature-responsive hydrogel, such as alkyl acrylamide polymers (e.g., poly(N-isopropylacrylamide)), and therapeutic agents like paclitaxel, zotarolimus, sirolimus, or dexamethasone. Heating may be passive (body temperature) or active via a heating element. The coating may be a single layer or multiple layers. The device is used to deliver agents to vessel walls during angioplasty.

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