Patent No. EP3240885 (titled "Structured Biological Samples For Analysis By Mass Cytometry") was filed by Fluidigm Canada on Dec 31, 2015. The application was issued on Nov 13, 2024.
Mass cytometry system for analyzing biological samples through targeted desorption and ionization of discrete locations. The system employs a carrier with discrete sites that release biological samples upon energy pulse application, enabling precise control over sample locations for mass spectrometry analysis. The carrier's surface features multiple desorption sites that can be activated by specific energy pulses, allowing for controlled desorption of individual cells or cell clusters. The desorbed material is then ionized and analyzed using mass spectrometry. This approach significantly improves sample introduction efficiency compared to traditional methods, enabling the analysis of complex biological samples with high spatial resolution.

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