IP Verse

Method Of Treating Cancer Using Immune Checkpoint Inhibitor

Patent No. EP3322731 (titled "Method Of Treating Cancer Using Immune Checkpoint Inhibitor") was filed by Bristol Myers Squibb on Jul 14, 2016. The application was issued on Jan 13, 2021.

Patent Summary

This invention provides an antibody or antigen-binding portion that specifically binds to Programmed Death-1 (PD-1) or Programmed Death-Ligand 1 (PD-L1) to inhibit PD-1 or PD-L1 activity. The agent is used to treat subjects with squamous cell carcinoma head and neck cancer (SCCHN) derived from human papilloma virus (HPV), regardless of HPV positivity or negativity. Methods include measuring HPV levels to identify suitable subjects and administering a therapeutically effective amount of the antibody, such as nivolumab or pembrolizumab, as monotherapy or in combination with other anti-cancer agents (e.g., anti-CTLA-4, anti-VEGF, or chemotherapy). The disclosure also includes kits comprising the antibody and instructions for determining HPV status. The treatment applies to primary, metastatic, or recurrent solid tumors in human patients.

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Patent Family

Patent Oppositions (9)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentative
APPLEYARD LEES FLECK BARBARAOct 13, 2021APPLEYARD LEES
GREINEROct 13, 2021GREINER
MAIWALD PATENTANWALTSOct 13, 2021MAIWALD PATENT- UND RECHTSANWALTSGESELLSCHAFT MBH
BIONTECHOct 12, 2021THOMANN
MERCK SHARP & DOHMEOct 12, 2021MERCK SHARP & DOHME
PATENT BOUTIQUEOct 12, 2021PATENT BOUTIQUE
KRAUS & WEISERTOct 7, 2021KRAUS & LEDERER PARTGMBB
REGENERON PHARMACEUTICALSOct 7, 2021J A KEMP
ISA PHARMACEUTICALS B.VOct 6, 2021VAN DEN HAZEL

Dossier Documents

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EP3322731

BRISTOL MYERS SQUIBB
Application Number
EP16744626A
Filing Date
Jul 14, 2016
Status
Revoked
Feb 6, 2026
Publication Date
Jan 13, 2021
External Links
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