Patent No. EP3351620 (titled "Metabolically Optimized Cell Culture") was filed by Regeneron Pharmaceuticals on Oct 10, 2014. The application was issued on Sep 2, 2020.
Production of proteins and/or polypeptides in cell culture that metabolically shift to lactate consumption. The production is achieved by culturing cells comprising a nucleic acid sequence encoding a protein of interest in a first cell culture and determining a metabolic shift to lactate consumption has occurred in said first cell culture.

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