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Differential Output Of Analog Memories Storing Nanopore Measurement Samples

Patent No. EP3353544 (titled "Differential Output Of Analog Memories Storing Nanopore Measurement Samples") was filed by F Hoffmann LA Roche on Sep 20, 2016. The application was issued on Feb 21, 2024.

Patent Summary

A nanopore measurement circuit comprises a nanopore electrode, a first analog memory, a second analog memory, and a switch network configured to selectively connect the electrode to at least one of the analog memories. Output circuitry is selectively connected to both analog memories to read out stored voltage values. Comparison circuitry receives these outputted voltage values to calculate a difference value. The circuit is designed for nanopore-based sequencing, where nanopore resistance varies based on internal molecular states (e.g., open-channel or tag-occupied), resulting in different voltage decay rates. This architecture aims to reduce exported data bandwidth and avoid the area-intensive noise, offset, and drift issues associated with operational amplifiers in large-scale sensor arrays.

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CompanyOpposition DateRepresentative
OXFORD NANOPORENov 21, 2024J A KEMP

Dossier Documents

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EP3353544

F HOFFMANN LA ROCHE
Application Number
EP16775113A
Filing Date
Sep 20, 2016
Status
Granted And Under Opposition
Jan 19, 2024
Publication Date
Feb 21, 2024
External Links
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