Patent No. EP3565551 (titled "Methods Of Treating Bacterial Infections") was filed by Melinta Therapeutics on Jan 8, 2018. The application was issued on Mar 20, 2024.
Combination therapy of vaborbactam and meropenem for treating urinary tract infections (UTIs) and acute pyelonephritis (AP) in patients with severe comorbidities. The combination provides enhanced efficacy against carbapenem-resistant Enterobacteriaceae (CRE) pathogens, particularly in patients with high-risk profiles such as those with SIRS, severe renal impairment, or a Charlson comorbidity score ≥3. The combination achieves superior clinical outcomes compared to standard meropenem-vaborbactam or piperacillin-tazobactam combinations.

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