"Chimeric Molecules And Uses Thereof"
Patent No. EP3601367 (titled ""Chimeric Molecules And Uses Thereof"") was filed by The University OF Queensland on Mar 29, 2018. The application was issued on Oct 9, 2024.
Patent Summary
Chimeric polypeptides based on viral fusion proteins that stabilize the pre-fusion conformation for improved vaccine efficacy. The chimeric polypeptides contain a viral fusion protein ectodomain fused to a heterologous structure-stabilizing moiety. The moiety forms an anti-parallel two-helix bundle that oligomerizes into a six-helix bundle. This prevents the fusion protein from rearranging to the post-fusion conformation. The chimeric polypeptide can be self-assembled into complexes. The stabilized pre-fusion conformation allows better vaccine antigenicity against enveloped viruses compared to natural post-fusion forms.
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Date
Description
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EP3601367
- Application Number
- EP18775234A
- Filing Date
- Mar 29, 2018
- Status
- Granted And Under Opposition
- Sep 6, 2024
- Publication Date
- Oct 9, 2024
- External Links
- Slate, Register , Google Patents