Chromatography
Patent No. EP3655420 (titled "Chromatography") was filed by UCB Biopharma on Jul 16, 2018. The application was issued on Nov 12, 2025.
Patent Summary
This industrial-scale process purifies a product biomolecule from a feedstock containing impurities using a single chromatography matrix. The method involves loading the feedstock onto the matrix to bind the biomolecule, then eluting it to produce an eluate. This eluate is separated into a first fraction of purified biomolecule and a second fraction (comprising leading and/or trailing fractions) containing both the biomolecule and impurities. The second fraction is held in containers and subsequently re-loaded onto the same chromatography matrix, either simultaneously or sequentially with additional feedstock. Finally, the biomolecule is eluted again to obtain a purified product. This single-matrix recycling approach reduces resin costs and equipment complexity compared to multi-column continuous chromatography.
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Date
Description
EP3655420
- Application Number
- EP18746627A
- Filing Date
- Jul 16, 2018
- Status
- Granted And Under Opposition
- Oct 10, 2025
- Publication Date
- Nov 12, 2025
- External Links
- Slate, Register , Google Patents