Patent No. EP3666797 (titled "Antigen Binding Proteins To Proprotein Convertase Subtilisin Kexin Type 9 (Pcsk9)") was filed by Amgen on Aug 22, 2008. The application was issued on May 17, 2023.
Monoclonal antibodies that bind to the catalytic domain of PCSK9, a cholesterol-lowering protein, and prevent or reduce the binding of PCSK9 to LDLR. These antibodies can be used to treat or prevent hypercholesterolemia and atherosclerotic diseases by inhibiting PCSK9's function. The antibodies bind to specific regions of PCSK9's heavy and light chain variable domains.
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