New Combination Of Active Agents For The Treatment Of Progressive Fibrosing Interstitial Lung Diseases (Pf-Ild)
Patent No. EP3700529 (titled "New Combination Of Active Agents For The Treatment Of Progressive Fibrosing Interstitial Lung Diseases (Pf-Ild)") was filed by Boehringer Ingelheim on Oct 12, 2018. The application was issued on Jul 9, 2025.
Patent Summary
This invention provides a combination treatment for Progressive Fibrosing Interstitial Lung Diseases (PF-ILD), specifically Idiopathic Pulmonary Fibrosis (IPF) and Systemic Sclerosis ILD (SSc-ILD). The combination comprises a therapeutically effective amount of Nintedanib (or its monoethanesulfonate salt) and a PDE4B-inhibitor of formula I, preferably formula III. Formula I features a 6-membered aromatic Ring A with a chlorine substituent (R=Cl) and a chiral sulfur atom (S*). This combination demonstrates an overadditive synergistic inhibitory effect on fibroblast proliferation and inhibits the fibroblast-to-myofibroblast transition, providing complementary therapeutic efficacy to Nintedanib alone. The treatment aims to slow disease progression with acceptable gastrointestinal tolerability. Nintedanib is preferably administered to achieve a human free fraction between 1 nMol/L and 300 nMol/L.
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Dossier Documents
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Date
Description
EP3700529
- Application Number
- EP18785961A
- Filing Date
- Oct 12, 2018
- Status
- Granted And Under Opposition
- Jun 6, 2025
- Publication Date
- Jul 9, 2025
- External Links
- Slate, Register , Google Patents