Compositions And Methods For Increasing Or Enhancing Transduction Of Gene Therapy Vectors And For Removing Or Reducing Immunoglobulins

Patent No. EP3768304 (titled "Compositions And Methods For Increasing Or Enhancing Transduction Of Gene Therapy Vectors And For Removing Or Reducing Immunoglobulins") was filed by Genethon on Jul 17, 2019. The application was issued on Oct 12, 2022.

Patent Summary

Improving gene therapy by degrading antibodies that bind to viral vectors and inhibit their effectiveness. The method involves administering enzymes that degrade immunoglobulins or inhibit antibody function to patients undergoing gene therapy. This reduces pre-existing antibodies against vectors and allows re-dosing with the same vector. The enzymes can be proteases that cleave peptide bonds or glycosidases that cleave carbohydrate residues.

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Patent Oppositions (6)

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Dossier Documents

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EP3768304

GENETHON
Application Number
EP19740384A
Filing Date
Jul 17, 2019
Status
Granted And Under Opposition
Sep 9, 2022
Publication Date
Oct 12, 2022