Apixaban Formulations

A novel formulation for oral administration of apixaban that enables controlled release of the anticoagulant in food and beverages. The formulation comprises a treated core comprising a core substrate and apixaban and a carrier on the core substrate, wherein the apixaban and carrier are in a layer formed on a surface of the core substrate. The treated core is formed through a spray-layered dispersion process with apixaban in a solvent below its solubility limit. The formulation is suitable for administration through capsules, sticks, or other delivery systems that can be dispensed or dissolved in food or beverages.