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Adam6 Knockin Mice

Patent No. EP3785536 (titled "Adam6 Knockin Mice") was filed by Trianni on Aug 28, 2019. The application was issued on Sep 17, 2025.

Patent Summary

Transgenic mice engineered to restore male fertility through expression of a functional ADAM6 protein. The mice comprise a genetic modification that reduces expression of endogenous Adam6 genes, achieved by replacing endogenous immunoglobulin heavy chain variable regions with human immunoglobulin sequences. The ADAM6 transgene is embedded in the immunoglobulin heavy chain variable region locus and is functional in male mice, enabling the production of human VH-containing monoclonal antibodies while maintaining fertility.

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REGENERON PHARMACEUTICALSOct 25, 2022GRUND

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EP3785536

TRIANNI
Application Number
EP19194093A
Filing Date
Aug 28, 2019
Status
Patent Maintained As Amended
Aug 15, 2025
Publication Date
Sep 17, 2025
External Links
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