Fenfluramine Compositions And Methods Of Preparing The Same
Patent No. EP3800177 (titled "Fenfluramine Compositions And Methods Of Preparing The Same") was filed by Zogenix on Dec 20, 2016. The application was issued on Jan 29, 2025.
Patent Summary
A method for preparing fenfluramine active pharmaceutical ingredient (API) with reduced levels of impurities, particularly trifluoromethyl regioisomers. The method involves hydrolyzing 2-(3-(trifluoromethyl)phenyl)acetonitrile to produce 2-(3-(trifluoromethyl)phenyl)acetic acid, reacting the acid with acetic anhydride to form 1-(3-(trifluoromethyl)phenyl)propan-2-one, and reductively aminating the ketone with ethylamine to produce fenfluramine. The resulting API has a purity profile of at least 90% fenfluramine, less than 0.2% 2-fenfluramine, less than 0.2% 4-fenfluramine, and less than 1% fenfluramine alcohol.
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Date
Description
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EP3800177
- Application Number
- EP20210227A
- Filing Date
- Dec 20, 2016
- Status
- Granted And Under Opposition
- Dec 26, 2024
- Publication Date
- Jan 29, 2025
- External Links
- Slate, Register , Google Patents