Method And Compositions For Cellular Immunotherapy
Patent No. EP3824905 (titled "Method And Compositions For Cellular Immunotherapy") was filed by Fred Hutchinson Cancer Center on Aug 20, 2013. The application was issued on Jan 8, 2025.
Patent Summary
Methods and compositions for enhancing the efficacy of chimeric antigen receptor (CAR) T cell therapy for cancer treatment. The methods involve customizing the length of the spacer region between the CAR's ligand binding domain and transmembrane domain to optimize T cell activation and proliferation in response to specific tumor antigens. The spacer length is determined based on the epitope's proximity to the cell membrane, with longer spacers used for membrane-proximal epitopes and shorter spacers used for membrane-distal epitopes. The customized CAR T cells exhibit enhanced therapeutic activity in preclinical models compared to conventional CAR T cells.
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Date
Description
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EP3824905
- Application Number
- EP20201497A
- Filing Date
- Aug 20, 2013
- Status
- Granted And Under Opposition
- Dec 6, 2024
- Publication Date
- Jan 8, 2025
- External Links
- Slate, Register , Google Patents