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Method Of Treating Cancer Using Immune Checkpoint Inhibitor; Antibody That Binds To Programmed Death-1 Receptor (Pd-1) Or Programmed Death Ligand 1 (Pd-L1)

Patent No. EP3858859 (titled "Method Of Treating Cancer Using Immune Checkpoint Inhibitor; Antibody That Binds To Programmed Death-1 Receptor (Pd-1) Or Programmed Death Ligand 1 (Pd-L1)") was filed by Bristol Myers Squibb on Jul 14, 2016. The application was issued on Oct 29, 2025.

Patent Summary

Nivolumab is used as a monotherapy for treating subjects with recurrent or metastatic human papillomavirus (HPV) positive squamous cell carcinoma of the head and neck (SCCHN). The method comprises administering a therapeutically effective amount of nivolumab, an anti-PD-1 antibody, to a subject in need thereof. HPV positivity may be identified by measuring HPV levels in a subject sample, including identifying nucleotide sequences or proteins such as p16, Ki-67, Cyclin D1, p53, ProEx C, E6, or E7, or via p16 immunohistochemistry showing strong and diffuse nuclear and cytoplasmic staining in over 50% to 70% of tumor cells. The therapy aims to increase progression-free survival and overall response rates compared to standard-of-care treatments.

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Patent Oppositions (10)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentative
STORZJul 29, 2026-
BRAND MURRAY FULLERJul 28, 2026BRAND MURRAY FULLER
DEVA HOLDINGJul 28, 2026-
MAIWALD PATENTANWALTSJul 28, 2026MAIWALD PATENT- UND RECHTSANWALTSGESELLSCHAFT MBH
PAJAROJul 28, 2026BIRD & BIRD
GREINERJul 27, 2026GREINER
POHLMANJul 17, 2026PAGE
MANZERJul 13, 2026TER MEER STEINMEISTER & PARTNER GBR
MANZERJul 13, 2026TER MEER UND PARTNER
WUESTHOFF & WUESTHOFFMar 12, 2026WICHMANN

Dossier Documents

The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.

  • Date

    Description

EP3858859

BRISTOL MYERS SQUIBB
Application Number
EP20214749A
Filing Date
Jul 14, 2016
Status
Granted And Under Opposition
Sep 26, 2025
Publication Date
Oct 29, 2025
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