Carbon-Source Regulated Protein Production In A Recombinant Host Cell
Patent No. EP3874047 (titled "Carbon-Source Regulated Protein Production In A Recombinant Host Cell") was filed by Lonza on Jan 10, 2020. The application was issued on Dec 25, 2024.
Patent Summary
A method for producing a recombinant protein in a host cell that reduces the risk of cell morphology changes during production. The method involves genetically modifying the host cell to reduce expression of the FLO8 protein, which is involved in cell morphology regulation, and then expressing the recombinant protein under the control of a regulatable promoter that is repressed by a non-methanol carbon source. The modified host cell is cultured under conditions that induce protein production while maintaining cell morphology stability.
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Date
Description
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EP3874047
- Application Number
- EP20700131A
- Filing Date
- Jan 10, 2020
- Status
- Patent Maintained As Amended
- Nov 22, 2024
- Publication Date
- Dec 25, 2024
- External Links
- Slate, Register , Google Patents