Urolithin A And A Composition Containing Same For External Use In Inflammations Of Various Etiologies
Patent No. EP3886808 (titled "Urolithin A And A Composition Containing Same For External Use In Inflammations Of Various Etiologies") was filed by Microbiota MED SP Z OO on Nov 29, 2019. The application was issued on Jan 15, 2025.
Patent Summary
This pharmaceutical composition for topical external administration comprises one or more typical auxiliary substances and an active ingredient consisting of urolithin A or urolithin A 3,8-diacetate, preferably synthetic urolithin A. The composition is intended for the treatment, inhibition, and prevention of inflammatory diseases of the skin and/or mucous membranes. By utilizing topical administration, the composition bypasses gastrointestinal dehydroxylation and phase II glucuronidation, ensuring active concentrations reach the site of inflammation. Urolithin A inhibits calprotectin secretion and the NF-κB signaling pathway (p65 subunit translocation), offering an alternative to steroids and calcineurin inhibitors without associated tachyphylaxis or severe side effects. The composition may be liquid or semi-solid and may further include steroids, calcineurin inhibitors, or antibacterial, antifungal, or antiviral agents.
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Date
Description
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EP3886808
- Application Number
- EP19836819A
- Filing Date
- Nov 29, 2019
- Status
- Granted And Under Opposition
- Dec 13, 2024
- Publication Date
- Jan 15, 2025
- External Links
- Slate, Register , Google Patents