Patent No. EP3897646 (titled "Pharmaceutical Composition For The Treatment Of Pulmonary Arterial Hypertension") was filed by Actelion Pharmaceuticals on Dec 20, 2019. The application was issued on May 22, 2024.
A combination therapy for pulmonary arterial hypertension (PAH) that targets patients with mild to moderate disease. The treatment involves administering macitentan at a high dose of 60-90 mg/day, with a preferred regimen of 75 mg/day. This combination therapy combines macitentan with phosphodiesterase type 5 inhibitors (PDE5is) and prostacyclin analogues, offering improved disease control and potential long-term benefits over traditional treatments.

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