Patent No. EP4056176 (titled "Methods Of Reducing The Risk Of Cardiovascular Events In A Subject") was filed by Amarin Pharmaceuticals Ireland on Apr 22, 2019. The application was issued on Apr 24, 2024.
Compositions for reducing cardiovascular risk in patients with established cardiovascular disease or high cardiovascular risk, particularly those on statin therapy. The compositions contain ethyl EPA, a naturally occurring omega-3 fatty acid with cardiovascular protective effects, and are formulated to achieve a therapeutic dose of ethyl EPA while maintaining a controlled daily dose of ethyl EPA. The compositions can be administered orally, either as a single dose or in a sustained-release formulation, and have demonstrated cardiovascular benefits in patients on statin therapy, including reduced risk of cardiovascular events, including myocardial infarction, stroke, and cardiac arrest.

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