Patent No. EP4096717 (titled "Treatment Of Cancer") was filed by Innate Pharma on Jan 28, 2021. The application was issued on Dec 11, 2024.
Antibody-drug conjugates (ADCs) targeting Nectin-4 for treating cancers with low or heterogeneous Nectin-4 expression, including bladder, breast, lung, and pancreatic cancers. The ADCs comprise a Nectin-4-binding antibody conjugated to a camptothecin analogue, such as exatecan, through a cleavable linker. The ADCs can be used in patients with Nectin-4-expressing cancers who have received prior chemotherapy or have resistance to HER2-targeted therapies. The ADCs exhibit improved efficacy and reduced toxicity compared to existing Nectin-4-targeted ADCs, enabling treatment of patients with low or moderate Nectin-4 expression levels.

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| Company | Opposition Date | Representative |
|---|---|---|
| STRAWMAN | Sep 11, 2025 | DORRIES |
| ARROWHOUSE | Sep 10, 2025 | VOSSIUS & PARTNER PATENTANWALTE RECHTSANWALTE MBB |
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