Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof

Patent No. EP4108671 (titled "Modified Nucleosides, Nucleotides, And Nucleic Acids, And Uses Thereof") was filed by Moderna on Oct 3, 2011. The application was issued on Nov 20, 2024.

Patent Summary

Modified nucleic acids that reduce innate immune response and enhance protein expression by incorporating nucleoside modifications, such as 1-methyl-pseudouridine, into mRNA sequences. These modifications disrupt binding of major groove interacting partners, enabling efficient translation of therapeutic proteins in cells while minimizing immune activation. The modified nucleic acids can be used to treat various diseases by delivering functional proteins directly to target cells, eliminating the need for viral vectors or gene integration.

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Patent Family

Patent Oppositions (6)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentative
BIONTECHAug 20, 2025WILK
MAIWALDAug 20, 2025MAIWALD
PATENT BOUTIQUEAug 20, 2025PATENT BOUTIQUE
PFIZERAug 20, 2025PFIZER
WITHERS & ROGERSAug 20, 2025TOMBLING
SANOFIFeb 28, 2025CARPMAELS & RANSFORD

Dossier Documents

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EP4108671

MODERNA
Application Number
EP22173763A
Filing Date
Oct 3, 2011
Status
Granted And Under Opposition
Oct 18, 2024
Publication Date
Nov 20, 2024