Patent No. EP4175620 (titled "Compositions, Methods And Systems For Aerosol Drug Delivery") was filed by Astrazeneca Pharmaceuticals LP on Jul 8, 2022. The application was issued on Apr 10, 2024.
Targeted drug delivery system for respiratory therapy that delivers active agents to the respiratory tract through a metered dose inhaler. The system comprises a propellant of pharmaceutical grade HFO-1234ze(E) and a combination of glycopyrrolate, formoterol, and budesonide particles. The propellant is formulated with perforated microstructured phospholipid particles, which provide mechanical stability and prevent aggregation. The combination delivers precise, controlled doses of these active agents through the inhaler's actuator mechanism, maintaining consistent delivery performance even in simulated storage conditions.

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