Patent No. EP4181943 (titled "Treatment Of Post-Operative Surgical Pain") was filed by Ipsen Biopharm on Jul 16, 2021. The application was issued on Dec 17, 2025.
Botulinum toxin A given 10–20 days before surgery to stop post-op pain and anxiety by blocking nerve signals before incision. The toxin travels from the injection site to the spinal cord, cutting off pain signals before they reach the brain. This approach avoids opioid addiction and prevents chronic pain that often follows poor acute management.

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