Patent No. EP4188389 (titled "Methods Of Treating Chronic Kidney Disease With Dapagliflozin") was filed by Astrazeneca on Apr 1, 2021. The application was issued on Sep 17, 2025.
Treatment of chronic kidney disease (CKD) in patients with and without type 2 diabetes using sodium glucose co-transporter type 2 (SGLT2) inhibitors, such as dapagliflozin, to reduce CKD progression, cardiovascular events, and mortality. The treatment also prevents or delays the onset of type 2 diabetes in prediabetic patients.

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.
| Company | Opposition Date | Representative |
|---|---|---|
| SANDOZ | May 12, 2026 | TER MEER STEINMEISTER & PARTNER |
| GENERICS UK | Sep 17, 2025 | ELKINGTON AND FIFE |
The dossier documents provide a comprehensive record of the patent's prosecution history - including filings, correspondence, and decisions made by patent offices - and are crucial for understanding the patent's legal journey and any challenges it may have faced during examination.
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