IP Verse

Novel Synthesis Of Salcaprozic Acid By Amide Formation

Patent No. EP4284774 (titled "Novel Synthesis Of Salcaprozic Acid By Amide Formation") was filed by Novo Nordisk on Jan 28, 2022. The application was issued on Mar 12, 2025.

Patent Summary

A method for producing a compound of formula (I), specifically 8-[(2-hydroxybenzoyl)amino]octanoic acid or its derivatives (e.g., SNAC), comprises reacting a compound of formula (II) with a compound of formula (III). R1 and R2 are selected from hydrogen, C1-C6-alkyl, phenyl, benzyl, Mg2+, Ca2+, Li+, Na+, and K+. X is selected from O-alkyl, O-phenyl, O-benzyl, and N-hydroxysuccinimide ester. The process involves reacting 8-amino caprylic acid (or derivative) with a salicylic acid derivative, such as methyl salicylate. The method may be performed as a batch or continuous flow process using a reactor coil, potentially employing KOMe. This sustainable, cost-efficient process is designed for large-scale production of intermediates used to enhance the oral bioavailability of protein- and peptide-based pharmaceuticals.

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Patent Oppositions (2)

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CompanyOpposition DateRepresentative
ZHANGNov 28, 2025KAYA
JAMES POOLEOct 28, 2025CARPMAELS & RANSFORD

Dossier Documents

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  • Date

    Description

EP4284774

NOVO NORDISK
Application Number
EP22703590A
Filing Date
Jan 28, 2022
Status
Granted And Under Opposition
Feb 7, 2025
Publication Date
Mar 12, 2025
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