IP Verse

New Use Of A Combination Of An Angiotensin Receptor Blocker (Arb) With A Neutral Endopeptidase Inhibitor (Nepi)

Patent No. EP4321157 (titled "New Use Of A Combination Of An Angiotensin Receptor Blocker (Arb) With A Neutral Endopeptidase Inhibitor (Nepi)") was filed by Novartis on Aug 26, 2014. The application was issued on Oct 23, 2024.

Patent Summary

A medicament for preventing or delaying cardiovascular mortality and hospitalizations in patients with chronic systolic heart failure, comprising a therapeutically effective amount of an Angiotensin Receptor Neprilysin inhibitor (ARNi) or a combination of an Angiotensin Receptor Blocker (ARB) with a Neutral Endopeptidase inhibitor (NEPi) pro-drug in a 1:1 molar ratio. The medicament significantly reduces the risk of cardiovascular death and hospitalization for heart failure compared to standard ACE inhibitor therapy in patients with reduced ejection fraction.

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Patent Family

Patent Oppositions (18)

Patent oppositions filed by competitors challenge the validity of a granted patent. These oppositions are typically based on claims of prior art, lack of novelty, or non-obviousness. They are a key part of the process for determining a patent's strength and enforceability.

CompanyOpposition DateRepresentative
ALFRED E TIEFENBACHERJul 23, 2025HAMM & WITTKOPP
BETAPHARM ARZNEIMITTELJul 23, 2025HAMM & WITTKOPP
HAMM & WITTKOPPJul 23, 2025HAMM & WITTKOPP
KRKAJul 23, 2025HOFFMANN EITLE
LANYON OPPOSITIONSJul 23, 2025PINSENT MASONS
POLPHARMAJul 23, 2025HAMM & WITTKOPP
WUESTHOFF & WUESTHOFFJul 23, 2025SONNENHAUSER
HAMM & WITTKOPPJul 23, 2025HAMM & WITTKOPP
BULLE DRJul 22, 2025KUTZENBERGER WOLFF & PARTNER
TEVA PHARMACEUTICALSJul 22, 2025D YOUNG
DEVA HOLDINGJul 22, 2025-
CAMULONJul 21, 2025REDDIE & GROSE
ELPEN PHARMACEUTICALJul 21, 2025HASELTINE LAKE KEMPNER
EGISJul 18, 2025STOLMAR & PARTNER
DR SCHONJul 16, 2025DR SCHON
SYNTHONJul 14, 2025HOFFMANN EITLE
GENERICS UKJul 1, 2025ELKINGTON AND FIFE
ZENTIVA KSJun 25, 2025GREINER

Dossier Documents

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EP4321157

NOVARTIS
Application Number
EP23202190A
Filing Date
Aug 26, 2014
Status
Granted And Under Opposition
Sep 20, 2024
Publication Date
Oct 23, 2024
External Links
Slate, Register , Google Patents