Sustained Release Of Oleic Acid From Contact Lenses
Patent No. EP4413405 (titled "Sustained Release Of Oleic Acid From Contact Lenses") was filed by Coopervision on Sep 25, 2023. The application was issued on Jun 18, 2025.
Patent Summary
An unworn silicone hydrogel contact lens is provided, sealed in a package and comprising a polymeric lens body loaded with at least one 2-oleoyl phospholipid. The lens is designed to release oleic acid (as free acid or salts) to enhance wearer comfort and reduce lens awareness. The 2-oleoyl phospholipid is susceptible to digestion by human tear sPLA2 enzymes (specifically sPLA2-IIA), which hydrolyze the acyl group at the sn2 position. Specifically, when exposed to an artificial tear serum (ATF) containing 50 ppm human sPLA2 for four hours at 37°C, the lens releases at least two times more oleic acid than when exposed to ATF without human sPLA2. The phospholipid is typically loaded into the lens body during an extraction step using an organic solvent.
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Date
Description
EP4413405
- Application Number
- EP23785834A
- Filing Date
- Sep 25, 2023
- Status
- Granted And Under Opposition
- May 16, 2025
- Publication Date
- Jun 18, 2025
- External Links
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