Compositions And Methods For Analyte Detection
Patent No. EP4491741 (titled "Compositions And Methods For Analyte Detection") was filed by President And Fellows OF Harvard College on Dec 21, 2012. The application was issued on Oct 15, 2025.
Patent Summary
A method for identifying multiple analytes in cell or tissue mounted on a solid support involves contacting the sample with a composition of detection reagents. Each reagent subpopulation targets a distinct analyte and comprises at least one probe conjugated to at least one predetermined subsequence. After removing unbound reagents, the predetermined subsequences are sequenced in a temporally-sequential manner to generate a temporal order of optical signal signatures. This temporal order is unique to each reagent subpopulation and is used to identify the corresponding analytes. The method enables high-plex multiplexing by utilizing a time-series of optical labels, where the number of detectable analytes increases multiplicatively with the number of detection steps and available optical labels.
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EP4491741
- Application Number
- EP24195205A
- Filing Date
- Dec 21, 2012
- Status
- Granted And Under Opposition
- Sep 12, 2025
- Publication Date
- Oct 15, 2025
- External Links
- Slate, Register , Google Patents