Semiconductor Source Based Near Infrared Measurement Device With Improved Signal-To-Noise Ratio

Patent No. US10874304 (titled "Semiconductor Source Based Near Infrared Measurement Device With Improved Signal-To-Noise Ratio") was filed by Omni Medsci Inc on Oct 31, 2019.

What is this patent about?

’304 is related to the field of lasers and light sources for healthcare, medical, dental, or bio-technology applications. More specifically, it concerns systems and methods for using near-infrared or short-wave infrared light sources for early detection of dental caries. Traditional methods for caries detection, such as visual examination and x-ray imaging, can be subjective and may not detect early-stage lesions effectively. Current imaging methods based on light transport changes within the tooth, like fiber-optic trans-illumination and quantitative light-induced fluorescence (QLF), have limitations in quantification, contrast, and discrimination between caries and stains.

The underlying idea behind ’304 is to improve the signal-to-noise ratio in optical measurements of blood constituents by increasing the light intensity from semiconductor sources in the near-infrared spectrum. This increased intensity helps overcome challenges posed by interfering spectral features from other blood constituents and the skin. The system also captures light when the light source is off and subtracts this from the signal when the light source is on, further reducing noise.

The claims of ’304 focus on a measurement system comprising a light source with multiple semiconductor sources, a measurement device, a receiver, a smartphone or tablet, and a cloud. The light source is configured to generate an output optical beam with one or more optical wavelengths and to increase signal-to-noise ratio by increasing light intensity. The receiver is configured to receive and process reflected or transmitted light from a sample, generate an output signal representing a non-invasive measurement on blood, synchronize to the light source, and improve the signal-to-noise ratio by differencing signals captured when the light source is on and off .

In practice, the system works by modulating the light source and synchronizing the receiver to this modulation, using a lock-in technique to detect the modulation frequency and reject noise. The receiver also captures light while the light source is off and subtracts this from the signal when the light source is on, further reducing noise. The smartphone or tablet processes, stores, and displays the output signal and transmits it to the cloud, which processes and stores the data. This allows for remote monitoring and analysis of the data by healthcare providers.

This approach differs from prior solutions by using a combination of increased light intensity and signal differencing to improve signal-to-noise ratio. Prior art methods often rely on weaker light sources or do not effectively account for background noise and interfering signals. By using a smartphone and cloud connectivity, the system also enables remote monitoring and data analysis, which is not typically found in traditional caries detection methods. The use of multiple semiconductor sources allows for a broader spectrum of light to be used, which can improve the accuracy of the measurements.

How does this patent fit in bigger picture?

Technical landscape at the time

In the early 2010s when ’304 was filed, non-invasive physiological measurements using near-infrared spectroscopy were gaining traction, at a time when signal processing techniques were commonly relied upon to improve the signal-to-noise ratio in such measurements. Wearable devices were also becoming more prevalent, but hardware and software constraints made it non-trivial to integrate complex signal processing and data analysis capabilities directly into the device itself.

Novelty and Inventive Step

The examiner approved the application because the prior art, whether considered individually or in combination, did not disclose the specific claimed features. These features include generating an output signal representing a non-invasive measurement on blood, synchronizing to the light source, capturing light while the semiconductor sources are off and converting it into a first signal.

Claims

This patent contains 27 claims, with claims 1, 11, and 19 being independent. The independent claims are directed to measurement systems and wearable devices that use a light source with multiple semiconductor sources to perform non-invasive measurements, particularly on blood, and involve processing and transmitting data to a smartphone/tablet and a cloud. The dependent claims generally elaborate on specific components, configurations, and functionalities of the measurement systems and wearable devices described in the independent claims.

Key Claim Terms New

Definitions of key terms used in the patent claims.

Term (Source)Support for SpecificationInterpretation
Analysis output beam
(Claim 1, Claim 11)
“The apparatus is configured to: receive a portion of the output optical beam, and deliver an analysis output beam to a sample. The receiver is configured to: receive and process at least a portion of the analysis output beam reflected or transmitted from the sample, generate an output signal, and synchronize to the light source.”A portion of the output optical beam that is delivered to a sample for analysis.
Differencing the first signal and the second signal
(Claim 1, Claim 11, Claim 19)
“The receiver is configured to capture light while the LEDs are off and convert the captured light into a first signal, and to capture light while at least one of the LEDs is on and to convert the captured light into a second signal, the captured light including at least a portion of the optical beam reflected from the tissue. The measurement device is configured to improve a signal-to-noise ratio of the optical beam reflected from the tissue by differencing the first signal and the second signal and by differencing the two receiver outputs.”A method to improve the signal-to-noise ratio by subtracting the signal captured when the light source is off from the signal captured when the light source is on.
Input optical beam
(Claim 19)
“The measurement device is configured to: generate, by modulating at least one of the semiconductor sources having an initial light intensity, an input optical beam having one or more optical wavelengths, and receive and to deliver a portion of the input optical beam to tissue, wherein the tissue reflects at least a portion of the input optical beam delivered to the tissue.”An optical beam generated by modulating at least one of the semiconductor sources having an initial light intensity.
Non-invasive measurement
(Claim 1, Claim 11, Claim 19)
“One approach to non-invasive monitoring of blood constituents or blood analytes is to use near-infrared spectroscopy, such as absorption spectroscopy or near-infrared diffuse reflection or transmission spectroscopy. Some attempts have been made to use broadband light sources, such as tungsten lamps, to perform the spectroscopy. However, several challenges have arisen in these efforts. First, many other constituents in the blood also have signatures in the near-infrared, so spectroscopy and pattern matching, often called spectral fingerprinting, is required to distinguish the glucose with sufficient confidence.”A measurement on blood contained within the sample, performed without penetrating the skin.
Output optical beam
(Claim 1, Claim 11)
“The light source comprises a plurality of semiconductor sources that are configured to generate an output optical beam with one or more optical wavelengths, the light source is configured to increase signal-to-noise ratio by increasing a light intensity from at least one of the plurality of semiconductor sources.”A beam of light generated by a plurality of semiconductor sources, having one or more optical wavelengths, used for analysis.

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US10874304

OMNI MEDSCI INC
Application Number
US16669794
Filing Date
Oct 31, 2019
Status
Granted
Expiry Date
Dec 17, 2033
External Links
Slate, USPTO, Google Patents