Nicotine Salt Formulations For Aerosol Devices And Methods Thereof

Patent No. US10952468 (titled "Nicotine Salt Formulations For Aerosol Devices And Methods Thereof") was filed by Envenio Inc on Oct 28, 2015.

What is this patent about?

’468 is related to the field of electronic cigarettes and, more specifically, to nicotine salt formulations used within them. Traditional e-liquids often use freebase nicotine, which can be harsh at higher concentrations. The industry is constantly seeking formulations that provide a smoother, more satisfying nicotine delivery experience, mimicking the rapid uptake and satisfaction associated with traditional cigarettes.

The underlying idea behind ’468 is to use a nicotine salt formed with benzoic acid in a specific formulation for e-cigarettes. By using benzoic acid to create the nicotine salt, the inventors aimed to achieve a more efficient and satisfying nicotine delivery. The key insight is that this particular salt, when vaporized, provides a smoother inhalation and a faster nicotine uptake compared to freebase nicotine, more closely resembling the experience of smoking a traditional cigarette.

The claims of ’468 focus on an electronic cigarette cartridge containing a nicotine salt liquid formulation. This formulation comprises a nicotine salt formed from nicotine and benzoic acid, dissolved in a liquid carrier of glycerol and propylene glycol. The claims specify that the nicotine salt should provide between 3% and 15% nicotine by weight in the aerosol, and that the molar ratio of benzoic acid to nicotine is approximately 1:1.

In practice, the invention involves creating a liquid mixture of nicotine benzoate, glycerol, and propylene glycol within an e-cigarette cartridge. When the e-cigarette's heating element is activated, this liquid is vaporized into an aerosol. The user then inhales this aerosol, receiving a dose of nicotine. The specific ratio of benzoic acid to nicotine ensures the formation of the desired salt, while the glycerol and propylene glycol act as carriers for the nicotine and contribute to the aerosol's properties.

The differentiation from prior approaches lies in the specific use of benzoic acid as the acid in the nicotine salt, combined with the defined concentration range and carrier composition. While nicotine salts were known, the inventors found that nicotine benzoate in this particular formulation provides a superior experience compared to other nicotine salts or freebase nicotine, offering a smoother inhalation and a more rapid nicotine uptake, thus better mimicking the satisfaction derived from traditional cigarettes.

How does this patent fit in bigger picture?

Technical landscape at the time

In the early 2010s when ’468 was filed, electronic cigarettes were at a time when X was typically implemented using Y. Specifically, the formulation of liquids for producing aerosols in electronic cigarettes was an area of active development, with engineers exploring different carrier liquids and additives to optimize nicotine delivery and user experience. At this time, the use of nicotine salts was not yet widespread, and the focus was on freebase nicotine formulations.

Novelty and Inventive Step

The examiner approved the application because the prior art neither taught nor suggested an electronic cigarette, or a method of providing nicotine to a user, wherein a nicotine salt liquid formulation contains a nicotine salt comprised of nicotine and benzoic acid in a 1:1 molar ratio, and in a liquid carrier which includes glycerol and propylene glycol, wherein the nicotine salt is present in an amount that forms from about 3% (w/w) to about 15% (w/w) nicotine in the inhalable aerosol which is generated when the nicotine salt liquid formulation is heated in the electronic cigarette.

Claims

This patent contains 20 claims, of which claims 1, 8, 14, and 15 are independent. The independent claims are directed to an electronic cigarette and methods of using a nicotine salt liquid formulation. The dependent claims generally add further limitations or specific details to the composition of the liquid formulation or the electronic cigarette device.

Key Claim Terms New

Definitions of key terms used in the patent claims.

Term (Source)Support for SpecificationInterpretation
Inhalable aerosol
(Claim 1, Claim 8, Claim 14, Claim 15)
“Provided herein is a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.”An aerosol generated by heating the nicotine salt liquid formulation in an electronic cigarette, suitable for inhalation by a user.
Liquid carrier
(Claim 1, Claim 8, Claim 14, Claim 15)
“Provided herein is a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.”A liquid medium, comprising glycerol and propylene glycol, in which the nicotine salt is dissolved or suspended to form the nicotine salt liquid formulation.
Molar ratio of benzoic acid to nicotine
(Claim 1, Claim 8, Claim 14, Claim 15)
“Provided herein is a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.”The ratio of the amount of benzoic acid to the amount of nicotine in the nicotine salt liquid formulation, which is about 1:1.
Nicotine salt
(Claim 1, Claim 8, Claim 14, Claim 15)
“Provided herein is a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.”A salt formed from nicotine and benzoic acid, present in a liquid formulation within an electronic cigarette cartridge, which upon heating, generates an inhalable aerosol.
Nicotine salt liquid formulation
(Claim 1, Claim 8, Claim 14, Claim 15)
“Provided herein is a method of delivering nicotine to a user comprising operating an electronic cigarette to a user wherein the electronic cigarette comprises a nicotine salt formulation comprising a nicotine salt in a biologically acceptable liquid carrier wherein an acid used to form said nicotine salt is characterized by vapor pressure >20 mmHg at 200° C., and inhaling an aerosol generated from the nicotine salt formulation heated by the electronic cigarette.”A formulation comprising a nicotine salt in a liquid carrier, designed to generate an inhalable aerosol upon heating in an electronic cigarette.

Litigation Cases New

US Latest litigation cases involving this patent.

Case NumberFiling DateTitle
2:25-cv-02853Aug 8, 2025Juul Labs Incorporated V. Njoy Llc

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US10952468

ENVENIO INC
Application Number
US14925961
Filing Date
Oct 28, 2015
Status
Granted
Expiry Date
May 6, 2034
External Links
Slate, USPTO, Google Patents