Cyanotech Corporation vs The Board of Trustees of the University of Illinois et al.

Final Written Decision

Decision - Institution of Inter Partes Review and Consolidation with Case IPR2013-00404

Order - re Conference Call (10/11/2013)

Patent Owner Preliminary Response

Exhibit 2001 - Complaint Civil No 12-352

Exhibit 2002 - PTAB Decision 9-13-2013

Mandatory Notices

Power of Attorney

Related Matters

Notice of Accepting Corrected Petition

Corrected Petition for Inter Partes Review of U.S. Patent No. 5,527,533

Notice of Filing Date Accorded to Petition

Petition for Inter Partes Review of U.S. Patent No. 5,527,533

Power of Attorney

Fee Authorization

Power of Attorney

U.S. Patent No. 5,527,533

Grangaud, René, “Astaxanthin Research, New Vitamin A Factor”, 69 pp. (Éditions Desoer, Liège, 1951), English translation

Grangaud, René, “Recherches sur l’Astaxanthine, Nouveau Facteur, Vitaminique A”, 69 pp. (Éditions Desoer, Liège, 1951), in French

Massonet, Reneé, “Research into the Biochemistry of Astaxanthin”, 146 pp. (F.Fontana, Algiers, 1960), English translation

Massonet, Reneé, “Recherches sur la Biochemie de l’Astaxanthine,”, 146 pp. (F.Fontana, Algiers, 1960, in French

Office Actions and Responses (including Declarations) in App. No. 08/330,194

Bibliographic citations and abstracts of the Grangaud and Massonet References, including exemplary searches in Chemical Abstracts print media (1947 to 1965) and online databases

Massonet, R. et al. “The Study of Astaxanthin Transformation into Vitamin A in the Albino Rat: in vitro Experiments”, Ann. Nutrit. Alimentation, Vol. 19 pp. pages C655-C658 (1965)), English translation

Massonet, R. et al. “Étude de la transformation de l'astaxanthine en vitamine A chez le Rat albinos: Expériences ‘in vitro’”, Ann. Nutrit. Alimentation, Vol. 19 pp. pages C655-C658 (1965)), in French

Grangaud, R. et al. “Transformation of Astaxanthin to Vitamin A in the Albino Rat: Neoformation in vivo and in vitro”, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, Vol. 252, pp. 1854-1856 (1961b), English translation

Grangaud, R. et al. "Transformation de l'astaxanthine en vitamine A chez le Rat albinos: néoformation in vivo et in vitro”, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, Vol. 252, pp. 1854-1856 (1961b), in French

Massonet, R. et al. “Transformation of astaxanthin to vitamin A by ocular tissue of the rat in vitro”, Comptes Rendus Hebdomadaires des seances de la Societe de biologie et de ses filiales, Vol. 155, pp. 747-750 (1961a), English translation

Massonet, R. et al. “Transformation in vitro de l'astaxanthine en vitamine A par le tissu oculaire du Rat”, Comptes Rendus Hebdomadaires des seances de la Societe de biologie et de ses filiales, Vol. 155, pp. 747-750 (1961a) , in French

Grangaud, R. et al. “Antixerophthalmic effect of the esters of astaxanthin”, Comptes Rendus Hebdomadaires des seances de la Societe de biologie et de ses filiales, Vol. 148, pp. 1392-1394 (1954), English translation

Grangaud, R. et al. “Activité antixérophtalmique des esters de l'astaxanthine”, Comptes Rendus Hebdomadaires des seances de la Societe de biologie et de ses filiales, Vol. 148, pp. 1392-1394 (1954), in French

Grangaud, R. et al. “Antixerophthalmic Activity of the Carotenoid Pigment of the Aristeomorpha foliacea (Penæidæ)”, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, Vol. 230, pp. 1319-1321 (March 27, 1950), English translation

Grangaud, R. et al. “Activité antixérophtalmique du pigment caroténoïde d'Aristeomorpha foliacea (Penæidæ)”, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, Vol. 230, pp. 1319-1321 (March 27, 1950) , in French

Grangaud, R. et al. “The Action of Shrimp Oil (Penaeus foliaceus) on the Vitamin A Deficient White Rat”, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, Vol. 227, pp. 568-570 (1948), English translation

Grangaud, R. et al. “Action de l'huile de Crevette (Penaeus foliaceus) sur le Rat blanc carence en vitamine A”, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, Vol. 227, pp. 568-570 (1948), in French

Kurashige, M. et al., "Inhibition of Oxidative Injury of Biological Membranes by Astaxanthin", Physiol. Chem. Phys. and Med. NMR, 22, pp. 27-38 (1990)

U.S. Patent No. 5,310,764 (“Treatment of age related macular degeneration with beta-carotene”), to Baranowitz, et al., issued 10 May 1994

Herisset, Armand, “Antioxidant properties of carotenoids and their derivatives”. Comptes Rendus Hebdomadaires des Séances de l’Académie des Sciences, v.253, pp. 47-49 (July – December) 1946, English translation

Herisset, Armand, “Propriétés antioxygènes des carotènoïdes et de leurs derives”. Comptes Rendus Hebdomadaires des Séances de l’Académie des Sciences, v.253, pp. 47-49 (July – December) 1946, in French

Dowling, J.E. and Wald, G., “Vitamin A deficiency and night blindness”. (US) PNAS 44:648, (1958)

Dowling, J.E. and Wald, G., “The Biological Function of Vitamin A,” (US) PNAS 46(5), 587–608 (1960)

Dowling, J.E. and Gibbons, I.R., “The effect of vitamin A deficiency on the fine structure of the retina”, in The Structure of the Eye, Smelser C.K., editor. New York, Academic Press, Inc., p. 85-99 (1961)

Hayes, K.C., “Retinal degeneration in monkeys induced by deficiencies of vitamin E or A,” Invest. Ophthalmol. Vis. Sci., vol. 13 no. 7, 499-510 (July, 1974)

Berson, E., “Nutrition And Retinal Degenerations: Vitamin A, Taurine, Ornithine, and Phytanic Acid,” Retina: Vol.2, Issue 4, pp 236-255 (Fall 1982)

Reading, V.M., Weale, R.A., Aberration, C., Malinow, M.R., “The Effect of Deficiency of Vitamins E And A on the Retina”, Nutrition Reviews, Volume 38, Issue 11, pages 386–389 (Nov. 1980)

Carter-Dawson, L. et al.: Structural and Biochemical Changes in Vitamin A-Deficient Rat Retinas. Invest. Ophthalmol. Vis. Sci. 18: 437-446, (1979)

Schiedt et al., “Recent progress on carotenoid metabolism in animals”, Pure & Appl Chem, Vol. 63, No. 1 pp 89-100 (1991)

Retinal Cross-section and Xanthophyll

Declaration of Florian J. Schweigert

Declaration of Scott Bennett

Zigler, J.S. and Hess H.H., “Cataracts in the Royal College of Surgeons Rat: Evidence for Initiation by Lipid Peroxidation Products”, Exp. Eye. Res., 41:67-76 (1985)

Goto, H. et al. “Chemotactic activity of the peroxidized retinal membrane lipids in experimental autoimmune uveitis”, Current Eye Res., Vo. 10, No. 11, 1009-1014 (1991)

U.S. Nutraceuticals LLC dba Valensa International, and The Board of Trustees of the University of Illinois vs. Cyanotech Corporation, and Nutrex Hawaii, Inc. Civ. 5:12-cv-366-oc-10PRL (M.D.Fla), filed 29 June 2012

Cyanotech Corporation vs. U.S. Nutraceuticals LLC dba Valensa International, and The Board of Trustees of the University of Illinois, Civ. No. 1:12-cv-00352-JMS-RLP (D.Haw.), filed 20 June 2012

Supplementary Declaration of Florian J. Schweigert

Definitions from Stedman’s Medical Dictionary, 28th Edition (2006)

Declaration of Barbara Schneider-Kempf (Staatsbibliothek zu Berlin), in German

Declaration of Barbara Schneider-Kempf (State Library of Berlin), English translation

Declaration of Stéphane Alcandre (Bibliothèque Nationale de France), in French

Declaration of Stéphane Alcandre (National Library of France), in English