The detailed information for PTAB case with proceeding number IPR2013-00535 filed by BioMarin Pharmaceutical Inc. against Duke University et al. on Aug 28, 2013. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
IPR2013-00535
Filing Date
Aug 28, 2013
Petitioner
BioMarin Pharmaceutical Inc.
Respondent
Duke University et al.
Status
Final Written Decision
Respondent Application Number
09902461
Respondent Tech Center
1600
Respondent Patent Number
7056712
Institution Decision Date
Feb 24, 2014
Termination Date
Feb 23, 2015

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Patent Owner Duke University's Notice of Appeal

Mar 19, 2018PAPERPATENT OWNER

Supplemental Final Written Decision - Proceedings on Remand - 35 USC 144 and 318(a)

Jan 17, 2018PAPERBOARD

Duke's Notice of Appeal

Sep 11, 2015PAPERPATENT OWNER

Decision - Request for Rehearing

Jul 14, 2015PAPERBOARD

Duke University's Reply in Support of its Request for Rehearing

May 4, 2015PAPERPATENT OWNER

Biomarin Opposition to Duke University Request for Rehearing

Apr 29, 2015PAPERPETITIONER

Duke University's Request for Rehearing Under 37 C.F.R. 42.71(d)

Mar 25, 2015PAPERPATENT OWNER

Final Written Decision

Feb 23, 2015PAPERBOARD

Record of Proceedings

Nov 19, 2014PAPERBOARD

Duke's Exhibit List No. 6 Under 37 C.F.R. 42.63(e)

Sep 26, 2014PAPERPATENT OWNER

BioMarin's Submission of Demonstrative Exhibits

Sep 26, 2014PAPERPETITIONER

BioMarin's Tenth List of Exhibits

Sep 26, 2014PAPERPETITIONER

Oral Hearing Demonstrative Exhibt

Sep 26, 2014EXHIBITPETITIONER

Duke's Demonstratives Under 37 C.F.R. 42.70(b)

Sep 26, 2014EXHIBITPATENT OWNER

BioMarin's Reply to Genzyme's Opposition to Motion to Exclude Evidence (6439-0102L)

Sep 18, 2014PAPERPETITIONER

Duke's Reply on its Motion to Exclude Evidence Under 37 C.F.R. 42.64

Sep 18, 2014PAPERPATENT OWNER

Order - Trial Hearing

Sep 17, 2014PAPERBOARD

Order - Conduct of the Proceeding

Sep 16, 2014PAPERBOARD

Duke's First Supplemental Mandatory Notices Pursuant to 37 C.F.R. 42.8(a)(3)

Sep 11, 2014PAPERPATENT OWNER

Duke's Opposition to BioMarin's Motion to Exclude Evidence

Sep 11, 2014PAPERPATENT OWNER

BioMarin's Opposition to Duke's Motion to Exclude Evidence (6439-0102L)

Sep 11, 2014PAPERPETITIONER

Liberty Mutual Final Order

Sep 11, 2014EXHIBITPETITIONER

Advisory Committee Notes

Sep 11, 2014EXHIBITPETITIONER

BioMarin's Request For Oral Hearing

Aug 28, 2014PAPERPETITIONER

Duke's Request for Oral Argument Under 37 C.F.R. 42.70

Aug 28, 2014PAPERPATENT OWNER

Duke's Motion to Exclude Evidence Under 37 C.F.R. 42.64

Aug 28, 2014PAPERPATENT OWNER

BioMarin's Motion to Exclude Evidence

Aug 28, 2014PAPERPETITIONER

BioMarin's Eighth List of Exhibits

Aug 28, 2014PAPERPETITIONER

Exhibit 1167

Aug 28, 2014EXHIBITPETITIONER

Exhibit 1168

Aug 28, 2014EXHIBITPETITIONER

Duke's Submission of the Certificate of Service of Objections to Evidence Served by BioMarin on August 14, 2014 Under 37 C.F.R. 42.64

Aug 21, 2014PAPERPATENT OWNER

BioMarin's Petitioner Reply to Duke's Patent Owner Response

Aug 14, 2014PAPERPETITIONER

BioMarin's Seventh List of Exhibits

Aug 14, 2014PAPERPETITIONER

Exhibit 1144

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1154

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1155

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1157

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1158

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1159

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1160

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1161

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1162

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1163

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1164

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1165

Aug 14, 2014EXHIBITPETITIONER

Exhibit 1166

Aug 14, 2014EXHIBITPETITIONER

Duke's Exhibit List No. 5 Under 37 C.F.R. 42.63(e)

Aug 13, 2014PAPERPATENT OWNER

Transcript of the June 25, 2014 deposition of Philip Green

Aug 13, 2014EXHIBITPATENT OWNER

Transcript of the July 1, 2014 deposition of Richard D. Cummings, Ph.D.

Aug 13, 2014EXHIBITPATENT OWNER

Transcript of the July 17, 2014 deposition of Melissa Wasserstein, M.D.

Aug 13, 2014EXHIBITPATENT OWNER

BioMarin's Notice of Deposition of Melissa Wasserstein

Jul 7, 2014PAPERPETITIONER

Order - Revision to Scheduling Order regarding Due Date 7

Jun 30, 2014PAPERBOARD

BioMarin's Notice of Deposition of Richard Cumming

Jun 27, 2014PAPERPETITIONER

Notice of Deposition of Philip Green

Jun 13, 2014PAPERPETITIONER

Order - Petitioner's Motion to Compel Additional Discovery

Jun 10, 2014PAPERBOARD

BioMarin's Sixth List of Exhibits

May 30, 2014PAPERPETITIONER

Deposition Transcript of Matthew Croughan

May 30, 2014EXHIBITPETITIONER

Deposition Transcript of Gregory Pastores

May 30, 2014EXHIBITPETITIONER

DUKE EXHIBIT LIST NO. 4 UNDER 37 C.F.R. 42.63(e)

May 22, 2014PAPERPATENT OWNER

DUKE PATENT OWNER RESPONSE UNDER 37 C.F.R 42.120

May 22, 2014PAPERPATENT OWNER

Transcript for the deposition of Matthew S. Croughan, Ph.D. on April 16, 2014, in IPR2013-00534.

May 22, 2014EXHIBITPATENT OWNER

Declaration of Matthew S. Croughan, Ph.D. in IPR2013-00534.

May 22, 2014EXHIBITPATENT OWNER

U. S. Patent No. 7,629,309 to LeBowitz et al., issued December 8, 2009

May 22, 2014EXHIBITPATENT OWNER

U.S. Patent No. 6,537,785 to Canfield, issued March 25, 2003.

May 22, 2014EXHIBITPATENT OWNER

de Barsy et al. (1973)

May 22, 2014EXHIBITPATENT OWNER

Pastores and Hughes (2009)

May 22, 2014EXHIBITPATENT OWNER

Declaration of Melissa Wasserstein, M.D.

May 22, 2014EXHIBITPATENT OWNER

Declaration of Richard D. Cummings, Ph.D.

May 22, 2014EXHIBITPATENT OWNER

Declaration of Philip Green

May 22, 2014EXHIBITPATENT OWNER

Williams and Murray (1980)

May 22, 2014EXHIBITPATENT OWNER

Bodamer et al. (1997).

May 22, 2014EXHIBITPATENT OWNER

Slonim et al. (1983)

May 22, 2014EXHIBITPATENT OWNER

Umpleby et al. (1987)

May 22, 2014EXHIBITPATENT OWNER

Margolis and Hill (1986)

May 22, 2014EXHIBITPATENT OWNER

Mistry et al. (1996)

May 22, 2014EXHIBITPATENT OWNER

Isaacs et al. (1986)

May 22, 2014EXHIBITPATENT OWNER

Berggard and Bearn (1965)

May 22, 2014EXHIBITPATENT OWNER

Crocker and Farber (1958)

May 22, 2014EXHIBITPATENT OWNER

Funk et al. (1992)

May 22, 2014EXHIBITPATENT OWNER

FDA Approves First Treatment for Pompe Disease (2006)

May 22, 2014EXHIBITPATENT OWNER

Transcript for the deposition of Gregory M. Pastores on May 9, 2014, in IPR2013-00534 (Pages 1-150)

May 22, 2014EXHIBITPATENT OWNER

Transcript for the deposition of Gregory M. Pastores on May 9, 2014, in IPR2013-00534 (Pages 151-266)

May 22, 2014EXHIBITPATENT OWNER

FDA Approves New Treatment for Late-Onset Pompe Disease (2010)

May 22, 2014EXHIBITPATENT OWNER

Hug and Schubert (1967)

May 22, 2014EXHIBITPATENT OWNER

Hermans et al. (1993)

May 22, 2014EXHIBITPATENT OWNER

Mutsaers et al. (1987)

May 22, 2014EXHIBITPATENT OWNER

Van der Ploeg et al. (1991)

May 22, 2014EXHIBITPATENT OWNER

Ogawara et al. (1999)

May 22, 2014EXHIBITPATENT OWNER

Friedman et al. (1999)

May 22, 2014EXHIBITPATENT OWNER

Morell et al. (1968)

May 22, 2014EXHIBITPATENT OWNER

Hubbard et al. (1979)

May 22, 2014EXHIBITPATENT OWNER

Ashwell and Harford (1982)

May 22, 2014EXHIBITPATENT OWNER

Santell et al. (1999)

May 22, 2014EXHIBITPATENT OWNER

Wisselaar et al. (1993)

May 22, 2014EXHIBITPATENT OWNER

Reuser et al. (1984)

May 22, 2014EXHIBITPATENT OWNER

McVie-Wylie et al. (2003)

May 22, 2014EXHIBITPATENT OWNER

van der Ploeg et al. (1988)

May 22, 2014EXHIBITPATENT OWNER

Reuser et al. (2002)

May 22, 2014EXHIBITPATENT OWNER

For Houma girl, Katrina's disruption a matter of life or death

May 22, 2014EXHIBITPATENT OWNER

150 attend first Innovation Council symposium, Chen honored for myozyme work

May 22, 2014EXHIBITPATENT OWNER

Fighting Pompe Disease

May 22, 2014EXHIBITPATENT OWNER

A Tale of Two Sisters- Treatment for Rare Genetic Disease Offers New Hope, Pompe Disease Affects About 10,000 People Worldwide

May 22, 2014EXHIBITPATENT OWNER

Distinguished Winners 1994 to 2007, James D. Watson Helix Awards Honor Biotechs Top Performers

May 22, 2014EXHIBITPATENT OWNER

Prix Galien-Committees, Galien Award abroad

May 22, 2014EXHIBITPATENT OWNER

Wonder drug helps Azaria fight killer muscle disease

May 22, 2014EXHIBITPATENT OWNER

Sarnat, et al. (1982)

May 22, 2014EXHIBITPATENT OWNER

Selak et al. (2000)

May 22, 2014EXHIBITPATENT OWNER

Verity (1991)

May 22, 2014EXHIBITPATENT OWNER

90M Payday at Duke-Triangle Business Journal (2011)

May 22, 2014EXHIBITPATENT OWNER

China Synthetic Rubber to Collect Huge Royalty From Orphan Drug, China Economic News Service (2006)

May 22, 2014EXHIBITPATENT OWNER

Genzyme and Sanofi public report extracts

May 22, 2014EXHIBITPATENT OWNER

Licensing Executive Society of Biopharmaceutical Deal Rates and Terms, June 2008

May 22, 2014EXHIBITPATENT OWNER

Edwards

May 22, 2014EXHIBITPATENT OWNER

Canfield provisional application Serial No. 60/153,831, filed on September 14, 1999.

May 22, 2014EXHIBITPATENT OWNER

Excerpts from Parr-Royalty Rates for Pharmacuticals and Biotechnology (2010)

May 22, 2014EXHIBITPATENT OWNER

Myozyme becomes Lumizyme after biologics scale-up (2009)

May 22, 2014EXHIBITPATENT OWNER

Myozyme (alglucosidase alfa) Highlights of Prescribing Information

May 22, 2014EXHIBITPATENT OWNER

Lumizyme Highlights of Prescribing Information

May 22, 2014EXHIBITPATENT OWNER

Technology Assignment Agreement (between Duke and Synpac)

May 22, 2014EXHIBITPATENT OWNER

Duke drug on verge of FDA nod

May 22, 2014EXHIBITPATENT OWNER

Tong et al. (1989)

May 22, 2014EXHIBITPATENT OWNER

Excerpts from Genzyme Form 10-K, Annual Report for the fiscal year ended December 31, 2010, related to the number of patients.

May 22, 2014EXHIBITPATENT OWNER

Excerpts from Genzyme Form 10-K, Annual Report for the fiscal year ended December 31, 2010, related to royalty obligations in connection with Myozyme/Lumizyme.

May 22, 2014EXHIBITPATENT OWNER

DiMauro et al. (2000)

May 22, 2014EXHIBITPATENT OWNER

Fernandes et al. (1988)

May 22, 2014EXHIBITPATENT OWNER

Myozyme Formulatory Information

May 22, 2014EXHIBITPATENT OWNER

prosecution history of USPN 7056712

May 22, 2014EXHIBITPATENT OWNER

Prosecution history of USPN 7351410

May 22, 2014EXHIBITPATENT OWNER

Cummings (1992)

May 22, 2014EXHIBITPATENT OWNER

Stahl (1990)

May 22, 2014EXHIBITPATENT OWNER

Kornfeld (1976)

May 22, 2014EXHIBITPATENT OWNER

Second Notice of Joint Stipulation to Modify Due Dates 1, 2 and 3

May 13, 2014PAPERPATENT OWNER

Duke's Submission of the Certificate of Service of Objections to Second Supplemental Evidence Served by BioMarin on April 21, 2014 Under 37 C.F.R. 42.64

Apr 28, 2014PAPERPATENT OWNER

BioMarin's Second Notice of Submission of Supplemental Evidence in Response to Duke's Objections to Exhibits

Apr 21, 2014PAPERPETITIONER

BioMarin's Fifth List of Exhibits

Apr 21, 2014PAPERPETITIONER

Order - Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of Irena Royzman

Apr 18, 2014PAPERBOARD

Order - Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of David N. Slarskey

Apr 18, 2014PAPERBOARD

Order - Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of Steven A. Zalesin

Apr 18, 2014PAPERBOARD

Duke's Opposition to BioMarin's Motion to Compel Additional Discovery

Apr 11, 2014PAPERPATENT OWNER

Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of Irena Royzman Pursuant to 37 C.F.R. 42.10

Apr 9, 2014PAPERPATENT OWNER

Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of David N. Slarskey Pursuant to 37 C.F.R. 42.10

Apr 9, 2014PAPERPATENT OWNER

Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of Steven A. Zalesin Pursuant to 37 C.F.R. 42.10

Apr 9, 2014PAPERPATENT OWNER

Duke's Exhibit List No. 3 Under 37 C.F.R. 42.63(e)

Apr 9, 2014PAPERPATENT OWNER

Revised Declaration of Irena in Support of Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of Irena Royzman Pursuant to 37 C.F.R. 42.10

Apr 9, 2014EXHIBITPATENT OWNER

Revised Declaration of David N. Slarskey in Support of Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of David N. Slarskey Pursuant to 37 C.F.R. 42.10

Apr 9, 2014EXHIBITPATENT OWNER

Revised Declaration of Steven A. Zalesin in Support of Patent Owner's Revised Unopposed Motion for Admission Pro Hac Vice of Steven A. Zalesin Pursuant to 37 C.F.R. 42.10

Apr 9, 2014EXHIBITPATENT OWNER

Notice of Joint Stipulation to Modify Due Dates 1 and 2

Apr 7, 2014PAPERPATENT OWNER

Duke's Revised Notice of Deposition of Matthew Croughan, Ph.D. Under 37 C.F.R. 42.53(d)

Apr 7, 2014PAPERPATENT OWNER

Duke's Notice of Deposition of Gregory M. Pastores, M.D. Under 37 C.F.R. 42.53(d)

Apr 7, 2014PAPERPATENT OWNER

Duke's Submission of the Certificate of Service of Objections to Supplemental Evidence Served by BioMarin on March 31, 2014 Under 37 C.F.R. 42.64

Apr 7, 2014PAPERPATENT OWNER

Order Pro Hac Vice Motion

Apr 4, 2014PAPERBOARD

Order Pro Hac Vice Motion

Apr 4, 2014PAPERBOARD

Order Pro Hac Vice Motion

Apr 4, 2014PAPERBOARD

Biomarin's Fourth List of Exhibits

Apr 4, 2014PAPERPETITIONER

BioMarin Motion for Discovery

Apr 4, 2014PAPERPETITIONER

About EurekAlert

Apr 4, 2014EXHIBITPETITIONER

EurekAlert Terms Conditions

Apr 4, 2014EXHIBITPETITIONER

Durham Herald re Duke 1997

Apr 4, 2014EXHIBITPETITIONER

AMDA 9 pages of press releases

Apr 4, 2014EXHIBITPETITIONER

Duke Obtains FDA Designation For Pompe Disease Therapy (IPR2013-00534)

Apr 4, 2014EXHIBITPETITIONER

Affidavit of Christopher Butler (6439-0103L)

Apr 4, 2014EXHIBITPETITIONER

2014-03-10 IPR2013-00535 Objections to Preliminary Evidence

Apr 4, 2014EXHIBITPETITIONER

Request for Production to Duke University

Apr 4, 2014EXHIBITPETITIONER

Duke's Notice of Deposition of Matthew Croughan, Ph.D. Under 37 C.F.R. 42.53(d)

Apr 3, 2014PAPERPATENT OWNER

Order - re Conference Call (03/24/2014)

Apr 2, 2014PAPERBOARD

Order - Petitioner's Motion for Pro Hac Vice Admission of Lynde Herzbach

Apr 1, 2014PAPERBOARD

BioMarin's Notice of Supplemental Evidence in Response to Duke's Objections to Exhibits

Mar 31, 2014PAPERPETITIONER

Biomarin's Third List of Exhibits

Mar 31, 2014PAPERPETITIONER

Motion for Pro Hac Vice Admission of Lynde Herzbach

Mar 26, 2014PAPERPETITIONER

Biomarin's Second List of Exhibits

Mar 26, 2014PAPERPETITIONER

Declaration in Support of Lynde Herzbach

Mar 26, 2014EXHIBITPETITIONER

Expunged

Mar 25, 2014PAPERPATENT OWNER

Expunged

Mar 25, 2014PAPERPATENT OWNER

Expunged

Mar 25, 2014PAPERPATENT OWNER

Patent Owner's Unopposed Motion for Admission Pro Hac Vice of Irena Royzman Pursuant to 37 C.F.R. 42.10

Mar 25, 2014PAPERPATENT OWNER

Patent Owner's Unopposed Motion for Admission Pro Hac Vice of David N. Slarskey Pursuant to 37 C.F.R. 42.10

Mar 25, 2014PAPERPATENT OWNER

Patent Owner's Unopposed Motion for Admission Pro Hac Vice of Steven A. Zalesin Pursuant to 37 C.F.R. 42.10

Mar 25, 2014PAPERPATENT OWNER

Duke's Exhibit List No. 2 Under 37 C.F.R. 42.63(e)

Mar 25, 2014PAPERPATENT OWNER

Declaration of Irena Royzman in Support of Patent Owner's Motion for Admission Pro Hac Vice of Irena Royzman Pursuant to 37 C.F.R. 42.10

Mar 25, 2014EXHIBITPATENT OWNER

Declaration of David N. Slarskey In Support of Patent Owner's Motion for Admission Pro Hac Vice of David N. Slarskey Pursuant to 37 C.F.R. 42.10

Mar 25, 2014EXHIBITPATENT OWNER

Declaration of Steven A. Zalesin in Support of Patent Owner's Motion for Admission Pro Hac Vice of Steven A. Zalesin Pursuant to 37 C.F.R. 42.10

Mar 25, 2014EXHIBITPATENT OWNER

Order - Conduct of the Proceeding - 37 CFR 42.5

Mar 24, 2014PAPERBOARD

Biomarin's List of Proposed Motions

Mar 13, 2014PAPERPETITIONER

Biomarin's Supplemental List of Proposed Motions

Mar 13, 2014PAPERPETITIONER

Duke's List of Currently Anticipated Proposed Motions

Mar 12, 2014PAPERPATENT OWNER

Duke's Submission of Certificate of Service of Objections to Evidence Served by BioMarin on September 10, 2013 Under 37 C.F.R. 42.64

Mar 10, 2014PAPERPATENT OWNER

Decision Institution of Inter Partes Review

Feb 24, 2014PAPERBOARD

Scheduling Order

Feb 24, 2014PAPERBOARD

Order - re Conference Call

Dec 31, 2013PAPERBOARD

Order - Conduct of the Proceeding

Dec 10, 2013PAPERBOARD

Duke's Exhibit List No. 1 Under 37 C.F.R. 42.63(e)

Dec 4, 2013PAPERPATENT OWNER

Duke Preliminary Response Under 37 C.F.R. 42.107

Dec 4, 2013PAPERPATENT OWNER

Appeal Brief (Jan. 8. 2004)

Dec 4, 2013EXHIBITPATENT OWNER

Examiner Answer to Reply Brief (April 7, 2004)

Dec 4, 2013EXHIBITPATENT OWNER

Reply Brief and Request for Oral Hearing (June 14, 2004)

Dec 4, 2013EXHIBITPATENT OWNER

PCT International Application No. WO 2000/34451

Dec 4, 2013EXHIBITPATENT OWNER

Utility Patent Application No. 09/902,461

Dec 4, 2013EXHIBITPATENT OWNER

Office Action (December 3, 2002)

Dec 4, 2013EXHIBITPATENT OWNER

Power of Attorney

Sep 18, 2013PAPERINDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER.

Related Matters

Sep 18, 2013PAPERINDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER.

Notice Accepting Corrected Petition

Sep 11, 2013PAPERBOARD

Response to Notification to Submit Corrected Exhibits

Sep 10, 2013PAPERPETITIONER

US 7,056,712

Sep 10, 2013EXHIBITPETITIONER

Sympac 1999 Press Release

Sep 10, 2013EXHIBITPETITIONER

Sympac Apr 2000 Press Release

Sep 10, 2013EXHIBITPETITIONER

Reuser 1995 WO9705771A2

Sep 10, 2013EXHIBITPETITIONER

Van Bree US 7,351,410

Sep 10, 2013EXHIBITPETITIONER

Kikuchi 1998

Sep 10, 2013EXHIBITPETITIONER

Van Hove 1997

Sep 10, 2013EXHIBITPETITIONER

Bembi 1994

Sep 10, 2013EXHIBITPETITIONER

Barton 1991

Sep 10, 2013EXHIBITPETITIONER

Pompe 1932

Sep 10, 2013EXHIBITPETITIONER

Grabowski 1998

Sep 10, 2013EXHIBITPETITIONER

Brady 1997

Sep 10, 2013EXHIBITPETITIONER

Duke University Press Release Feb. 14, 1998

Sep 10, 2013EXHIBITPETITIONER

van der Ploeg 1988

Sep 10, 2013EXHIBITPETITIONER

Fuller 1995

Sep 10, 2013EXHIBITPETITIONER

Van Hove 1996

Sep 10, 2013EXHIBITPETITIONER

Cori 1954

Sep 10, 2013EXHIBITPETITIONER

Duke University Press Release Sept. 2, 1997

Sep 10, 2013EXHIBITPETITIONER

Hers 1963

Sep 10, 2013EXHIBITPETITIONER

Pastores Declaration

Sep 10, 2013EXHIBITPETITIONER

Croughan Declaration

Sep 10, 2013EXHIBITPETITIONER

Smith 1967

Sep 10, 2013EXHIBITPETITIONER

Swaiman 1968

Sep 10, 2013EXHIBITPETITIONER

Zellweger 1965

Sep 10, 2013EXHIBITPETITIONER

OA of June 14, 2002 - '712 FW

Sep 10, 2013EXHIBITPETITIONER

Amendment filed Sept. 16, 2002 - '712 FW

Sep 10, 2013EXHIBITPETITIONER

Amendment filed March 3, 2003 - '712 FW

Sep 10, 2013EXHIBITPETITIONER

Decision by BPAI June 17, 2005 - '712 FW

Sep 10, 2013EXHIBITPETITIONER

Bijvoet 1998

Sep 10, 2013EXHIBITPETITIONER

Declaration of Dr. Chen - from 7,056,712 FW

Sep 10, 2013EXHIBITPETITIONER

Duke Univ. Press Release May 24, 1999

Sep 10, 2013EXHIBITPETITIONER

U.S. 6,118,045

Sep 10, 2013EXHIBITPETITIONER

Van Bree 10/611,598

Sep 10, 2013EXHIBITPETITIONER

Van Bree 09/454,711

Sep 10, 2013EXHIBITPETITIONER

Van Bree US Provisional No. 60/111,291

Sep 10, 2013EXHIBITPETITIONER

Bijvoet 1996

Sep 10, 2013EXHIBITPETITIONER

Bijvoet 1998a

Sep 10, 2013EXHIBITPETITIONER

Yang 1998

Sep 10, 2013EXHIBITPETITIONER

Reuser 1995

Sep 10, 2013EXHIBITPETITIONER

Hug 1967

Sep 10, 2013EXHIBITPETITIONER

Weinreb Biochim 1968

Sep 10, 2013EXHIBITPETITIONER

Matalon 1972

Sep 10, 2013EXHIBITPETITIONER

Grabowski 1985

Sep 10, 2013EXHIBITPETITIONER

De Duve 1964

Sep 10, 2013EXHIBITPETITIONER

Brady 1973

Sep 10, 2013EXHIBITPETITIONER

Fratatoni 1968

Sep 10, 2013EXHIBITPETITIONER

Kaplan 1977

Sep 10, 2013EXHIBITPETITIONER

Sando 1997

Sep 10, 2013EXHIBITPETITIONER

Baudhuin 1964

Sep 10, 2013EXHIBITPETITIONER

Brady 1974

Sep 10, 2013EXHIBITPETITIONER

Van den Hout 2000

Sep 10, 2013EXHIBITPETITIONER

Grabowski 1995

Sep 10, 2013EXHIBITPETITIONER

DiMarco 1985

Sep 10, 2013EXHIBITPETITIONER

Barton 1990

Sep 10, 2013EXHIBITPETITIONER

Brady 1994

Sep 10, 2013EXHIBITPETITIONER

Wenk 1991

Sep 10, 2013EXHIBITPETITIONER

Pastores 1993

Sep 10, 2013EXHIBITPETITIONER

Mistry 1996

Sep 10, 2013EXHIBITPETITIONER

Beutler 1977

Sep 10, 2013EXHIBITPETITIONER

Richards 1993

Sep 10, 2013EXHIBITPETITIONER

Rosenberg 1999

Sep 10, 2013EXHIBITPETITIONER

US 7,056,712

Sep 10, 2013EXHIBITPETITIONER

Fujita 1991

Sep 10, 2013EXHIBITPETITIONER

van der Ploeg 1990

Sep 10, 2013EXHIBITPETITIONER

Pharming Press Release Nov. 1998

Sep 10, 2013EXHIBITPETITIONER

Banga 1995b

Sep 10, 2013EXHIBITPETITIONER

Hu 2011

Sep 10, 2013EXHIBITPETITIONER

Jayapal 2007

Sep 10, 2013EXHIBITPETITIONER

Wurm 2004

Sep 10, 2013EXHIBITPETITIONER

Spellman 1989

Sep 10, 2013EXHIBITPETITIONER

Einarsson 1985

Sep 10, 2013EXHIBITPETITIONER

Modi 1997

Sep 10, 2013EXHIBITPETITIONER

Marian and Baughman 1997

Sep 10, 2013EXHIBITPETITIONER

Shak 1990

Sep 10, 2013EXHIBITPETITIONER

Ryff 2008

Sep 10, 2013EXHIBITPETITIONER

Ozturk 2006

Sep 10, 2013EXHIBITPETITIONER

Brown 1992

Sep 10, 2013EXHIBITPETITIONER

Bibila 2011

Sep 10, 2013EXHIBITPETITIONER

Hoefsloot 1990-a

Sep 10, 2013EXHIBITPETITIONER

Shak 1995

Sep 10, 2013EXHIBITPETITIONER

Hironaka 1992

Sep 10, 2013EXHIBITPETITIONER

Hotchkiss 1988

Sep 10, 2013EXHIBITPETITIONER

Otter 1992

Sep 10, 2013EXHIBITPETITIONER

Harris 1991

Sep 10, 2013EXHIBITPETITIONER

Bennett 1983

Sep 10, 2013EXHIBITPETITIONER

Deutscher 1986

Sep 10, 2013EXHIBITPETITIONER

Howles 1996

Sep 10, 2013EXHIBITPETITIONER

Lubiniecki 1990

Sep 10, 2013EXHIBITPETITIONER

PDA 2005

Sep 10, 2013EXHIBITPETITIONER

Walsh and Headon 1994

Sep 10, 2013EXHIBITPETITIONER

Banga 1995

Sep 10, 2013EXHIBITPETITIONER

Hoefsloot 1988

Sep 10, 2013EXHIBITPETITIONER

Hoefsloot 1990-b

Sep 10, 2013EXHIBITPETITIONER

Pharming Press Release, November 1996

Sep 10, 2013EXHIBITPETITIONER

Pharming-Genzyme Press Release, February 1999

Sep 10, 2013EXHIBITPETITIONER

Pompe's Bulletin 1997

Sep 10, 2013EXHIBITPETITIONER

DiCioccio 1993

Sep 10, 2013EXHIBITPETITIONER

Cacia 1998

Sep 10, 2013EXHIBITPETITIONER

Yasuda 1993

Sep 10, 2013EXHIBITPETITIONER

Olijve 1996

Sep 10, 2013EXHIBITPETITIONER

US 8,470,552

Sep 10, 2013EXHIBITPETITIONER

Shen 2006

Sep 10, 2013EXHIBITPETITIONER

Hokke 1995

Sep 10, 2013EXHIBITPETITIONER

Reichel and Gmeiner 2010

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de Leeuw 1996

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Lin 1985

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Anson 1992

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Bielicki 1993

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Ioannou 1992

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Kakkis 1994

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Kiss 2011

Sep 10, 2013EXHIBITPETITIONER

Johan van Hove Bio

Sep 10, 2013EXHIBITPETITIONER

Notice of Filing Date Accorded to Petition

Sep 5, 2013PAPERBOARD

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Sep 4, 2013PAPERBOARD

Power of Attorney

Aug 28, 2013PAPERPETITIONER

Petition for Inter Partes Review

Aug 28, 2013PAPERPETITIONER

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