Decision - Denying Institution of Inter Partes Review - 37 CFR 42.108 | Nov 16, 2015 | PAPER | BOARD |
Decision - Denying Sanctions Motion - 37 C.F.R. 42.12 | Sep 25, 2015 | PAPER | BOARD |
Patent Owner Reply Motion for Sanctions | Sep 10, 2015 | PAPER | PATENT OWNER |
Petitioner's Response in Opposition to Patent Owner Motion for Sanctions | Sep 2, 2015 | PAPER | PETITIONER |
Petitioner's Updated Exhibit List | Sep 2, 2015 | PAPER | PETITIONER |
Information for Vermont Prescribers of Prescription Drugs re Revlimid (lenalidomide) capsules | Sep 2, 2015 | EXHIBIT | PETITIONER |
Information for Vermont Prescribers of Prescription Drugs re Pomalyst (pomalidomide) capsules | Sep 2, 2015 | EXHIBIT | PETITIONER |
Orange Book_Approved Drug Products withTherapeutic Equivalence Evaluations_Patent No. 5,635,517 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Second Amended Complaint for Patent Infringement dated March 25, 2011 in Civil Action No. 10-5197 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Complaint for Patent Infringement dated July 20, 2012 in Civil Action No. 12-04571 | Sep 2, 2015 | EXHIBIT | PETITIONER |
To Promote Innovation_The Proper Balance of Competition and Patent Law and Policy | Sep 2, 2015 | EXHIBIT | PETITIONER |
Dwivedi et al., Evergreening_A deceptive device in patent rights, 32 TECHNOLOGY IN SOCIETY, 324-330_2010 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Statement of the Federal Trade Commission, FTC v. Cephalon, Inc., May 28, 2015 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Pay-for-Delay_How Drug Company Pay-Offs Cost Consumers Billions, An FTC Staff Study, January 2010 | Sep 2, 2015 | EXHIBIT | PETITIONER |
The Impact of Exempting the Pharmaceutical Industry from Patent Reviews | Sep 2, 2015 | EXHIBIT | PETITIONER |
Testimony of Professor Owen A. Lamont, June 28, 2006 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Hearing before the Subcommittee on Intellectual Property, Competition, and the Internet of the Committee on the Judiciary House of Representatives, March 10, 2011, Serial No. 112-20 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Hearing before the Subcommittee on Intellectual Property, Competition, and the Internet of the Committee on the Judiciary House of Representatives, March 30, 2011, Serial No. 112-35 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Shepard Report re Neumann v. Vidal, 710 F.2d 856, 228 U.S. App. D.C. 345, 1983 U.S. App. LEXIS 26562, 1983-1 Trade Cas.P65455_1983 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Palmer, E., FDA Grants Celgenes Revlimid New Use, As It Moves Toward 10B in Sales, FIERCEPHARMA, February 19, 2015 | Sep 2, 2015 | EXHIBIT | PETITIONER |
Patent Owner Exhibit List | Aug 19, 2015 | PAPER | PATENT OWNER |
Patent Owner Preliminary Response | Aug 19, 2015 | PAPER | PATENT OWNER |
Patent Owner Motion for Sanctions | Aug 19, 2015 | PAPER | PATENT OWNER |
Dr. V. Pannikar, WHO, - The Return of Thalidomide New Uses and Renewed Concerns | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
FDA website - About the FDA (2014) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Smith, R.L. et al. - Studies on the Relationship Between the Chemical Structure and Embryotoxic Activity of Thalidomide and Related Compounds (1965) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Jonsson, N. Ake - Chemical structure and teratogenic properties (1972) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Powell, R.J. - New roles for thalidomide- A unique anti-inflammatory, but use it only when no alternatives exist (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
517 File History, Notice of References Cited (1997) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
517 File History, Information Disclosure Citation (1997) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
U.S. Patent No. 5,712,291 (1998) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Intentionally Left Blank | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Janeway, Charles, et al. - Immuno Biology 5, The Immune System in Health and Diseases (2001) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Medzhitov, Ruslan - Origin and physiological roles of inflammation (2008) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Bedarida, Gabriella, et al. - Pharmacodynamics and Drug Action H1- and H2-hystamine receptor - mediated vasodilation varies with aging in humans (1995) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Van Nueten, J.M., et al. - Serotonin and Vascular Reactivity (1985) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Swartz, Stephen - The Role of Prostaglandins in Mediating the Effects of Angiotensin Converting Enzyme Inhibitors and Other Antihypertensive Drugs (1987) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Bode-Boger, Stefanie, et al. - L-Arginine Induces Nitric Oxide-Dependent Vasodilation in Patients With Critical Limb Ischemia (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Larkin, S.W. et al. - Prolonged Microvascular Vasodilation Induced by Leukotriene B4 in Human Skin Is Cyclooxygenase Independent (1995) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Bateman, Adrian - Flesh and Bones of Pathology (2009) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Krishnamoorthy, Sriram - Inflammation and disease progression (2006) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Bouwmeester, Tewis et al. - A physical and functional map of the human TNF-aNF-¿B signal transduction pathway (2004) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Page, Theresa et al. - Nonsteroidal Anti-Inflammatory Drugs Increase TNF Production in Rheumatoid Synovial Membrane Cultures and Whole Blood (2010) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Vane, J.R., et al. - Mechanism of Action of Anti-Inflammatory Drugs (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Kurumbail, G., et al. - Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Marie, C., et al. - Regulation by anti-inflammatory cytokines (IL-4, IL-IO, IL-13, TGF) of interleukin-8 production by LPS and/or TNFa-activated human polymorphonuclear cells (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Trepicchio, William, et al. - Recombinant Human IL-11 Attenuates the Inflammatory Response Cytokine Through Down-Regulation of Proinflammatory Release and Nitric Oxide Production (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Patrick, Graham - Drug Development (1995) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Partial Testimony of Dr. Clayton Heathcock, Ph.D., In Re OxyContin Antitrust Litigation (2013) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Testimony of Defendants Expert Witness, Clayton H. Heathcock, Ph.D., Astrazeneca UK Limited et al. v. Watson Laboratories, Inc. et al. (2012) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Hastings, R.C. et al. - Thalidomide analogs with potential activity in erythema nodosum leprosum (1979) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Hastings, Robert - Kellersberger Memorial Lecture 1979 Immunosuppressive Anti-Inflammatory Thalidomide Analogues (1980) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Henderson, Andrew, et al. - C-EBP Activators Are Required for HIV-1 Replication and Proviral Induction in Monocytic Cell Lines (1996) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Herbein, Georges, et al. - The macrophage in HIV-1 infection From activation to deactivation (2010) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Kalebic, Thea, et al. - Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine (1991) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Scifinder - Thalidomide | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Sekut, L., et al. - Anti-inflammatory activity of salmeterol, down-regulation of cytokine production (1995) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Smith, Carla, et al. - Cyclosporin a Blocks Induction of Tumor Necrosis Factor-Alpha in Human B Lymphocytes (1994) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Crutchley, David, et al. - Effects of Prostacyclin Analogs on the Synthesis of Tissue Factor, Tumor Necrosis Factor-a and Interleukin-1ß in Human Monocytic THP-1 Cells1 (1994) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Olivera, D.L., et al. - Effects of pyridinyl imidazole compounds on murine TNF-a production (1993) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Rordorf-Adam, C. et al, - CGP 47969A, A novel inhibitor of the synthesis of inflammatory cytokines (1994) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Helm, F., et al. - Comparative Teratological Investigation of Compounds structurally and pharmacologically Related to Thalidomide (1981) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Barnhill, Raymond, et al. - Thalidomide, Use and possible mode of action in reactional lepromatous leprosy and in various other conditions (1982) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Schmahl, H.J. et al. - Pharmacokinetics of the Teratogenic and Nonteratogenic Thalidomide Analogs EM 12 and Supidimide in the Rat and Marmoset Monkey (1987) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Hassan, Khairy, et al. - Antiinflammatory-Immunosuppressive Thalidomide Analogs (1981) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
King, Barry, et al. - Antiinflammatory-Immunosuppressive Thalidomide Analogs (1985) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Sheskin, J., et al. - Trials with Thalidomide Derivatives in Leprosy Reactions (1968) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Bruns, Robert, et al. - Rules for Identifying Potentially Reactive or Promiscuous Compounds (2012) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Committee on Amines - Aromatic Amines, An Assessment of the Biological and Environmental Effects (1981) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Uetrecht, Jack - Reactivity and Possible Significance of Hydroxylamine and Nitroso Metabolites of Procainamide (1985) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Selleckchem.com - Pomadlidomide Datasheet | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Pomalyst July 2014 Product Information | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Delaware Department of State, Division of Corporations - Coalition for Affordable Drugs | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Delaware Department of State, Division of Corporations - Coalition for Affordable Drugs VI LLC - Entity Details | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
The Wall Street Journal - New Hedge Fund Strategy. Dispute the Patent, Short the Stock (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Business Insider - Hedge Fund Manager Kyle Bass Is Going After Big Pharma And Its BS Patents (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Hayman Capital Management, L.P. June 2015 Form ADV Part 2A Brochure | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
The Wall Street Journal - Innovate or Else, Kyle Bass Strikes Again and Challenges Shire Patents (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Dallas Observer Dallas Erich Spangenberg is Very Proud to be Americas Biggest Patent Troll (2013) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav email threatening IPRs | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav threatened 501 patent IPR petition | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav threatened 501 patent IPR declaration | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav threatened 720 patent obviousness IPR petition | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav threatened 720 patent obviousness IPR declaration | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav threatened 720 patent anticipation IPR petition | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav threatened 720 patent anticipation IPR declaration | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
January 2014 Spangenberg/IPNav patent family tree | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP email threatening IPRs | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP threatened 501 patent IPR petition | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP threatened 501 patent IPR declaration | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP threatened 720 patent obviousness IPR petition | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP threatened 720 patent obviousness IPR declaration | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP threatened 720 patent anticipation IPR petition | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP threatened 720 patent anticipation IPR declaration | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
July 2014 IRDP patent family tree | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Law360 - Shire Drugs Are Next Targets of Hedge Funds AIA Reviews (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Hayman Capital Management, L.P. - Statement of J. Kyle Bass Chief Investment Officer, Hayman Capital Management, L.P. (2015). | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Reuters - U.S. hedge fund plans to take on big pharma over patents (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Pharma, The Catalyst - What They Are Saying, Close Patent Loopholes That Threaten Innovation for Patients (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
IP Watchdog, Senator Coons - Patents Are about the American Dream (2015) | Aug 19, 2015 | EXHIBIT | PATENT OWNER |
Order Authorizing Patent Owner's Motion for Sanctions | Jul 21, 2015 | PAPER | BOARD |
Petitioner's Motion for Admission Pro Hac Vice of Brent E. Routman | Jul 20, 2015 | PAPER | PETITIONER |
Petitioner's Updated Exhibit List | Jul 20, 2015 | PAPER | PETITIONER |
Certificate of Service | Jul 20, 2015 | PAPER | PETITIONER |
Petitioner's Motion for Admission Pro Hac Vice of Ryan J. Fletcher | Jul 20, 2015 | PAPER | PETITIONER |
Petitioner's Updated Exhibit List | Jul 20, 2015 | PAPER | PETITIONER |
Certificate of Service | Jul 20, 2015 | PAPER | PETITIONER |
Declaration of Brent E. Routman in Support of Motion for Admission Pro Hac Vice | Jul 20, 2015 | EXHIBIT | PETITIONER |
Declaration of Ryan J. Fletcher in Support of Motion for Admission Pro Hac Vice | Jul 20, 2015 | EXHIBIT | PETITIONER |
Power of Attorney | May 28, 2015 | PAPER | INDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER. |
Power of Attorney | May 28, 2015 | PAPER | INDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER. |
Related Matters | May 28, 2015 | PAPER | INDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER. |
Notice of Filing Date Accorded to Petition | May 19, 2015 | PAPER | BOARD |
Petition for Inter Partes Review of Patent No. 5,635,517 | May 7, 2015 | PAPER | PETITIONER |
Petitioner's Exhibit List | May 7, 2015 | PAPER | PETITIONER |
Power of Attorney | May 7, 2015 | PAPER | PETITIONER |
U.S. Patent No. 5,635,517 | May 7, 2015 | EXHIBIT | PETITIONER |
Piper et al., Anti-inflammatory immunosuppressive thalidomide analogs_International Journal of Leprosy | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,385,901 | May 7, 2015 | EXHIBIT | PETITIONER |
Agrawal et al., Structure activity relationship studies of thalidomide analogs as anti-inflammatory and immunosuppressive agents | May 7, 2015 | EXHIBIT | PETITIONER |
WO 9420085 to DAmato | May 7, 2015 | EXHIBIT | PETITIONER |
KEITH WALTERS, NATIONAL TOXICOLOGY PROGRAM'S CHEMICAL SOLUBILITY COMPENDIUM | May 7, 2015 | EXHIBIT | PETITIONER |
Declaration of Clayton H. Heathcock, Ph.D. | May 7, 2015 | EXHIBIT | PETITIONER |
Curriculum Vitae of Clayton H. Heathcock, Ph.D. | May 7, 2015 | EXHIBIT | PETITIONER |
Sampaio et al., Thalidomide Selectively Inhibits Tumor Necrosis Factor_Production by Stimulated Human Monocytes | May 7, 2015 | EXHIBIT | PETITIONER |
Carswell et al., An Endotoxin-Induced Serum Factor that Causes Necrosis of Tumors | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Application for Extension of Patent Term | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Original Application | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Notice of Allowance | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Interview Summary | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Request for Ex Parte Reexamination | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,593,990 | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 4,808,402 | May 7, 2015 | EXHIBIT | PETITIONER |
Leibovich et al., Macrophage-induced angiogenesis is mediated by tumor necrosis factor-alpha | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Order Granting Request for Reexamination | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Office Action in Reexamination | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Request for Reconsideration | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Patent Owner Statement | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Declaration of David I. Stirling, Ph.D. | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 File History_Notice of Intent to Issue Reexamination Certificate | May 7, 2015 | EXHIBIT | PETITIONER |
U.S. Patent No. 5,635,517 Reexamination Certificate | May 7, 2015 | EXHIBIT | PETITIONER |
DAmato et al., Thalidomide is an Inhibitor of Angiogenesis | May 7, 2015 | EXHIBIT | PETITIONER |
Koch, The Arene Oxide Hypothesis of Thalidomide Action. | May 7, 2015 | EXHIBIT | PETITIONER |
Thalidomide and Congeners as Anti-inflammatory Agents | May 7, 2015 | EXHIBIT | PETITIONER |
Engelhardt et al., Pomalidomide, Recent Results Cancer Res. | May 7, 2015 | EXHIBIT | PETITIONER |
Schumacher et al., The teratogenic activity of a thalidomide analogue, EM 12, in rabbits, rats, and monkeys | May 7, 2015 | EXHIBIT | PETITIONER |
Sekut et al., Evaluation of the Significance of Elevated Levels of Systemic and Localized Tumor Necrosis Factor in Different Animal Models of Inflammation | May 7, 2015 | EXHIBIT | PETITIONER |