Notice of Refund | Nov 21, 2016 | PAPER | BOARD |
Petitioner's Request for Refund of Post-Institution Fees | Nov 15, 2016 | PAPER | PETITIONER |
Denying Request for Rehearing | Oct 19, 2016 | PAPER | PETITIONER |
IPR2016-00379 Motion for Reconsideration Denying Institution | Jul 29, 2016 | PAPER | PETITIONER |
Decision - Denying Institution of Inter Partes Review | Jul 1, 2016 | PAPER | BOARD |
Order re Pro Hac Vice admission | Jun 1, 2016 | PAPER | BOARD |
Patent Owner's Preliminary Response | Apr 22, 2016 | PAPER | PATENT OWNER |
Brodde_Bisoprolol a Highly Selective B1-Adrenoceptor Antagonist | Apr 22, 2016 | EXHIBIT | PATENT OWNER |
Rimele_Comparison of the beta-adrenoceptor affinity and selectivity of cetamolol | Apr 22, 2016 | EXHIBIT | PATENT OWNER |
Haeusler_Pharmacology of beta-blockers | Apr 22, 2016 | EXHIBIT | PATENT OWNER |
Lopressor (metoprolol tartrate) Prescribing Information | Apr 22, 2016 | EXHIBIT | PATENT OWNER |
Tenormin (atenolol) Prescribing Information | Apr 22, 2016 | EXHIBIT | PATENT OWNER |
Inderal (propranolol hydrochloride) Prescribing Information | Apr 22, 2016 | EXHIBIT | PATENT OWNER |
Order Conduct of the Proceeding | Mar 8, 2016 | PAPER | BOARD |
Notice of Accepting Corrected Petition | Feb 18, 2016 | PAPER | BOARD |
Corrected Petition for Inter Partes Review of U.S. Patent No. 6,545,040 | Jan 20, 2016 | PAPER | PETITIONER |
Petitioner's Unopposed Motion for Pro Hac Vice Admission of Donald Puckett | Jan 20, 2016 | PAPER | PETITIONER |
Petitioner's Unopposed Motion for Pro Hace Vice Admission of John P. Murphy | Jan 20, 2016 | PAPER | PETITIONER |
Petitioner's Updated Exhibit List as of January 20, 2016 | Jan 20, 2016 | PAPER | PETITIONER |
U.S. Patent No. 6,545,040 B1 to Xhonneux, et al. | Jan 20, 2016 | EXHIBIT | PETITIONER |
Excerpts of Prosecution History for the 040 Patent | Jan 20, 2016 | EXHIBIT | PETITIONER |
Excerpts of Ex Parte Reexamination Prosecution History for the 040 Patent | Jan 20, 2016 | EXHIBIT | PETITIONER |
U.S. Patent No. 4,654,362 to Van Lommen et al. | Jan 20, 2016 | EXHIBIT | PETITIONER |
HANDBOOK OF CHROMATOGRAPHY, Vol. II, at 1-101 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Yoshio Okamoto, et al., Optical Resolution of ß-Blockers by HPLC on Cellulose Triphenylcarbamate Derivatives, 15 Chemistry Letters at 1237-1240 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Daniel W. Armstrong, et al., Separation of Drug Stereoisomers by the Formation of ß-Cyclodextrin Inclusion Complexes, 232 SCIENCE at 1132-1135 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Daniel W. Armstrong, Chiral Stationary Phases for High Performance Liquid Chromatographic Separation of Enantiomers | Jan 20, 2016 | EXHIBIT | PETITIONER |
Daniel W. Armstrong, et al., Enantiomeric Separations in Chromatography, 19 CRC Critical Reviews in Analytical Chemistry at 175-190 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Veronika R. Meyer, PRACTICAL HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY | Jan 20, 2016 | EXHIBIT | PETITIONER |
Veronika R. Meyer, PRACTICAL HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY, Ch. 25 at 269-301 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Stig G. Allenmark, CHROMATOGRAPHIC ENANTIOSEPARATION, Ch. 4 at 42-63 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Stig G. Allenmark, CHROMATOGRAPHIC ENANTIOSEPARATION, Ch. 5 at 64-74 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Stig G. Allenmark, CHROMATOGRAPHIC ENANTIOSEPARATION, Ch. 7 at 90-145 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Stig G. Allenmark, CHROMATOGRAPHIC ENANTIOSEPARATION, Ch. 8.3 at 158-177 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Chiral Phase HPLC Columns, Bakerbond, J.T. Baker Research Products | Jan 20, 2016 | EXHIBIT | PETITIONER |
G. Gubitz and S. Mihellyes, Optical Resolution of ß- blocking Agents by Thin-layer Chromatography and High-Performance Liquid Chromatography as Diastereomic R-(--)-1-(1-naphthyl)ethylureas, 314 Journal of Chromatography at 462-466 | Jan 20, 2016 | EXHIBIT | PETITIONER |
W. Lindner, et al., Liquid Chromatographic Separation of Enantiomeric Alkanolamines via Diastereomeric Tartaric Acid Monoesters, 316 Journal of Chromatography at 605- 616 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Jorgen Hermansson, Resolution of Racemic Aminoalcohols ß-Blockers), Amines and Acids as Enantiomeric Derivatives Using a Chiral a1-Acid Glycoprotein Column, 325 Journal of Chromatography at 379-384 | Jan 20, 2016 | EXHIBIT | PETITIONER |
G¿ran Schill, et al., 365 Journal of Chromatography at 73-88 | Jan 20, 2016 | EXHIBIT | PETITIONER |
CYCLOBOND HANDBOOK, Advanced Separation Technologies Inc. | Jan 20, 2016 | EXHIBIT | PETITIONER |
M. Krstulovic, et al., Direct Enantiomeric Separation of Betaxolol with Applications to Analysis of Bulk Drug and Biological Samples, 452 Journal of Chromatography, at 477-483 | Jan 20, 2016 | EXHIBIT | PETITIONER |
CHIRAL SEPARATIONS, (D. Stevenson and I. D. Wilson, eds., 1988) | Jan 20, 2016 | EXHIBIT | PETITIONER |
H. Y. Aboul-Enein and I. Ali, HPLC enantiomeric resolution of nebivolol on normal and reversed amylose based chiral phases, 56 Pharmazie, at 214-216 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Imran Ali and Hassa Y. Aboul-Enein, Enantioseparation of some clinically used drugs by HPLC using cellulose Tris (3,5-dichlorophenylcarbamate) chiral stationary phase, 17 Biomed. Chromatogr. at 113-117 | Jan 20, 2016 | EXHIBIT | PETITIONER |
L. A. Fingerhut, et. al., Health and Disease in the United States, 1 Ann. Rev. Public Health at 1-36 | Jan 20, 2016 | EXHIBIT | PETITIONER |
David S. Goldstein, Plasma Catecholamines and Essential Hypertension | Jan 20, 2016 | EXHIBIT | PETITIONER |
Edward Freis, M.D., Validity of Therapy For Mild Hypertension, 30 Ann. Rev. Med. at 81-89 | Jan 20, 2016 | EXHIBIT | PETITIONER |
L.H. Opie, Hypertension in General Practice, Part I. Examination and Investigation of a Patient with Hypertension, SA MEDICAL JOURNAL at 955-960 | Jan 20, 2016 | EXHIBIT | PETITIONER |
William B. Stason, Opportunities for Improving the Cost- Effectiveness of Antihypertensive Treatment, 81 The American Journal of Medicine at 45-49 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Van de Water, et al. Cardiovascular effects of dl-nebivolol and its enantiomers, 156 European Journal of Pharmacology at 95- 103 | Jan 20, 2016 | EXHIBIT | PETITIONER |
David B. Bylund, Adrenergic Receptors, The Adrenergic Receptors in the 21st Century, Chapter 1 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Noboru Toda, et al., Selectivity and Steric Effects of Metoprolol Isomers on Isolated Rabbit Atria, Arteries and Tracheal Muscles, 207 The Journal of Pharmacology and Experimental Therapeutics at 311-19 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Keitaro Hashimoto, The Relation Between the Current Underlying Pacemaker Activity and Beta-Adrenoceptors in Cardiac Purkinje Fibres | Jan 20, 2016 | EXHIBIT | PETITIONER |
J. Kaumann and J. R. Blinks, Stimulant and Depressant Effects of ß-Adrenoceptor Blocking Agents on Isolated Heart Muscle | Jan 20, 2016 | EXHIBIT | PETITIONER |
James E. Clifton, et al., Arylethanolamines Derived from Salicylamide with a- and ß-Adrenoceptor Blocking Activities. Preparation of Labetalol, Its Enantiomers, and Related Salicylamides, 25 Journal of Medicinal Chemistry at 670-679 | Jan 20, 2016 | EXHIBIT | PETITIONER |
David E. McClure, et al., 26 Journal of Medicinal Chemistry at 649-657 | Jan 20, 2016 | EXHIBIT | PETITIONER |
A.B. Jeppsson, et al.,Steric Aspects of Agonism and Antagonism at ß-adrenoceptors, 54 Acta Pharmacol. et Toxicol. at 285-291 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Arthur A. Hancock, Analysis of the Hypotensive Effects of Medroxalol and Its Enantioners, Clin. and Exper. Hyper.-Theory and Practice, A6(3), at 659-684 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Kazuo Honda, et al., 41 Japan. J. Pharmacol. at 459-466 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Petrus J. Pauwels, et al., The Receptor Binding Profile of the New Antihypertensive Agent Nebivolol and Its Stereoisomers Compared With Various ß-Adrenergic Blockers, 34 Molecular Pharmacology at 843-861 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Van de Water, et al., 11 Journal of Cardiovascular Pharmacology at 552-563 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Raymond Xhonneux, et al., The l-enantiomer of nebivolol potentiates the blood pressure lowering effect of the denantiomer, 181 European Journal of Pharmacology at 261-265 | Jan 20, 2016 | EXHIBIT | PETITIONER |
G. Van Lomen, et al., Synthesis and Pharmacological Properties of Nebivolol, a new antihypertensive compound, 45 Journal de pharmacie de Belgique at 355- 360 | Jan 20, 2016 | EXHIBIT | PETITIONER |
M. Midol-Monet, 43 J. Pharm. Pharmacol. at 504-509 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Van Peer, et al., Clinical Pharmacokinetics of Nebivolol A Review, 3 Drug Investigation at 25-30 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Carsten D. Siebert, et al., Stereochemical Comparison of Nebivolol with other ß-Blockers, 20 Chirality at 103-109 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Irving W. Wainer and Thomas D. Doyle, Stereisomeric Separations, 2 LC Magazine | Jan 20, 2016 | EXHIBIT | PETITIONER |
Actavis UK Limited and Janssen Pharmaceutica N.V., Case No HC0700 572,In the High Court of Justice, Chancery Division, Patent Court, 2008 EWHC 1422 | Jan 20, 2016 | EXHIBIT | PETITIONER |
Declaration under 37 CFR 42.53(a) by Dr. Daniel W. Armstrong | Jan 20, 2016 | EXHIBIT | PETITIONER |
Daniel W. Armstrong Curriculum Vitae | Jan 20, 2016 | EXHIBIT | PETITIONER |
Declaration under 37 CFR 42.53(a) by Ronald W. Millard, Ph.D. | Jan 20, 2016 | EXHIBIT | PETITIONER |
Ronald Wesley Millard Curriculum Vitae | Jan 20, 2016 | EXHIBIT | PETITIONER |
Declaration of Donald Puckett in Support of Unopposed Motion for Pro Hac Vice Admission | Jan 20, 2016 | EXHIBIT | PETITIONER |
Declaration of John P. Murphy in Support of Unopposed Motion for Pro Hac Vice Admission | Jan 20, 2016 | EXHIBIT | PETITIONER |
Power of Attorney | Jan 12, 2016 | PAPER | INDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER. |
Related Matters | Jan 12, 2016 | PAPER | INDICATES ARTIFACT WAS SUBMITTED ON BEHALF OF POTENTIAL_PATENT OWNER. |
Notice of Filing Date Accorded to Petition | Jan 4, 2016 | PAPER | BOARD |
Petition for Inter Partes Review | Dec 22, 2015 | PAPER | PETITIONER |
Power of Attorney | Dec 22, 2015 | PAPER | PETITIONER |
EXPUNGED | Dec 22, 2015 | EXHIBIT | PETITIONER |
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