Roxane Laboratories, Inc. et al. vs Novartis AG

Final Written Decision (IPR2016-00084)

EXPUNGED

Decision - Dismissing Requests for Rehearing

Petitioners' Updated Mandatory Notice

Petitioner's Request for Rehearing of the Board's Decision Denying Joinder

Patent Owner's Response To Petitioners' Requests For Reconsideration

EXPUNGED

Joined with IPR2016-00084 per Motion (Paper 17)

Ex. 2404

Patent Owner's Preliminary Response

Patent Owner's Exhibit List 1

Ex. 2401

Ex. 2402

Ex. 2403

Petitioner's Reply in Support of its Motion for Joinder

Order - re Due Date for Preliminary Response

Patent Owner's Opposition To Motion For Joinder

Petitioner's Transmittal Letter Accompanying Submission of Exhibit 1032

Petitioner's Second Amended Exhibit List

Transcript of June 17, 2016 Conference Call

Patent Owner's Mandatory Notices

Power of Attorney

Petitioner's Transmittal Letter Accompanying Submission of Exhibit 1031

Petitioner's Amended Exhibit List

Transcript of June 1, 2016 Conference Call

Notice Of Filing Date Accorded To Petition

Power of Attorney

Petition for Inter Partes Review of U.S. Patent No. 5,665,772 Under 35 U.S.C. 311-319 and 37 C.F.R. 42.100 et seq.

Motion for Joinder Pursuant to 35 USC 315(c) and 37 CFR 42.122(b)

U.S. Patent No. 5,665,772 (the 772 Patent)

File History for the 772 Patent

Declaration of William L. Jorgensen, Ph.D. in Support of Petition for Inter Partes Review of U.S. Patent No. 5,665,772

Curriculum Vitae of William L. Jorgensen

Randall Ellis Morris, Rapamycins - Antifungal, Antitumor, Antiproliferative, and Immunosuppressive Macrolides, 6 TRANSPLANTATION REVIEWS 39 (1992) (Morris)

Gregory D. Van Duyne et al., Atomic Structure of the Rapamycin Human Immunophilin FKBP-12 Complex, 113 J. AM. CHEMICAL SOCY 7433 (1991) (Van Duyne)

Samuel H. Yalkowsky, Estimation of Entropies of Fusion of Organic Compounds, 18 INDUS. and ENGG CHEMISTRY FUNDAMENTALS 108 (1979) (Yalkowsky)

Thomas L. Lemke, Chapter 16 - Predicting Water Solubility, REVIEW OF ORGANIC FUNCTIONAL GROUPS 113 (2d ed. 1988)

U.S. Patent No. 5,233,036 (Hughes)

U.S. Patent No. 4,650,803 (Stella)

U.S. Patent No. 5,100,883 (Schiehser)

Stuart L. Schreiber, Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands, 251 SCI. 283 (1991) (Schreiber)

Joseph B. Moon and W. Jeffrey Howe, Computer Design of Bioactive Molecules - A Method for Receptor-Based de Novo Ligand Design, 11 PROTEINS - STRUCTURE, FUNCTION, and GENETICS 314 (1991) (Moon)

Hans-Joachim Böhm, LUDI- rule-based automatic design of newsubstituents for enzyme inhibitor leads, 6 J. COMPUTER-AIDED MOLECULAR DESIGN 593 (1992) (Böhm)

Silverman, Chapter 2- Drug Discovery, Design, and Development, THE ORGANIC CHEMISTRY OF DRUG DESIGN and ACTION 4 (1992) (Silverman)

Julianto Pranata and William L. Jorgensen, Computational Studies on FK506 Conformational Search and Molecular Dynamics Simulation in Water, 113 J. AM. CHEMICAL SOCY 9483 (1991)

William L. Jorgensen, Rusting of the Lock and Key Model for Protein-Ligand Binding, 254 SCI. 954 (1991)

Modesto Orozco et al., Mechanism for the Rotamase Activity of FK506 Binding Protein from Molecular Dynamics Simulations, 32 BIOCHEMISTRY 12864 (1993)

Michelle L. Lamb and William L. Jorgensen, Investigations of Neurotrophic Inhibitors of FK506 Binding Protein via Monte Carlo Simulations, 41 J. MED. CHEMISTRY 3928 (1998)

Michelle L. Lamb et al., Estimation of Binding Affinities of FKBP12 Inhibitors Using a Linear Response Method, 7 BIOORGANIC and MEDICINAL CHEMISTRY 851 (1999)

Thomas W. Bell, Construction of a Soluble Heptacyclic Terpyridine, 51 J. ORGANIC CHEMISTRY 764 (1986) (Bell)

M. Ballauff, Phase Equilibria in Rodlike Systems with Flexible Side Chains, 19 MACROMOLECULES 1366 (1986) (Ballauff)

R. Stern et al., Rigid rod polymers with flexible side chains, 32 POLYMER 2096 (1991) (Stern)

Michael G. Rossmann et al., Three-Dimensional Coordinates from Stereodiagrams of Molecular Structures, B36 ACTA CRYSTALLOGRAPHICA 819 (1980) (Rossmann)

William L. Jorgensen and Julian Tirado-Rives, The OPLS Potential Functions for Proteins. Energy Minimizations for Crystals of Cyclic Peptides and Crambin, 110 J. AM. CHEMICAL SOCY 1657 (1988)

Julian Tirado-Rives and William L. Jorgensen, Molecular Dynamics of Proteins with the OPLS Potential Functions. Simulation of the Third Domain of Silver Pheasant Ovomucoid in Water, 112 J. AM. CHEMICAL SOCY 2773 (1990)

Michael L. Connolly, Solvent-Accessible Surfaces of Proteins and Nucleic Acids, 221 SCI. 709 (1983)

Yoshihiko Nisibata et al., Automatic Creation of Drug Candidate Structures Based on Receptor Structure. Starting Point for Artificial Lead Generation., 47 TETRAHEDRON 8985 (1991)

Stephen W. Michnick et al., Solution Structure of FKBP, a Rotamase Enzyme and Receptor for FK506 and Rapamycin, 252 SCI. 836 (1991)

Certificate of Correction for U.S. Patent No. 5,665,772