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Patent Owner Mandatory Notice Information

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Ex. 1066- Declaration of Lisa M. Ferri in Support of Motion to Appear PHV

Ex. 1067- Professional Profile of Lisa M. Ferri

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PETITION FOR INTER PARTES REVIEW OF U.S. PATENT NO. 8,604,204

U.S. Patent No. 8,614,204 (filed June 3, 2004)

Declaration of Dr. Tomas Ganz, Ph.D., M.D.

Part 1 - File history of U.S. Patent No. 8,614,204 (filed July 12, 2010)

Part 2 - File history of U.S. Patent No. 8,614,204 (filed July 12, 2010)

Part 3 - File history of U.S. Patent No. 8,614,204 (filed July 12, 2010)

International Patent Application Publication No. WO02/074981 (filed Mar. 21, 2002) (Maxwell 2002)

Ivan et al., Biochemical purification and pharmacological

Epstein et al., C. elegans EGL-9 and Mammalian Homologs

Jaakkola et al., Targeting of HIF-a to the von Hippel-Lindau Ubiquitylation

Semenza, Hypoxia inducible factor

Semenza, HIF-1 and human disease one highly involved factor

U.S. Provisional Patent Application No. 60/476,704 (filed June 6, 2003) (the 704 application)

U.S. Provisional Patent Application No. 60/566,237 (filed Apr. 29, 2004) (the 237 application)

U.S. Provisional Patent Application No. 60/599,488 (filed Apr. 29, 2004) (the 488 application)

U.S. Provisional Patent Application No. 60/569,797 (filed May 10, 2004) (the 797 application)

Raja et al., In vivo studies on the relationship between intestinal iron

Mendel, Studies on Iron Absorption. I. The Relationships Between the Rate of Erythropoiesis

Strohmeyer et al., Effects of hypoxia on iron absorption and mobilization in the rat

Roy et al., 2002 E. Mead Johnson Award for Research in Pediatrics Lecture

Fairbanks et al., Iron Metabolism

Eschbach et al., Correction of the Anemia of End Stage Renal Disease with Recombinant Human Erythropoietin

Cavill et al., Correspondence - Functional Iron Deficiency

Cantrill et al., Iron Absorption from the Intestinal Tract - The Influence of the Haemoglobin Concentration and of Hypoxia

Taylor et al., Effects of hypoxia on iron absorption in rats

Wang et al., General involvement of hypoxia inducible factor 1 in transcriptional response to hypoxia

Huang et al., Regulation of hypoxia-inducible factor 1

Ivan et al., HIFa Targeted for VHL-Mediated Destruction by Proline Hydroxylation

U.S. Patent Application Publication No. 2004/0146964 (PCT filed Mar. 21, 2002) (the Maxwell U.S. Application)

Bickel, et al., Selective Inhibition of Hepatic Collagen Accumulation in Experimental Liver Fibrosis in Rats by a New Prolyl 4-Hydroxylase Inhibitor

Ganz, Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation

Fairbanks et al., Iron Deficiency

Abboud et al., A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

Canonne-Hergaux et al., Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

Canonne-Hergaux et al., Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders

Donovan et al., Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

Fleming et al., Microcytic anaemia mice have a mutation in Nramp2

Harris et al., Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

Huebers et al., The Physiology of Transferrin and Transferrin Receptors

Jandl et al., The Plasma-to-Cell Cycle of Transferrin

Masson et al., HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O2 levels

McKie et al., A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

McKie et al., An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

Nemeth et al., Hepcidin, a putative mediator of anemia of inflammation

Nemeth et al., IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin

Ratcliffe, From Erythropoietin to Oxygen Hypoxia-Inducible Factor Hydroxylases and the Hypoxia Signal Pathway

Vulpe et al., Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

Semenza, Gregg, Hypoxia-inducible factor 1 oxygen homeostasis and disease pathophysiology,

Beutler, Ernest, Production and Destruction of Erythrocytes

Lee et al., The Human Nramp2 Gene Characterization of the Gene Structure, Alternative Splicing, Promoter Region and Polymorphisms

Lok et al., Identification of a Hypoxia Response Element in the Transferrin Receptor Gene

Part 1 - Filed Specification of Application No. 10/861,590

Part 2 - Filed Specification of Application No. 10/861,590

Part 3 - Filed Specification of Application No. 10/861,590

Erslev, A.J., Anemia of Chronic Disease

Testa, Ugo, Recent developments in the understanding of iron metabolism

Iron Metabolism, Anemias Diagnosis and Therapy - Novel Concepts for Renal Anemias and Rheumatoid Arthritis

Non-Final Rejection (Sept. 14, 2012) (excerpt from '204 File History)

Non-Final Rejection (Mar. 25, 2009) (excerpt from '204 File History)

Final Rejection (Dec. 30, 2009 ) (excerpt from '204 File History)

Final Rejection dated Mar. 10, 2011 (excerpt from '204 File History)

Applicant Initiated Interview Summary Apr. 23, 2013

Notice of Allowability (Sept. 13, 2013) excerpt from '204 File History)

European Patent No. 1633333, Declaration of Lynda Szczech (Szczech Decl.)

Semenza, Gregg, Perspectives on Oxygen Sensing, Cell, 98 281-284 (Aug. 6, 1999) (Semenza 1999)

European Patent No. 1633333, Patentee's Response to Oppositions (333 Opposition)

European Patent No. 2322153, Patentee's Response to Oppositions (153 Opposition)

European Patent No. 2322155, Patentee's Response to Oppositions (155 Opposition)

Listing of the documents reviewed and relied upon by Dr. Tomas Ganz in preparing his Declaration (Ex. 1002)

Curriculum Vitae of Tomas Ganz, Ph.D., M.D.