Petitioner Pfizer's Notice of Appeal | Jan 30, 2019 | PAPER | PETITIONER |
Final Written Decision | Nov 28, 2018 | PAPER | BOARD |
Hearing Transcript | Nov 27, 2018 | PAPER | BOARD |
ORDER Granting Petitioner's Unopposed Motions to Withdraw Counsel | Aug 14, 2018 | PAPER | BOARD |
Petitioner's Unopposed Motion For Counsel To Withdraw | Aug 8, 2018 | PAPER | PETITIONER |
Petitioner's Objections to Pat. Owner's Demonstratives | Jul 31, 2018 | PAPER | PETITIONER |
Patent Owner's Objections to Petitioner's Demonstratives | Jul 31, 2018 | PAPER | PATENT OWNER |
Petitioner's Updated Mandatory Notice | Jul 27, 2018 | PAPER | PETITIONER |
Petitioner's Updated Power of Attorney | Jul 27, 2018 | PAPER | PETITIONER |
Order - 37 C.F.R. 42.70 | Jul 20, 2018 | PAPER | BOARD |
Petitioner's Reply To Opposition To Motion To Exclude Evidence | Jul 12, 2018 | PAPER | PETITIONER |
Petitioner's Updated Power Of Attorney Appointing Additional Counsel | Jul 11, 2018 | PAPER | PETITIONER |
Petitioner's Updated Mandatory Notice | Jul 11, 2018 | PAPER | PETITIONER |
Petitioner's Authorized Response To Patent Owner's Statement Regarding Petitioner's Reply Papers | Jul 5, 2018 | PAPER | PETITIONER |
Petitioner's Response To Patent Owner's Motion For Observations | Jul 5, 2018 | PAPER | PETITIONER |
EX2302 - Wieland | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2303 - Markussen | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2301 - Lin | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2304 - Fuller | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2305 - Schiebel | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2306 - Vedantham | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2307 - Winters | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
EX2308 - Declaration of Saurabh Gupta | Jul 5, 2018 | EXHIBIT | PATENT OWNER |
Patent Owner's Opposition to Petitioner's Motion to Exclude | Jul 5, 2018 | PAPER | PATENT OWNER |
Petitioner's Motion To Exclude Evidence | Jun 19, 2018 | PAPER | PETITIONER |
Petitioner's Request For Oral Hearing | Jun 19, 2018 | PAPER | PETITIONER |
Patent Owner's June 19, 2018 Exhibit List | Jun 19, 2018 | PAPER | PATENT OWNER |
EX2201 - Lin | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
EX2204 - Fuller | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
EX2205 - Schiebel | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
EX2207 - Winters | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
Patent Owner's Authorized Statement Regarding Petitioner's Reply Papers Beyond the Proper Scope and Improper Incorporation by Reference | Jun 19, 2018 | PAPER | PATENT OWNER |
Patent Owner's Motion for Observations on Cross Examination | Jun 19, 2018 | PAPER | PATENT OWNER |
EX2020 - Deposition Transcript of Todd M. Przybycien, Ph.D. | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
EX2202 - Wieland | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
EX2203 - Markussen | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
EX2206 - Vedantham | Jun 19, 2018 | EXHIBIT | PATENT OWNER |
Patent Owner's Request for Oral Argument | Jun 19, 2018 | PAPER | PATENT OWNER |
Petitioner's Objections To Exhibits | Jun 18, 2018 | PAPER | PETITIONER |
Petitioner's Service Of Supplemental Evidence | Jun 15, 2018 | PAPER | PETITIONER |
Petitioner's Updated Exhibit List (As Of June 15, 2018) | Jun 15, 2018 | PAPER | PETITIONER |
Patent Owner's Objections to Evidence | Jun 1, 2018 | PAPER | PATENT OWNER |
Petitioner's Unopposed Motion For Counsel To Withdraw | May 31, 2018 | PAPER | PETITIONER |
Notice of Deposition of Todd M. Przbycien, Ph.D. | May 29, 2018 | PAPER | PATENT OWNER |
Petitioner's Updated Exhibit List As of May 24, 2018 | May 24, 2018 | PAPER | PETITIONER |
Ex. 1027 - Updated Formulas and Calculations prepared by Todd M. Pryzbycien in response to Dr. Cramer's Direct Testimony | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1028 - R. D. Lillie, "Chapter 21: Buffers and Buffer Tables" in Histopathologic Technic, 260-266 (1948) ("Lillie") | May 24, 2018 | EXHIBIT | PETITIONER |
Petitioner's Reply To Patent Owner's Response | May 24, 2018 | PAPER | PETITIONER |
Ex, 1029 - Vincent S. Stoll & John S. Blanchard, "Buffers: Principles and Practice," Methods in Enzymology, 182:24-38 (1990) ("Stoll") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1030 - Ghose et al., "Antibody Variable Region Interactions with Protein A:Implications for the Development of Generic Purification Processes," Biotech., 92(6):665-637 ("Cramer 2005") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1032 - Ghose et al., "Evaluation and comparison of alternatives to Protein A chromatography Mimetic and hydrophobic charge induction chromatographic stationary phases," J. Chromatography A, 1122:144-152 (2006) ("Cramer 2006") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1035 - Deposition Transcript of Kirston Koths, Ph.D., taken on May 16, 2018 | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1041 - Promega, "Chapter 15: Buffers for Biochemical Reactions" in Protocols & Applications Guide 15-1¿¿¿15-5 (last revised 12/12), ("Promega") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1042 - European Application No. 03795400.5 published as EP 1561756 B1 | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1043 - Additional Excerpts from the Prosecution File History of European Application No. 02703958.5, published as EP 1380589 | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1051 - Ghose et al., "Protein A Affinity Chromatography for Capture and Purification of Monoclonal Antibodies and Fc-Fusion Proteins:Practical Considerations for Process Development," (Abhinav A.Shukla et al., eds.) 463-489 (2007) ("Ghose") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1031 - Ghose et al., "Binding Capacity Differences for Antibodies and Fc-Fusion Proteins on Protein A Chromatographic Materials," Biotech.& Bioeng'g, 96(4): 768-778 (2007) ("Cramer 2007") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1033 - Pete Gagnon, "Chapter 4: Ion Exchange Chromatography," in Purification Tools for Monoclonal Antibodies, 57-86 (1996) ("Gagnon I") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1034 - Deposition Transcript of Steven M. Cramer, Ph.D., taken on May 4, 2018 | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1036 - Declaration of Todd M. Przybycien, Ph.D. in support of Petitioner's Reply to Patent Owner's Response | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1037 - G. Gomori, "Preparation of Buffers for Use in Enzyme Studies," in 1 Methods in Enzymology (Sidney P. Colowick & Nathan O. Kaplan, eds.) (1955) ("Gomori") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1038 - Chandra Mohan, "Buffers: A guide for the Preparation and Use of
Buffers in Biological Systems," 2006, ("Mohan") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1040 - Excerpts from Rex. M.C. Dawson et al., Data for Biochemical Research 418-448 (1986) ("Dawson") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1044 - Additional Excerpts from the Prosecution File History of European Application No. 10011215.0, published as EP 2336149 | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1045 - Pete Gagnon "Chapter 17: Polishing Methods for Monoclonal IgG Purification," in Process Scale Bioseparations for the Biopharmaceutical Industry (Abhinav A. Shukla et al., eds.) (2007) ("Gagnon II") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1046 - Sanchayita Ghose et al., "pH Transitions in Ion-Exchange Systems:Role in the Development of a Cation-Exchange Process for a Recombinant Protein," Biotechn. Prog., 18:530-537 (2002) ("Ghose") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1047 - Determination of Theoretical Wash Buffer Contamination and Effects on Total Molarity for the Adjusted Sample of Shadle Appendix prepared by Todd M. Pryzbycien | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1048 - Justin T. McCue et al., "Evaluation of Protein-A Chromatography Media," J. Chromatography A, 989(1):139-153 (2003) ("McCue") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1049 - V. Vitagliano & P. A. Lyons, "Diffusion Coefficients for Aqueous Solutions of Sodium Chloride and Barium Chloride," J. Am. Chem. Soc'y, 78:1549-1552 (1956) ("Vitagliano") | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1050 - Octave Levenspiel, "Chapter 64:The Dispersion Model," The Chemical Reactor Omnibook 64.1-64.19 (1979) | May 24, 2018 | EXHIBIT | PETITIONER |
Ex. 1052 - Brian Kelley, "Industrialization of mAb Production Technology: The Bioprocessing Industry at a Crossroads," mAbs 1(5):443-452 (2009) ("Kelley") | May 24, 2018 | EXHIBIT | PETITIONER |
Notice of Deposition of Harry G. Brittain PH.D | Apr 4, 2018 | PAPER | PETITIONER |
Notice of Deposition of Kirston Koths, PH.D | Apr 4, 2018 | PAPER | PETITIONER |
Notice Of Deposition Of Steven M. Cramer, PH.D. | Mar 28, 2018 | PAPER | PETITIONER |
Petitioner's Unopposed Motion For Counsel To Withdraw | Mar 26, 2018 | PAPER | PETITIONER |
Patent Owner's Objections to Evidence | Mar 22, 2018 | PAPER | PATENT OWNER |
Ex. 1026 - Updated Formulas and Calculations prepared by Todd M.
Przybycien on January 24, 2018 | Mar 19, 2018 | EXHIBIT | PETITIONER |
Petitioners Updated List of Exhibits (as of March 19, 2018) | Mar 19, 2018 | PAPER | PETITIONER |
Order Conduct of the Proceeding | Mar 19, 2018 | PAPER | BOARD |
Petitioner's Objections To Exhibits | Mar 5, 2018 | PAPER | PETITIONER |
EX2004 - Pathak | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2005 - Roth | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2006 - Khawli | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2007 - Singla | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2008 - Arosio | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2009 - CRC Handbook | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2010 - Yigzaw | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2012 - Skamris | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2014 - Deposition Transcript of Todd M. Przybycien | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2003 - Przybycien | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2011 - Hou | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2013 - Vazquez-Rey | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2019 - Harry G. Brittain, Ph.D. Declaration | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
Patent Owner's Response | Feb 26, 2018 | PAPER | PATENT OWNER |
EX2015 - Steven M. Cramer, P.h.D Declaration | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2016 - Kirston Koths, P.h.D. Declaration | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2017 - Declaration of Megan Raymond | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
EX2018 - Experimental Notebook Pages of Dr. Harry G. Brittain | Feb 26, 2018 | EXHIBIT | PATENT OWNER |
Joint Stipulation to Modify Due Dates 1 to 3 | Feb 5, 2018 | PAPER | PATENT OWNER |
Notice of Deposition of Todd M. Przybycien | Jan 12, 2018 | PAPER | PATENT OWNER |
Ex. 1022 - Declaration of Eimeric Reig-Plessis | Jan 5, 2018 | EXHIBIT | PETITIONER |
Ex. 1023 - Declaration of Sharick Naqi | Jan 5, 2018 | EXHIBIT | PETITIONER |
Petitioner's Unopposed Motion For PHV Admission Of Charles B. Klein, Eimeric Reig-Plessis, Sharick Naqi, Ilan Wurman, and Matthew J. Mezger | Jan 5, 2018 | PAPER | PETITIONER |
Ex. 1021 - Declaration of Charles B. Klein | Jan 5, 2018 | EXHIBIT | PETITIONER |
Ex. 1024 - Declaration of Ilan Wurman | Jan 5, 2018 | EXHIBIT | PETITIONER |
Ex. 1025 - Declaration of Matthew J. Mezger | Jan 5, 2018 | EXHIBIT | PETITIONER |
Petitioner's Updated Exhibit List (as of January 5, 2018) | Jan 5, 2018 | PAPER | PETITIONER |
Petitioner's Service of Supplemental Evidence '815 | Jan 2, 2018 | PAPER | PETITIONER |
PETITIONER'S UPDATED EXHIBIT LIST (AS OF JANUARY 2, 2018) | Jan 2, 2018 | PAPER | PETITIONER |
PETITIONER'S UPDATED POWER OF ATTORNEY | Dec 19, 2017 | PAPER | PETITIONER |
PETITIONER'S UPDATED MANDATORY NOTICE | Dec 19, 2017 | PAPER | PETITIONER |
Patent Owner's Objections to Evidence | Dec 15, 2017 | PAPER | PATENT OWNER |
Petitioner's Objections to Patent Owner Exhibits | Dec 15, 2017 | PAPER | PETITIONER |
Trial Instituted Document | Dec 1, 2017 | PAPER | BOARD |
Scheduling Order | Dec 1, 2017 | PAPER | BOARD |
Patent Owner Preliminary Response | Sep 5, 2017 | PAPER | PATENT OWNER |
Exhibit 2001 - Excerpt from EP03795400 File History | Sep 5, 2017 | EXHIBIT | PATENT OWNER |
Exhibit 2002 - Declaration of Megan Raymond | Sep 5, 2017 | EXHIBIT | PATENT OWNER |
Patent Owner Mandatory Notice | Jun 9, 2017 | PAPER | PATENT OWNER |
Power of Attorney | Jun 9, 2017 | PAPER | PATENT OWNER |
Notice of Accord Filing Date | Jun 5, 2017 | PAPER | BOARD |
Ex. 1003 - International Publication No. WO 95/22389 to Shadle et al. ("WO '389") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1005 - Excerpts from the Prosecution File History of U.S. Patent No. 7,927,815 | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1001 - Takeda et al., U.S. Patent No. 7,927,815 B2, "Protein Purification Method," (issued Apr. 19, 2011) ("the '815 patent") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1004 - European Application No. 02703958.5, published as EP 1380589 ("EP '589") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1006 - Excerpts from the Prosecution File History of European Application No. 02703958.5, published as EP 1380589 | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1008 - Shadle et al., U.S. Patent No. 5,429,746, "Antibody Purification" (issued Jul. 4, 1995) ("the '746 patent") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1010 - Jerry M. Martin et al., "Cartridge Filtration for Biotechnology," in Bioprocessing Engineering: Systems, Equipment and Facilities (Bjorn K. Lydersen et al., eds.) 317-370 (1994) ("Martin") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1012 - Anne R. Karrow et al., "Buffer Capacity of Biologics - From Buffer Salts to Buffering by Antibodies," Biotechnol. Prog., 29(2):480-492 (2013) ("Karrow") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1015 - Gerald D. Fasman, "Practical Handbook of Biochemistry and Molecular Biology," 545-549, 554 (1989) ("Fasman") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1017 - Metrohm conductivity measurement monograph 2004 | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1013 - Alexander Apelblat and Josef Barthel, "Conductance Studies on Aqueous Citric Acid," Z. Naturforsch 46(a):131-140 (1991) ("Apelblat I") | May 19, 2017 | EXHIBIT | PETITIONER |
PFIZER, INC.'S POWER OF ATTORNEY | May 19, 2017 | PAPER | PETITIONER |
Ex. 1018 - Handbook of Chemistry and Physics | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1009 - Robert K. Scopes, PROTEIN PURIFICATION: PRINCIPLES AND PRACTICE 44 (1987) ("Scopes") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1019 - EP2336149A1 | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1007 - Formulas and Calculations Appendix prepared by Todd M. Przybycien on May 15, 2017 | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1016 - Protocol for Citrate Buffer Conductivity Measurements prepared by Todd M. Przybycien on May 8, 2017 ("Protocol") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1011 - Excerpts from the Prosecution File History of European Application No. 10011215.0, published as EP 2336149 ("EP '149") | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1002 - Declaration of Todd M. Przybycien, Ph.D. | May 19, 2017 | EXHIBIT | PETITIONER |
Ex. 1014 - Alexander Apelblat, Citric Acid 13-212 (2014) ("Apelblat II") | May 19, 2017 | EXHIBIT | PETITIONER |
PETITION FOR INTER PARTES REVIEW '815 | May 19, 2017 | PAPER | PETITIONER |