The detailed information for PTAB case with proceeding number IPR2017-01913 filed by Fresenius Kabi USA, LLC against AstraZeneca AB on Aug 4, 2017. This includes filing dates, application numbers, tech centers, patent numbers, and current case status.

Case Details

Proceeding Number
IPR2017-01913
Filing Date
Aug 4, 2017
Petitioner
Fresenius Kabi USA, LLC
Respondent
AstraZeneca AB
Status
Institution Denied
Respondent Application Number
12285887
Respondent Tech Center
1600
Respondent Patent Number
8329680
Institution Decision Date
Dec 11, 2017

Proceeding Documents

The table below shows documents filed in the case, listing each document name, filing date, document type, and filing party. Tracking these filings indicates the activity of the parties involved in the case, and the types of documents filed can provide insights into the legal strategies being employed.


Document NameFiling DateCategoryFiling Party

Alert me when new update on this case

Notice of Refund

Feb 1, 2018PAPERBOARD

Petitioner's Refund Request

Jan 24, 2018PAPERPETITIONER

Decision - Denying Institution of Inter Partes Review

Dec 11, 2017PAPERBOARD

Amendment to the Claims, Patent Appl. No. 12/285,887

Dec 11, 2017EXHIBITBOARD

Illum Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Robertson Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Sawchuk Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Di Leo 2010

Nov 17, 2017EXHIBITPATENT OWNER

Ohno 2010

Nov 17, 2017EXHIBITPATENT OWNER

Greenlee 2000

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 1996

Nov 17, 2017EXHIBITPATENT OWNER

Hortobagyi Cancer Investigation 1998

Nov 17, 2017EXHIBITPATENT OWNER

Johnston 1997

Nov 17, 2017EXHIBITPATENT OWNER

Pritchard 1997

Nov 17, 2017EXHIBITPATENT OWNER

Howell 1992

Nov 17, 2017EXHIBITPATENT OWNER

Jordan 1995

Nov 17, 2017EXHIBITPATENT OWNER

Morrow 1993

Nov 17, 2017EXHIBITPATENT OWNER

Wiebe 1993

Nov 17, 2017EXHIBITPATENT OWNER

Jordan Supp. 1992

Nov 17, 2017EXHIBITPATENT OWNER

Jordan 1992

Nov 17, 2017EXHIBITPATENT OWNER

Minton 1999

Nov 17, 2017EXHIBITPATENT OWNER

Patent Owner's Preliminary Response to Petition for Inter Partes Review of U.S. Patent No. 8,329,680

Nov 17, 2017PAPERPATENT OWNER

Di Leo 2014

Nov 17, 2017EXHIBITPATENT OWNER

Pritchard 2010

Nov 17, 2017EXHIBITPATENT OWNER

Fornier 1999

Nov 17, 2017EXHIBITPATENT OWNER

Jordan Supp. 1995

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar Clin. Oncol. 1998

Nov 17, 2017EXHIBITPATENT OWNER

Osborne 2002

Nov 17, 2017EXHIBITPATENT OWNER

Fallowfield 2006

Nov 17, 2017EXHIBITPATENT OWNER

Robertson SABCS 2014

Nov 17, 2017EXHIBITPATENT OWNER

Vergote 2003

Nov 17, 2017EXHIBITPATENT OWNER

Agrawal 2009

Nov 17, 2017EXHIBITPATENT OWNER

Gupta Ch. 2

Nov 17, 2017EXHIBITPATENT OWNER

Grese 1998

Nov 17, 2017EXHIBITPATENT OWNER

Hortobagyi New Eng. J. Med. 1998

Nov 17, 2017EXHIBITPATENT OWNER

Masamura 1994

Nov 17, 2017EXHIBITPATENT OWNER

Kelloff 1998

Nov 17, 2017EXHIBITPATENT OWNER

Dukes 1994

Nov 17, 2017EXHIBITPATENT OWNER

Howell 2002

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2001

Nov 17, 2017EXHIBITPATENT OWNER

Robertson Clin. Ther. 2003

Nov 17, 2017EXHIBITPATENT OWNER

Labrie 2004

Nov 17, 2017EXHIBITPATENT OWNER

Van de Velde 1996

Nov 17, 2017EXHIBITPATENT OWNER

Labrie 1999

Nov 17, 2017EXHIBITPATENT OWNER

Hortobagyi 1998

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 1999

Nov 17, 2017EXHIBITPATENT OWNER

Hortobagyi 1997

Nov 17, 2017EXHIBITPATENT OWNER

Dowsett 1995

Nov 17, 2017EXHIBITPATENT OWNER

Hayes 1995

Nov 17, 2017EXHIBITPATENT OWNER

Howell 1997

Nov 17, 2017EXHIBITPATENT OWNER

Haarstad 1992

Nov 17, 2017EXHIBITPATENT OWNER

AACR Journals Online

Nov 17, 2017EXHIBITPATENT OWNER

McLeskey Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Innovative Research

Nov 17, 2017EXHIBITPATENT OWNER

PDR 1999 Nolvadex

Nov 17, 2017EXHIBITPATENT OWNER

PDR 1999 Femara

Nov 17, 2017EXHIBITPATENT OWNER

Rauschning 1994

Nov 17, 2017EXHIBITPATENT OWNER

Thomas 1993

Nov 17, 2017EXHIBITPATENT OWNER

July 14 Trial Tr.

Nov 17, 2017EXHIBITPATENT OWNER

Bratherton 1984

Nov 17, 2017EXHIBITPATENT OWNER

Cohen 1995

Nov 17, 2017EXHIBITPATENT OWNER

Sweetana 1996

Nov 17, 2017EXHIBITPATENT OWNER

Beyea 1996

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2009

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2012

Nov 17, 2017EXHIBITPATENT OWNER

Ellis 2015

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2004

Nov 17, 2017EXHIBITPATENT OWNER

Bellmunt 1991

Nov 17, 2017EXHIBITPATENT OWNER

Chia 2008

Nov 17, 2017EXHIBITPATENT OWNER

Johnston 2013

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2005

Nov 17, 2017EXHIBITPATENT OWNER

Johnston 2004

Nov 17, 2017EXHIBITPATENT OWNER

Pharma Marketletter 2004

Nov 17, 2017EXHIBITPATENT OWNER

Cancer Weekly April 2004

Nov 17, 2017EXHIBITPATENT OWNER

Baumann 1998

Nov 17, 2017EXHIBITPATENT OWNER

Pyrhonen 1994

Nov 17, 2017EXHIBITPATENT OWNER

Stenbygaard 1993

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2014

Nov 17, 2017EXHIBITPATENT OWNER

Barrios 2012

Nov 17, 2017EXHIBITPATENT OWNER

Robertson Eur. J. Cancer 2005

Nov 17, 2017EXHIBITPATENT OWNER

Clinical Practice Guidelines 2003

Nov 17, 2017EXHIBITPATENT OWNER

Vergote 2006

Nov 17, 2017EXHIBITPATENT OWNER

Kuter 2012

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 2006

Nov 17, 2017EXHIBITPATENT OWNER

Remington's Ch. 91

Nov 17, 2017EXHIBITPATENT OWNER

Aulton Ch. 1

Nov 17, 2017EXHIBITPATENT OWNER

Remington's Ch. 75

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 2002

Nov 17, 2017EXHIBITPATENT OWNER

Vidal 1997

Nov 17, 2017EXHIBITPATENT OWNER

Forrest Mylan Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Ansel Ch. 12

Nov 17, 2017EXHIBITPATENT OWNER

Ansel Ch. 13

Nov 17, 2017EXHIBITPATENT OWNER

Ansel Ch. 10

Nov 17, 2017EXHIBITPATENT OWNER

Greenblatt 1978

Nov 17, 2017EXHIBITPATENT OWNER

Lavy 1999

Nov 17, 2017EXHIBITPATENT OWNER

PDR 1999 Estrace

Nov 17, 2017EXHIBITPATENT OWNER

Eagle 1949

Nov 17, 2017EXHIBITPATENT OWNER

Remington's Ch. 9

Nov 17, 2017EXHIBITPATENT OWNER

Bonneterre 1985

Nov 17, 2017EXHIBITPATENT OWNER

Muss 1990

Nov 17, 2017EXHIBITPATENT OWNER

Remington's Ch. 84

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 1994

Nov 17, 2017EXHIBITPATENT OWNER

Groves Ch. 2

Nov 17, 2017EXHIBITPATENT OWNER

Gupta Ch. 1

Nov 17, 2017EXHIBITPATENT OWNER

Baselga 2003

Nov 17, 2017EXHIBITPATENT OWNER

Vidal 1999

Nov 17, 2017EXHIBITPATENT OWNER

ABPI 1999-2000

Nov 17, 2017EXHIBITPATENT OWNER

Remington's Ch. 89

Nov 17, 2017EXHIBITPATENT OWNER

Aulton Ch. 13

Nov 17, 2017EXHIBITPATENT OWNER

Ansel Ch. 7

Nov 17, 2017EXHIBITPATENT OWNER

Aulton Ch. 18

Nov 17, 2017EXHIBITPATENT OWNER

Aulton Ch. 19

Nov 17, 2017EXHIBITPATENT OWNER

Gao 1998

Nov 17, 2017EXHIBITPATENT OWNER

Merck Index 1996

Nov 17, 2017EXHIBITPATENT OWNER

Avis Ch. 4

Nov 17, 2017EXHIBITPATENT OWNER

Aulton Ch. 6

Nov 17, 2017EXHIBITPATENT OWNER

Porras 1999

Nov 17, 2017EXHIBITPATENT OWNER

Ansel Ch. 14

Nov 17, 2017EXHIBITPATENT OWNER

Avis Ch. 2

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar ASCO 2001

Nov 17, 2017EXHIBITPATENT OWNER

Wade 1993

Nov 17, 2017EXHIBITPATENT OWNER

Lundeen 1997

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 2003

Nov 17, 2017EXHIBITPATENT OWNER

Strickley I 1999

Nov 17, 2017EXHIBITPATENT OWNER

Avis Ch. 3

Nov 17, 2017EXHIBITPATENT OWNER

Zuidema 1994

Nov 17, 2017EXHIBITPATENT OWNER

Ballard 1968

Nov 17, 2017EXHIBITPATENT OWNER

Hirano 1981

Nov 17, 2017EXHIBITPATENT OWNER

Litchfield 1961

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 1996

Nov 17, 2017EXHIBITPATENT OWNER

Lifschitz 1999

Nov 17, 2017EXHIBITPATENT OWNER

Chu 1960

Nov 17, 2017EXHIBITPATENT OWNER

Gupta Ch. 17

Nov 17, 2017EXHIBITPATENT OWNER

Huber 1965

Nov 17, 2017EXHIBITPATENT OWNER

Affidavit of Internet Archive

Nov 17, 2017EXHIBITPATENT OWNER

PDR 1999 Arimidex

Nov 17, 2017EXHIBITPATENT OWNER

Skougaard 1966

Nov 17, 2017EXHIBITPATENT OWNER

Levine 1966

Nov 17, 2017EXHIBITPATENT OWNER

Yarinsky 1970

Nov 17, 2017EXHIBITPATENT OWNER

Sawchuk Mylan Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Lachman's 1986

Nov 17, 2017EXHIBITPATENT OWNER

Illum Mylan Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Robertson Mylan Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 1997

Nov 17, 2017EXHIBITPATENT OWNER

Jonat 1996

Nov 17, 2017EXHIBITPATENT OWNER

Dombernowsky 1998

Nov 17, 2017EXHIBITPATENT OWNER

Buzdar 2001

Nov 17, 2017EXHIBITPATENT OWNER

Dowsett Clin. Cancer Res. 1995

Nov 17, 2017EXHIBITPATENT OWNER

Goss 1998

Nov 17, 2017EXHIBITPATENT OWNER

Hoffken 1992

Nov 17, 2017EXHIBITPATENT OWNER

Hortobagyi 1985

Nov 17, 2017EXHIBITPATENT OWNER

Rose 1985

Nov 17, 2017EXHIBITPATENT OWNER

Koyama 1999

Nov 17, 2017EXHIBITPATENT OWNER

Abrams 1990

Nov 17, 2017EXHIBITPATENT OWNER

Jonat 2013

Nov 17, 2017EXHIBITPATENT OWNER

Goss 1986

Nov 17, 2017EXHIBITPATENT OWNER

Stenger 2017

Nov 17, 2017EXHIBITPATENT OWNER

Wright Ch. 4

Nov 17, 2017EXHIBITPATENT OWNER

Huynh 1993

Nov 17, 2017EXHIBITPATENT OWNER

Applied Biopharmaceutics 1999

Nov 17, 2017EXHIBITPATENT OWNER

Abrams 1999

Nov 17, 2017EXHIBITPATENT OWNER

Dowsett 1989

Nov 17, 2017EXHIBITPATENT OWNER

Robertson 2016

Nov 17, 2017EXHIBITPATENT OWNER

Cristofanilli 2016

Nov 17, 2017EXHIBITPATENT OWNER

Strickley II 2000

Nov 17, 2017EXHIBITPATENT OWNER

Martel 1998

Nov 17, 2017EXHIBITPATENT OWNER

Chatterjee 1993

Nov 17, 2017EXHIBITPATENT OWNER

Sibonga 1998

Nov 17, 2017EXHIBITPATENT OWNER

PDR 1999 Inderal LA

Nov 17, 2017EXHIBITPATENT OWNER

InnoPharma Decision

Nov 17, 2017EXHIBITPATENT OWNER

PTAB Order

Nov 17, 2017EXHIBITPATENT OWNER

Dipippo 1997

Nov 17, 2017EXHIBITPATENT OWNER

Al-Matubsi 1998

Nov 17, 2017EXHIBITPATENT OWNER

Oleksowicz Mylan Declaration

Nov 17, 2017EXHIBITPATENT OWNER

Burgess Amneal Declaration

Nov 17, 2017EXHIBITPATENT OWNER

D'Agostino 1990

Nov 17, 2017EXHIBITPATENT OWNER

Rowland Ch. 13

Nov 17, 2017EXHIBITPATENT OWNER

Shapiro 1965

Nov 17, 2017EXHIBITPATENT OWNER

FDA Guidance 1999

Nov 17, 2017EXHIBITPATENT OWNER

InnoPharma Petition

Nov 17, 2017EXHIBITPATENT OWNER

Ex. 3001

Nov 2, 2017EXHIBITBOARD

Order Denying Petitioner's Requests for Authorization to File a Motion to Withdraw the Petition And Motion for Joinder

Nov 2, 2017PAPERBOARD

Patent Owner's Power of Attorney Pursuant to 37 C.F.R. 42.10(b)

Aug 25, 2017PAPERPATENT OWNER

Patent Owner's Mandatory Notices Pursuant to 37 C.F.R. 42.8

Aug 25, 2017PAPERPATENT OWNER

Notice of Accord Filing Date

Aug 17, 2017PAPERBOARD

Howell et al., Pharmacokinetics, pharmacological and anti-tumour effects of the specific anti-oestrogen ICI 182780 in women with advanced breast cancer, 74 BRIT. J. CANCER 300-08 (1996)

Aug 4, 2017EXHIBITPETITIONER

AstraZeneca's Preliminary Response in Mylan Pharms. Inc. v. AstraZeneca AB, Paper No. 10, IPR2016-01325 (P.T.A.B. Oct. 6, 2016)

Aug 4, 2017EXHIBITPETITIONER

Wakeling et al., A Potent Specific Pure Antiestrogen with Clinical Potential, 51 CANCER RESEARCH 3867-3873 (1991)

Aug 4, 2017EXHIBITPETITIONER

Smith, Analysis of Oil-Based Pharmaceuticals, 49 J. AMERICAN OIL CHEMISTS SOCIETY 409-13 (1972)

Aug 4, 2017EXHIBITPETITIONER

Jorgensen, Pharmacokinetic Studies in Volunteers of Intravenous and Oral Cis (Z)-Flupentixol and Intramuscular Cis (Z)-Flupentixol Decanoate in Viscoleo, 18 EUR. J. CLIN. PHARMACOL. 355-60 (1980)

Aug 4, 2017EXHIBITPETITIONER

Fabian, Clinical Pharmacology of Tamoxifen in Patients with Breast Cancer: Correlation with Clinical Data, 48 CANCER 876-82 (1981)

Aug 4, 2017EXHIBITPETITIONER

Copy of Prosecution History for the U.S. Patent No. 8,466,139

Aug 4, 2017EXHIBITPETITIONER

PETITION FOR INTER PARTES REVIEW OF U.S. PATENT NO. 8,329,680 UNDER 35 U.S.C. 311-319 AND 37 C.F.R. 42.100 ET SEQ

Aug 4, 2017PAPERPETITIONER

PETITIONER FRESENIUS KABI'S POWER OF ATTORNEY U.S. PATENT NO. 8,329,680

Aug 4, 2017PAPERPETITIONER

U.S. Patent No. 8,329,680

Aug 4, 2017EXHIBITPETITIONER

Exhibit Reserved

Aug 4, 2017EXHIBITPETITIONER

Exhibit Reserved

Aug 4, 2017EXHIBITPETITIONER

Exhibit Reserved

Aug 4, 2017EXHIBITPETITIONER

Exhibit Reserved

Aug 4, 2017EXHIBITPETITIONER

Copy of Prosecution History for U.S. Patent No. 6,774,122

Aug 4, 2017EXHIBITPETITIONER

McLeskey et al., Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors, 4 CLIN. CANCER RESEARCH 697-711 (1998)

Aug 4, 2017EXHIBITPETITIONER

O'Regan et al., Effects of the Antiestrogens Tamoxifen, Toremifene, and ICI 182,780 on Endometrial Cancer Growth, 90 J. NAT'L CANCER INST. 1552-1558 (1998)

Aug 4, 2017EXHIBITPETITIONER

Order, AstraZeneca Pharms. LP v. Sandoz Inc., No. 14-03547 (D.N.J. July 29, 2015), ECF No. 102

Aug 4, 2017EXHIBITPETITIONER

Institution Decision in Mylan Pharms. Inc. v. AstraZeneca AB, Paper No. 11, IPR2016-01325 (P.T.A.B. Dec. 14, 2016)

Aug 4, 2017EXHIBITPETITIONER

Declaration of Diane Burgess, Ph.D. and Accompanying Exhibits

Aug 4, 2017EXHIBITPETITIONER

Declaration of Richard Bergstrom, Ph.D. and Accompanying Exhibits

Aug 4, 2017EXHIBITPETITIONER

Declaration of Dorraya El-Ashry, Ph.D. and Accompanying Exhibits

Aug 4, 2017EXHIBITPETITIONER

Declaration of Adrian Harris, Ph.D. and Accompanying Exhibits

Aug 4, 2017EXHIBITPETITIONER

U.S. Patent No. 4,659,516

Aug 4, 2017EXHIBITPETITIONER

DeLuca, Formulation of Small Volume Parenterals, PHARMACEUTICAL DOSAGE FORMS: PARENTERAL MEDICATIONS VOLUME 1 (Avis ed., 2d ed. 1992)

Aug 4, 2017EXHIBITPETITIONER

Declaration Under 37 C.F.R. 1.132 of Ronald J. Sawchuk in Application No. 12/285,887

Aug 4, 2017EXHIBITPETITIONER

Declaration Under 37 C.F.R. 1.132 of Paul Richard Gellert in Application No. 10/872,784

Aug 4, 2017EXHIBITPETITIONER

Faslodex Label

Aug 4, 2017EXHIBITPETITIONER

DiPiro, Concepts in Clinical Pharmacokinetics (2010)

Aug 4, 2017EXHIBITPETITIONER

Qiu, Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice (2009)

Aug 4, 2017EXHIBITPETITIONER

Tozer, Introduction to Pharmacokinetics and Pharmacodynamics: The Quantitative Basis of Drug Therapy (2006)

Aug 4, 2017EXHIBITPETITIONER

Caldwell, An Introduction to Drug Disposition: The Basic Principles of Absorption, Distribution, Metabolism, and Excretion, 23 Toxicologic Pathology 102 (1995)

Aug 4, 2017EXHIBITPETITIONER

Wills, "Basic Pharmacodynamic Concepts and Models," Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology (1994)

Aug 4, 2017EXHIBITPETITIONER

Derendorf, Handbook of Pharmacokinetic/Pharmacodynamic Correlation 53 (1995)

Aug 4, 2017EXHIBITPETITIONER

Mager, Scaling Pharmacodynamics from In Vitro and Preclinical Animal Studies to Humans, DRUG METAB. PHARMACOKINET. (2009)

Aug 4, 2017EXHIBITPETITIONER

Colburn, Simultaneous Pharmacokinetic/Pharmacodynamic Modeling, PHARMACODYNAMICS AND DRUG DEVELOPMENT: PERSPECTIVES IN CLINICAL PHARMACOLOGY (1994)

Aug 4, 2017EXHIBITPETITIONER

White, Pharmacokinetic and Pharmacodynamic Considerations in Antimalarial Dose Optimization, 57 ANTIMICROBIAL AGENTS & CHEMOTHERAPY 5802 (2013)

Aug 4, 2017EXHIBITPETITIONER

Nicholson, R.I. et al., Responses To Pure Antiestrogens (ICI 164384, ICI 82780) In Estrogen-Sensitive And -Resistant Experimental And Clinical Breast Cancer, ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol. 61:148-163 (1995)

Aug 4, 2017EXHIBITPETITIONER

Riffkin, Castor Oil as a Vehicle for Parenteral Administration of Steroid Hormones, 53 J. PHARM. SCI. 891-895 (1964)

Aug 4, 2017EXHIBITPETITIONER

Finley, New Drug Being Tested in Breast Cancer Study, SAN ANTONIO EXPRESS-NEWS, Sept. 20, 1997

Aug 4, 2017EXHIBITPETITIONER

Uges, Plasma or Serum in Therapeutic Drug Monitoring and Clinical Toxicology, 10 PHARMACEUTISCH WEEKBLAD SCIENTIFIC EDITION 185-88 (1988)

Aug 4, 2017EXHIBITPETITIONER

Dukes et al., Antiuterotrophic effects of a pure antioestrogen, ICI 182,780: magnetic resonance imaging of the uterus in ovariectomized monkeys, 135 J. ENDOCRINOLOGY 239-247 (1992)

Aug 4, 2017EXHIBITPETITIONER

WO 03/006064

Aug 4, 2017EXHIBITPETITIONER

DeFriend et al., Investigation of a New Pure Antiestrogen (ICI 182780) in Women with Primary Breast Cancer, 54 CANCER RESEARCH 408-414 (1994)

Aug 4, 2017EXHIBITPETITIONER

Osborne et al., Comparison of the Effects of a Pure Steroidal Antiestrogen With Those of Tamoxifen in a Model of Human Breast Cancer, 87 J. NAT'L CANCER INST. 746-750 (1995)

Aug 4, 2017EXHIBITPETITIONER

Alan E. Wakeling & Jean Bowler, ICI 182,780: A New Antioestrogen with Clinical Potential, 43 J. STEROID BIOCHEM. MOLEC. BIOL. 173-177 (1992)

Aug 4, 2017EXHIBITPETITIONER

Howell, A. et al., Clinical Studies With The Specific 'Pure' Antiestrogen ICI 182780, THE BREAST, Vol. 5:192-195 (1996)

Aug 4, 2017EXHIBITPETITIONER

Copy of Prosecution History for U.S. Patent No. 8,329,680 (downloaded from PAIR)

Aug 4, 2017EXHIBITPETITIONER

Robertson, J.F.R. et al., Duration Of Remission To ICI 182,780 Compared To Megestrol Acetate In Tamoxifen Resistant Breast Cancer, THE BREAST, Vol. 6:186-189 (1997)

Aug 4, 2017EXHIBITPETITIONER

Robertson, Fulvestrant Versus Anastrozole for the Treatment of Advanced Breast Carcinoma in Postmenopausal Women: A Prospective Combined Analysis of Two Multicenter Trials, 98 CANCER 229-38 (2003)

Aug 4, 2017EXHIBITPETITIONER

Howell, Response to a Specific Antioestrogen (ICI 182780) in Tamoxifen-Resistant Breast Cancer, 345 LANCET 989-90 (1995)

Aug 4, 2017EXHIBITPETITIONER

Copy of Prosecution History for the U.S. Patent No. 7,456,160

Aug 4, 2017EXHIBITPETITIONER

U.S. Patent No. 5,183,814

Aug 4, 2017EXHIBITPETITIONER

Parczyk, K. et al., Progesterone Receptor Repression by Estrogens in Rat Uterine Epithelial Cells, 63 J. STEROID BIOCHEMISTRY & MOLECULAR BIOLOGY 309 (1997)

Aug 4, 2017EXHIBITPETITIONER

Anderson, Models of New Antioestrogen Action in Vivo: Primary Tumours, 5 THE BREAST 186-91 (1996)

Aug 4, 2017EXHIBITPETITIONER

Buzdar, Update on Endocrine Therapy for Breast Cancer, 4 CLINICAL CANCER RESEARCH 527-34 (1998)

Aug 4, 2017EXHIBITPETITIONER

Howell, New Endocrine Therapies for Breast Cancer, 32A EUR. J. CANCER 576-88 (1996)

Aug 4, 2017EXHIBITPETITIONER

Howell, The Definition of the 'No Change' Category in Patients Treated with Endocrine Therapy and Chemotherapy for Advanced Carcinoma of the Breast, 24 EUR. J. CANCER CLIN. ONCOL. 1567-72 (1988)

Aug 4, 2017EXHIBITPETITIONER

Nicholson, "Pure Antioestrogens in Breast Cancer: Experimental and Clinical Observations," Sex Hormones and Antihormones in Endocrine Dependent Pathology: Basic and Clinical Aspects, Proceedings of an International Symposium, Milano 347-60 (1994)

Aug 4, 2017EXHIBITPETITIONER

Santen, Use of Aromatase Inhibitors in Breast Carcinoma, 6 ENDOCRINE-RELATED CANCER 75-92 (1999)

Aug 4, 2017EXHIBITPETITIONER

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Aug 4, 2017EXHIBITPETITIONER

Howell, Response to a Specific Antioestrogen (ICI 182780) in Tamoxifen-Resistant Breast Cancer, 345 LANCET 29-30 (1995)

Aug 4, 2017EXHIBITPETITIONER

Dukes, Antiuterotrophic Effects of the Pure Antioestrogen ICI 182,780 in Adult Female Monkeys (Macaca nemestrina): Quantitative Magnetic Resonance Imaging, 138 J. ENDOCRINOLOGY 203-09 (1993)

Aug 4, 2017EXHIBITPETITIONER

Wakeling, The Future of New Pure Antioestrogens in Clinical Breast Cancer, 25 BREAST CANCER RESEARCH & TREATMENT 1-9 (1993)

Aug 4, 2017EXHIBITPETITIONER

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Aug 4, 2017EXHIBITPETITIONER

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Aug 4, 2017EXHIBITPETITIONER

Thomas, The Effects of ICI 182,780, a Pure Anti-Oestrogen, on the Hypothalamic-Pituitary-Gonadal Axis and on Endometrial Proliferation in Pre-Menopausal Women, 9 HUMAN REPRODUCTION 1991-96 (1994)

Aug 4, 2017EXHIBITPETITIONER

Freireich, Quantitative Comparison of Toxicity of Anticancer Agents in Mouse, Rat, Hamster, Dog, Monkey, and Man, 50 CANCER CHEMOTHERAPY REPORTS 219-44 (1966)

Aug 4, 2017EXHIBITPETITIONER

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Aug 4, 2017EXHIBITPETITIONER

Clarke, Antiestrogen Resistance in Breast Cancer and the Role of Estrogen Receptor Signaling, 22 ONCOGENE 7316-39 (2003)

Aug 4, 2017EXHIBITPETITIONER

Gusterson, Do we now have a relevant animal model for breast cancer? 1 BREAST CANCER RESEARCH 2-4 (1999)

Aug 4, 2017EXHIBITPETITIONER

Johnston, Changes in Estrogen Receptor, Progesterone Receptor, and pS2 Expression in Tamoxifen-Resistant Human Breast Cancer, 55 CANCER RESEARCH 3331-38 (1995)

Aug 4, 2017EXHIBITPETITIONER

Waynforth, LASA Good Practice Guidelines: Administration of Substances (Rat, Mouse, Guinea Pig, Rabbit) (Oct. 1998)

Aug 4, 2017EXHIBITPETITIONER

Mackey, Tolerability of Intramuscular Injections of Testosterone Ester in Oil Vehicle, 10 HUMAN REPRODUCTION 862-65 (1995)

Aug 4, 2017EXHIBITPETITIONER

Kern, "Role of Angiogenesis in the Transition to Hormone Independence and Acquisition of the Metastatic Phenotype," Endocrinology of Breast Cancer 169-86 (Manni ed., 1999)

Aug 4, 2017EXHIBITPETITIONER

Neubauer, Changes in Tumour Biological Markers during Primary Systemic Chemotherapy (PST), 28 ANTICANCER RESEARCH 1797-804 (2008)

Aug 4, 2017EXHIBITPETITIONER

Spiegel & Noseworthy, Use of Nonaqueous Solvents in Parenteral Products, 52 J. PHARM. SCIS. 917-27 (1963)

Aug 4, 2017EXHIBITPETITIONER

Taucher, Sequential Steroid Hormone Receptor Measurements in Primary Breast Cancer with or without Intervening Primary Chemotherapy, 10 ENDOCRINE-RELATED CANCER 91-98 (2003)

Aug 4, 2017EXHIBITPETITIONER

Turner, Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider, 50 J. AMERICAN ASSOCIATION FOR LABORATORY ANIMAL SCIENCE 600-13 (2011)

Aug 4, 2017EXHIBITPETITIONER

Robertson, J.F.R. et al., (1999)

Aug 4, 2017EXHIBITPETITIONER

Kohler 1992

Aug 4, 2017EXHIBITPETITIONER

Petition for Inter Partes Review in Mylan Pharms. Inc. v. AstraZeneca AB, Paper No. 2, IPR2016-01325 (P.T.A.B. June 29, 2016)

Aug 4, 2017EXHIBITPETITIONER

Handbook of Pharmaceutical Excipients (Wade ed., 2d. ed. 1994)

Aug 4, 2017EXHIBITPETITIONER

FDA's Inactive Ingredient Database (1996)

Aug 4, 2017EXHIBITPETITIONER

Drugs@FDA Glossary of Terms, U.S. FOOD & DRUG ADMINISTRATION (last updated Feb. 2, 2012)

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