Foundation Medicine, Inc. et al. vs Caris MPI, Inc. et al.

Notice of Refund

Request for Refund of Post-Institution Fee

Trial Instituted Document

Notice of Accord Filing Date

Patent Owner's Power of Attorney

Patent Owner's Mandatory Notices

Robert Langreth & Michael Waldholz, New Era of Personalized Medicine Targeting Drugs For Each Unique Genetic Profile, 4 The Oncologist 426 (1999)

Genomics and Personalized Medicine Act of 2006, S. 3822, 109th Cong

Tarceva (erlotinib) Prescribing Information (Nov. 18, 2004)

James Moyer et al., Induction of Apoptosis and Cell Cycle Arrest by CP-358,774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase, 57 Cancer Research 4838 (1997)

ClinicalTrials.gov, Study of TARCEVA (Erlotinib) as Adjuvant Treatment for Locally Advanced Head and Neck Squamous Cell Carcinoma

NCI Drug Dictionary

Henry Q. Xiong & James L. Abbruzzese, Epidermal growth factor receptor-targeted therapy for pancreatic cancer, 29 Seminars in Oncology 31 (2002)

Jane E. Staunton et al., Chemosensitivity prediction by transcriptional profiling, 98 PNAS 10787 (2001)

Atul J. Butte et al., Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks, 97 PNAS 12182 (2000)

Charles Sawyers, Targeted cancer therapy, 432 Nature 294 (2004)

NHGRI Seeks Next Generation of Sequencing Technologies (Oct. 14, 2004)

Jackson B. Gibbs, Anticancer drug targets: growth factors and growth factor signaling, 105 J. Clinical Investigation 9 (2000)

Nida Iqbal & Naveed Iqbal, Imatinib: A Breakthrough of Targeted Therapy in Cancer, Chemotherapy Research & Practice 1 (2014)

Herceptin (trastuzumab) Prescribing Information (Sept. 1998)

S. Scholl, Targeting HER2 in Other Tumor Types, 12 Annals Oncology S81 (2001)

Iressa (gefitinib) Prescribing Information (May 2, 2003)

Erbitux (cetuximab) Prescribing Information (Feb. 12, 2004)

Erbitux (cetuximab) Prescribing Information (Mar. 1, 2006)

Thomas M. Daly et al., Precision Profiling and Components of Variability Analysis for Affymetrix Microarray Assays Run in a Clinical Context, 7 J. Molecular Diagnostics 404 (2005)

Daniel R. Rhodes et al., Oncomine 3.0: Genes, Pathways, and Networks in a Collection of 18,000 Cancer Gene Expression Profiles, 9 Neoplasia 166 (2007)

Alexander Statnikov et al., GEMS: A System for Automated Cancer Diagnosis and Biomarker Discovery from Microarray Gene Expression Data, 74 Int'l J. Med. Informatics 491 (2005)

Justin Lamb et al., The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease, 313 Science 1929 (2006)

Timothy R. Hughes et al., Functional Discovery via a Compendium of Expression Profiles, 102 Cell 109 (2000)

HUGO Gene Nomenclature Committee Symbol Report: EGFR

HUGO Gene Nomenclature Committee Symbol Report: ERBB2

Business Wire, Illumina Launches DASL Assay and Cancer Panel for Gene Expression Profiling of Paraffin Embedded Samples (Jan. 13, 2005)

Marina Bibikova et al Quantitative Gene Expression Profiling in Formalin-Fixed, Paraffin-Embedded Tissues Using Universal Bead Arrays, 165 American J. Pathology 1799 (2004)

Thomas Jarvie, Next generation sequencing technologies, 2 Drug Discovery Today: Technologies 255 (2005)

Daniel R. Rhodes et al., Oncomine: A Cancer Microarray Database and Integrated Data-Mining Platform, 6 Neoplasia 1, 1 (2004)

Daniel R. Rhodes et al., Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression, 25 PNAS 9309 (2004)

H. Parkinson, ArrayExpress - a public repository for microarray gene expression data at the EBI, 33 Nucleic Acids Research D553 (2005)

Jeremy Gollub et al., The Stanford Microarray Database: data access and quality assessment tools, 31 Nucleic Acids Research 94 (2003)

C.J. Zheng et al., TRMP: a database of therapeutically relevant multiple pathways, 20 Bioinformatics 2236 (2004)

X. Chen et al., TTD: Therapeutic Target Database, 30 Nucleic Acids Research 412 (2002)

S. Forbes et al., COSMIC 2005, 94 British J. Cancer 318 (2006)

U.S. Provisional Patent Application No. 60/747,645

Oxford Dictionary of Biochemistry and Molecular Biology (Oxford University Press, 2d ed. 2006)

Xiaojun Zhao et al., Homozygous Deletions and Chromosome Amplifications in Human Lung Carcinomas Revealed by Single Nucleotide Polymorphism Array Analysis, 65 Cancer Research 5561 (2005)

Marina Bibikova et al., Gene Expression Profiles in Formalin-Fixed, Paraffin-Embedded Tissues Obtained with a Novel Assay for Microarray Analysis, 50 Clinical Chemistry 2384 (2004)

Jian-Bing Fan et al., A Versatile Assay for High-Throughput Gene Expression Profiling on Universal Array Matrices, 14 Genome Research 878 (2004)

Jeffrey S. Ross & Geoffrey S. Ginsburg, The Integration of Molecular Diagnostics with Therapeutics: Implications for Drug Development and Pathology Practice, 119 Am. J. Clinical Pathology 26 (2003) ("Ross")

Masuko Katoh & Masaru Katoh, Bioinformatics for Cancer Management in the Post-Genome Era, 5 Technology in Cancer Research & Treatment 169 (2006)

David Stipp, Gene Chip Breakthrough, Fortune Magazine, Mar. 31, 1997, at 56

Jian-Bing Fan et al., BeadArray - based solutions for enabling the promise of pharmacogenomics, 39 BioTechniques 583 (2005)

David S. Wishart et al, DrugBank: a comprehensive resource for in silico drug discovery and exploration, 34 Nucleic Acids Research D668 (2006)

Timothy K. Egan, Monitoring Patients Undergoing Cancer Therapy, 31 Lab. Med. 666 (2000)

HUGO Gene Nomenclature Committee Symbol Report: ESR1

G. William Moore et al., A Prototype Internet Autopsy Database: 1625 Consecutive Fetal and Neonatal Autopsy Facesheets Spanning Twenty Years, 120 Archives Pathology Lab. Med. 782 (1996)

HUGO Gene Nomenclature Committee Symbol Report: CASP8

Phillip G. Febbo & Geoffrey S. Ginsburg, Personalized diagnostic and therapeutic strategies in oncology, 2 Personalized Medicine 97 (2005)

Claudia Dreifus, Researcher Behind the Drug Gleevec, N.Y. Times (Nov. 2, 2009), at D4

Dan L. Longo, Imatinib Changed Everything, 376 New England J. Med. 982 (2017)

Complaint

NIH National Cancer Institute, How Imatinib Transformed Leukemia Treatment and Cancer Research, (updated Apr. 11, 2018)

Federico Cappuzzo et al., Clinical experience with gefitinib: An update, 58 Critical Reviews in Oncology/Hematology 31 (2006)

Yardena Samuels et al., High Frequency of Mutations of the PIK3CA Gene in Human Cancers, 304 Science 554 (2004)

Timothy Ley et al., DNA sequencing of a cytogenetically normal acute myeloid leukemia genome, 456 Nature 66 (2008)

David J. Sugarbaker et al., Transcriptome sequencing of malignant pleural mesothelioma tumors, 105 PNAS 3521 (2008)

Ashish Gautam et al., RRM1-induced metastasis suppression through PTEN-regulated pathways, 22 Oncogene 2135 (2003)

Alberto Bardelli & Victor E. Velculescu, Mutational analysis of gene families in human cancer, 15 Current Opinion in Genetics & Development 5 (2005)

ThermoFisher Scientific, Overview of Immunohistochemistry (IHC)

Hong-Guang Xie & Felix W. Frueh, Pharmacogenomics steps toward personalized medicine, 2 Personalized Medicine 325 (2005)

Andreas Gnirke et al., Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing, 27 Nature Biotechnology 182 (2009)

Andreas Gnirke et al., Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing, 27 Nature Biotechnology 182, Supplementary Figures and Tables (2009)

U.S. Patent Publication No. 2008/0014146 ("Von Hoff")

U.S. Patent No 8,768,629 (the "'629 patent')

HUGO Gene Nomenclature Committee Symbol Report: BRAF

HUGO Gene Nomenclature Committee Symbol Report: RAF1

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Supporting Material (2006)

HUGO Gene Nomenclature Committee Symbol Report: PIK3CA

HUGO Gene Nomenclature Committee Symbol Report: CTNNB1

Degeng Wang, Discrepancy between mRNA and protein abundance: Insight from information retrieval process in computers, 32 Computational Biology & Chemistry 462 (2008)

Gerold Bepler, Pharmacogenomics: A reality or still a promise?, 54 Lung Cancer S3 (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268 (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Table S1 (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Tables S2A and S2B (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Table S3 (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Table S4 (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Table S6 (2006)

Tobias Sjoblom et al., The Consensus Coding Sequences of Human Breast and Colorectal Cancers, 314 Science 268, Table S5 (2006)

Olena Morozova & Marco A. Marra, Applications of next-generation sequencing technologies in functional genomics, 92 Genomics 255 (2008)

Petitioner's Power of Attorney

Gleevec ((imatinib mesylate) Prescribing Information (Jan 2002)

U.S. Provisional Application No. 61/217,289

U.S. Provisional Application No. 61/170,565

KIT Symbol Report - HUGO Gene Nomenclature Committee

KRAS Symbol Report - HUGO Gene Nomenclature Committee

U.S. Provisional Application No. 61/105,335

Butler Affidavit

PCT Publication No. WO 03/017038 (published Feb. 27, 2003) ("Lu")

U.S. Patent Publication No. 2002/0150966 ("Muraca")

Amy L. McDoniels-Silvers et al., Differential Expression of Critical Cellular Genes in Human Lung Adenocarcinomas and Squamous Cell Carcinomas in Comparison to Normal Lung Tissues, 4 Neoplasia 141 (2002)

Illumina Gene Expression Profiling, Technical Bulletin, RNA Profiling with the DASL Assay (2005) ("Illumina")

File History Excerpt

U.S. Patent 9,092,392

Fee Authorization

Declaration of PAUL SPELLMAN, Ph.D.

PETITION FOR INTER PARTES REVIEW OF U.S. PATENT NO. 9,092,392