Associated British Foods plc et al. vs Cornell Research Foundation, Inc. et al.

Other: other court decision

Other: other court decision

Other: Fed Circuit mandate

Order: Granting Motion to Expunge

MOTION TO EXPUNGE CONFIDENTIAL INFORMATION

Order Denying Request for Director Review

Ex. 3100 Director review request

Request for Director Review

Exhibit A

Patent Owner's Updated Mandatory Notice Under 37 C.F.R. 42.8

Patent Owner's Notice of Appeal

ORDER Granting Patent Owner¿¿¿s Motions to Seal 37 C.F.R. ¿¿ 42.54

EX2225 SUBSTITUTE REDACTED version of EX1055

EX2228 SUBSTITUTE REDACTED version of EX1058

EX2229 SUBSTITUTE REDACTED version of EX1059

EX2233 SUBSTITUTE REDACTED version of EX1068

EX2235 SUBSTITUTE REDACTED version of EX1074

EX2236 SUBSTITUTE REDACTED version of EX1076

Patent Owner's Renewed Motion to Seal Pursuant to Protective Order

Patent Owner¿¿¿s Exhibit List 11

EX2226 SUBSTITUTE REDACTED version of EX1056

EX2234 SUBSTITUTE REDACTED version of EX1072

EX2237 SUBSTITUTE REDACTED version of EX1140

EX2238 SUBSTITUTE REDACTED version of EX1144

EX2241 SUBSTITUTE REDACTED version of EX1154

Granting-in-Part Patent Owner's Motions to Seal

Granting Petitioner's Motion to Seal

Granting Motion to Seal

Patent Owner's Fifth Supplemental Mandatory Notice

EX2223 PO Demonstratives_AMENDED REDACTED

Patent Owner's Motion to Seal Pursuant to Protective Order

Patent Owner's Exhibit List 9

EX2224 Final Written Decision_PROPOSED PUBLIC REDACTED

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Patent Owner's Exhibits List 10

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EX2240 Patent Owner's REDACTED version of Petitioners' EX 1153

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EX2242 Patent Owner's REDACTED version of Petitioners' EX 1155

EX2239 Patent Owner's REDACTED version of Petitioners' EX 1152

Petitioners' Motion To Seal Pursuant To Protective Order

EXPUNGED

ORDER Conduct of the Proceeding Regarding Final Written Decisions 35 U.S.C. ¿¿ 318 and 37 C.F.R. ¿¿¿¿ 42.5, 42.73

Patent Owner's Fourth Supplemental Mandatory Notice

Ex 1156 Errata Sheet

Ex 3006

Ex. 3005

Order Granting Joint Request to Withdraw Exhibits

Order Conduct of the Proceeding

Joint Stipulation to Withdraw Exhibits

Hearing Transcript

ORDER Conduct of the Proceeding 37 C.F.R. ¿¿ 42.5

EXPUNGED

REDACTED Petitioners' Demonstratives

P.O.'s Motion to Seal

Oral Hearing Demonstratives

Petitioners' Motion to Seal Pursuant to Protective Order

EXPUNGED

P.O.'s Opposition to Petitioners' Motion to Strike

P.O.'s Reply ISO Omnibus Motion to Exclude

Petitioners' Reply In Support of Motion to Exclude

Petitioners' Motion to Strike

P.O.'s Opposition to Petitioner's Corrected Motion to Exclude

Petitioners' Opposition to Patent Owner's Motion to Exclude

EXPUNGED

Han marked up transcript (Redacted)

Patent Owner's Redacted Sur-Reply

Patent Owner's Exhibit LIst 9

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Lab Notebook of Xingen Lei (March 1995 to November 1998) Public

Dan E. Robertson, Ph.D. Vol. I.mini.Redacted

Dan E. Robertson, Ph.D. Vol. II mini.Redacted

Conduct of the Proceeding Authorizing Motion to Strike Granting Motion to Expunge

Exhibit 3004

Petitioners' Motion to Expunge

Corrected Petitioners' Motion to Exclude

Petitioners' Fourth Set of Objections to Patent Owner's Exhibits

Patent Owner's Motion to Seal

Han marked up transcript

Patent Owner's Omnibus Motion to Exclude

Petitioners' Motion to Exclude Pursuant to 37 C.F.R. 42.64(c)

EXPUNGED

US 7452706 B2 Short

Ex. 2050 US 6855365 Short

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706 Patent - 10.11.2007 ROA

US7432098

US7232677 - 11.23.2004 ROA

US7232677 - 5.19.2004 ROA

20200306_Sigma_Home page

EXPUNGED

EXPUNGED

EXPUNGED

EXPUNGED

Lei Lab NB.Pt1

Lei Lab NB.Pt2

706 Patent - 7.11.2006 Barton Declaration

706 Patent - 9.23.2002 IDS

706 Patent - 10.20.2005 ROA

706 Patent - 7.11.2006 ROA

US7416874 - 6.2006 ROA

US7232677

Benedik marked-up EX1106

US7232677 - 5.126.2005 ROA

20200306_Sigma_Over 22000 Products

20200311_Baeshen 2015, E coli production of proteins

EXPUNGED

20200306_Sigma_30 Products in Pichia

P.O.'s Motion to Seal

EXPUNGED

EXPUNGED

Patent Owner's Sur-Reply

Revised Scheduling Order and Oral Hearing Order

Patent Owner's Request for Oral Hearing

PETITIONERS' REQUEST FOR ORAL ARGUMENT

Petitioners' Reply to POR (Public Redacted Version)

PETITIONERS' CORRECTED MOTION TO SEAL PURSUANT TO PROTECTIVE ORDER

Ex. 1100 - Second Declaration of Dan E. Robertson (Redacted)

Ex. 1101 - Declaration of DeForest McDuff (Redacted)

Ex. 1141 Testimony of Dr. Xin Gen Lei, taken on December 18, 2019 (REDACTED)

Ex. 1147 - Testimony of Yanming Han, taken on January 16, 2020 (REDACTED)

Ex. 1142 - Testimony of Dr. Xin Gen Lei, taken on December 19, 2019 (REDACTED)

Ex. 1143 -Testimony of Dr. Xin Gen Lei, taken on December 20, 2019 (REDACTED)

Ex. 1145 - Testimony of Michael J. Benedik, Ph.D., taken on January 27, 2020 (REDACTED)

Ex. 1146 - Testimony of Michael J. Benedik, Ph.D., taken on January 28, 2020 (REDACTED)

PETITIONERS' UPDATED EXHIBIT LIST (as of March 12, 2020)

Updated Notice of Deposition of Dan E. Robertson, PH. D

Patent Owner's Objections to Evidence Submitted in Petitioners' Reply

Notice of Deposition of Dan E. Robertson, PH.D.

Notice of Deposition of DeForest McDuff, PH.D.

Ex. 1038 - Dassa, et al., "The Acid Phosphatase with Optimum pH of 2.5 of Escherichia coli," J. Biological Chemistry, Vol. 257, No. 12, pp. 6669¿¿¿6676 (1982) ("Dassa 1982")

Ex. 1039 - Greiner, et al., "The Reduction of Phytate in Animal Feedstuffs by an Escherichia coli Phytase"

Ex. 1052 - U.S. Patent No. 7,300,781, "Site-Directed Mutagenesis of Escherichia Coli Phytase"

Ex. 1053 - U.S. Patent No. 6,511,699, "Enzymes with Improved Phytase Activity"

Ex. 1054 - Lei, et al., "Supplemental corn-soybean meal dierts with microbial phytase linearly improves phytate phosphorous utilization by weanling pigs"

Ex. 1045 - Li, et al., "Expression of Areobasidium pullulans xynA in, and Secretion of the Xylanase from, Saccharomyces cerevisae"

Ex. 1046 - Terashima, et al., "The roles of the N-linked carbohydrate chain of rice ¿¿-amylase in thermostability and enzyme kinetics"

Ex. 1050 - Kwon, et al., "Purification and characterization of ¿¿1-antitrypsin secreted by recombinant yeast Saccharomyces diastaticus"

Ex. 1051 - U.S. Patent No. 6,841,370, "Site-Directed Mutagenesis of Escherichia Coli Phytase"

Ex. 1055 - February 7, 1995 Grant Proposal Cornell_IPRs_CRF000001-14

Ex. 1057 - Overexpressing E. coli Phytase Gene in Pichia pastoris dated September 8, 1997 Cornell_IPRs_CRF001075-1078

Ex. 1058 - February 26, 1997 Grant Proposal Cornell_IPRs_CRF000080-95

Ex. 1059 - February 26, 1998 Grant Proposal Cornell_IPRs_CRF000100-117

Ex. 1064 - Database and Depository Printouts Cornell_IPRs_CRF001142-1162

Ex. 1056 - March 1, 1996 Grant Proposal Cornell_IPRs_CRF000024-40

Ex. 1061 - July 22, 1996 Disclosure of Phytase Gene Expression Cornell_IPRs_CRF000132-139

Ex. 1062 - June 30, 1997 Work Plan Cornell_IPRs_CRF001055-1056

Ex. 1065 - Expression of Phytase Gene in Streptomyces lividan A Summary dated January 1, 1996 Cornell_IPRs_CRF001180-1188

Ex. 1072 - Exclusive License Agreement dated September 1, 2001 Huve 0001975-1985

Ex. 1076 - Amendment No. 14 to the Exclusive License Agreement dated April 2, 2014 Huve 0002010-2012

Ex. 1079 - Huvepharma Webpage- OptiPhos

Ex. 1088 - Cregg, et al., "Recent Advances in the Expression of Foreign Genes in Pichia pastoris"

Ex. 1091 - Ferreira, et al., "Techno-economic analysis of the industrial production of a low-cost enzyme using E. coli- the case of recombinant B-glucosidase"

Ex. 1067 - Overexpression of E. coli appA gene in Pichia pastoris, dated September 6, 1997 Cornell_IPRs_CRF001342-1353

Ex. 1068 - Record of Invention: Overexpression of E. coli appA gene in Pichia Pastoris Cornell_IPRs_CRF001354-1355

Ex. 1070 - Rodriguez, et al., "Cloning, Sequencing, and Expression of an Escherichia coli Acid Phosphatase-Phytase Gene (appA2) Isolated from Pig Colon"

Ex. 1074 - Exclusive License Agreement for Patents dated October 13, 2017 Huve 0002000-2008

Ex. 1078 - Huvepharma Webpage- Huvematic

Ex. 1080 - Huvepharma Webpage- OptiPhos Plus

Ex. 1089 - Despreaux, et al., "The dacA gene of Bacillus strearothermophilus coding for D-alanine carboxpeptidase- cloning, structure and expression in Escherichia coli and Pichia pastoris"

Ex. 1098 - Kerovuo, et al., "Isolation, Characterization, Molecular Gene Cloning, and Sequencing of a Novel Phytase from Bacillus subtilis"

Ex. 1093 - Rorer, et al., "Engineering yeast for high level expression"

Ex. 1096 - Jia, et al., "Purification, crystallization and preliminary X-ray analysis of the Escherichia coli phytase"

Ex. 1097 - Kanai, et al., "Recombinant Thermostable Cycloinulo-oligosaccharide Fructanotransferase Produced by Saccharomyces cerevisiae"

Ex. 1099 - Kopp, et al., "The Rocky Road from Fed-Batch to Continuous Processing with E. coli"

EXPUNGED

Ex. 1106 - Sequence Alignment

Ex. 1110 - Tschopp, et al., "Expression of the lacZ gene from two methanol-regulated promoters in Pichia pastoris"

Ex. 1113 - U.S. Patent Application Publication No. US 20190069584, "Thermostable Phytases with High Catalytic Efficacy"

EXPUNGED

Ex. 1103 - Radzio, et al., "Synthesis of biotechnologically relevant heterologous proteins in filamentous fungi"

Ex. 1111 - International Publication No. WO 9727306, "Production and Secretion of Proteins of Bacterial Origin in Filamentous Fungi"

Ex. 1114 - Excerpts from Prosecution History of U.S. Application No. 09715477 leading to U.S. Patent No. 6,841,370

Ex. 1116 - Outchkourov, et al., "Phytase for Feed Applications"

Ex. 1118 - AgriHealth webpage regarding OptiPhos Plus

Ex. 1119 - AllAboutFeed, "Ronozyme HiPhos from DSM Receives EU approval"

Ex. 1120 - AllAboutFeed, "AB Vista- Quantum Blue launched in South Africa"

Ex. 1121 - Associated British Foods plc - About us - Our Group - Overview

Ex. 1115 - Tsuru, et al, "Studies on Bacterial Protease, PartXIV. Zinc as an Essential Metal Component of Neutral Protease of Bacillus subtilis var. amylosacchariticus"

Ex. 1122 - Steele, "Cornell inventors get lots of help with patents - but not every idea leads to pot of gold"

Ex. 1124 - Phytases - Feed enzymes - Products - DSM webpage regarding Ronozyme phytases - release more phospohorus

Ex. 1125 - Du Pont Brochure: Axtra PHY

Ex. 1127 - Axtra PHY product launch - Danisco Animal Nutrition (2014)

Ex. 1129 - DSM-Novozymes Phytase to Hit European Market this Autumn (2009)

Ex. 1132 - Novozymes webpage regarding Ronozyme

Ex. 1136 - Zyla, "Phytase applications in poultry feeding- Selected issues"

Ex. 1126 - Du Pont Brochure- 25 plus Years of Feed Enzyme Innovation from Danisco Animal Nutrition (2014)

Ex. 1128 - Axtra PHY: The fast-acting phytase for poultry and swine - Danisco Animal Nutrition

Ex. 1130 - Goncalves, et al., "Fact sheets - comparing phytase sources for pigs and effects of superdosing phytase of growth performance of nursery and finishing pigs"

Ex. 1131 - FEEDAP et al., "Safety and efficacy of Natuphos E (6-phytase) as a feed additive for avian and porcine species"

Ex. 1134 - PigProgress, ¿¿¿AB Vista launches Finase EC in the EU¿¿¿

Ex. 1135 - PoultryWorld, "Quantum Blue phytase launched at IPR"

Ex. 1139 - Towers, "AB Vista¿¿¿s Quantum Blue: Revolutionary New Phytase," The Poultry Site, (2014)

Ex. 1140 - Testimony of Spas Bojidarov Petkov taken on February 7, 2020

Ex. 1142 - Testimony of Dr. Xin Gen Lei, taken on December 19, 2019

Ex. 1143 - Testimony of Dr. Xin Gen Lei, taken on December 20, 2019

Ex. 1144 - Testimony of Glen Michael Wilkinson, taken on January 22, 2020

Ex. 1146 - Testimony of Michael J. Benedik, Ph.D., taken on January 28, 2020

Ex. 1147 - Testimony of Yanming Han, taken on January 16, 2020

Ex. 1149 - Solovicova, et al., "High-Yield Production of Saccharomycopsis..."

Ex. 1137 - Syngenta AG, Securities and Exchange Commission Form 20-F for fiscal year ended: December 31, 2004

Ex. 1138 - Syngenta AG, Securities and Exchange Commission Form 20-F for fiscal year ended: December 31, 2007

Ex. 1141 - Testimony of Dr. Xin Gen Lei, taken on December 18, 2019

Ex. 1145 - Testimony of Michael J. Benedik, Ph.D., taken on January 27, 2020

Ex. 1148 - Simpson, et al, "Prevalence and predictors of work related respiratory symptoms in workers exposed to organic dusts"

EXPUNGED

EXPUNGED

Ex. 1152 - Excel spreadsheet of thermostability testing data commissioned by Huvepharma in September 2016 CRF EX2189

Ex. 1154 - Excel spreadsheet of thermostability testing data commissioned by Huvepharma in March 2017 CRF EX2191

Ex. 1153 - Laboratory report and methodology for thermostability test commissioned by Huvepharma in September 2016 CRF EX2190

Ex. 1155 - FDA Product Submissions Corrected CRF EX2112 [PART 1 of 2]

Ex. 1155 - FDA Product Submissions Corrected CRF EX2112 [PART 2 of 2]

Petitioner's Updated Exhibit List (as of February 26, 2020)

EXPUNGED

Petitioners' Motion to Seal Pursuant to Protective Order

Patent Owner Power of Attorney (Baker Botts)

Patent Owner Third Supplemental Mandatory Notice

Joint Stipulation Extending Due Dates 2-3

Notice of Deposition of Michael J. Benedik, Ph.D.

Notice of Deposition of Spas Petkov

Notice of Deposition of Glen Wilkinson

Notice of Deposition of Yanming Han, Ph.D.

Patent Owner Exhibit List 8 (PUBLIC REDACTED VERSION)

CFR 2067 Spreadsheet on Thermostability dated Jan 30, 1997 (PUBLIC REDACTED VERSION)

Patent Owner Response (PUBLIC REDACTED VERSION)

CFR 2065 Spreadsheet on Thermostability dated July 17, 1996 (PUBLIC REDACTED VERSION)

CFR 2066 Work Summary dated Feb 23, 1997 (PUBLIC REDACTED VERSION)

CFR 2068 Work Summary dated May 15, 1997 (PUBLIC REDACTED VERSION)

CFR 2069 Part 1 of 2 Han Laboratory Notebook (PUBLIC REDACTED VERSION)

CFR 2069 Part 2 of 2 Han Laboratory Notebook (PUBLIC REDACTED VERSION)

CFR 2070 Part 2 of 6 Lab Documents Compilation (PUBLIC REDACTED VERSION)

CFR 2070 Part 4 of 6 Lab Documents Compilation (PUBLIC REDACTED VERSION)

CFR 2070 Part 5 of 6 Lab Documents Compilation (PUBLIC REDACTED VERSION)

CFR 2070 Part 1 of 6 Lab Documents Compilation (PUBLIC REDACTED VERSION)

CFR 2070 Part 3 of 6 Lab Documents Compilation (PUBLIC REDACTED VERSION)

CFR 2070 Part 6 of 6 Lab Documents Compilation (PUBLIC REDACTED VERSION)

CRF 2082 Part 1 of 2 Stahl Laboratory Notebook (PUBLIC REDACTED VERSION)

CRF 2082 Part 2 of 2 Stahl Laboratory Notebook (PUBLIC REDACTED VERSION)

CRF 2083 Stahl Laboratory Notebook (PUBLIC REDACTED VERSION)

CRF 2071 Spreadsheet Assay dated July 7, 1997 (PUBLIC REDACTED VERSION)

CRF 2072 Beckman Printout dated July 7, 1997 (PUBLIC REDACTED VERSION)

CRF 2073 Spreadsheet - Heat dated Aug 20, 1997 (PUBLIC REDACTED VERSION)

CRF 2074 Beckman Printout dated Aug 20, 1997 (PUBLIC REDACTED VERSION)

CRF 2078 ABF_IPR002002-38 Letter from AB Enzymes (PUBLIC REDACTED VERSION)

CRF 2086 Benedik Declaration (PUBLIC REDACTED VERSION)

CRF 2102 Wilkinson Declaration (PUBLIC REDACTED VERSION)

CRF 2111 Claim Chart for USP 7,313,063 (IPR580) (PUBLIC REDACTED VERSION)

CRF 2113 ABF_IPR000004-40 Claim Chart for USP 8,993,300 Quantum Blue (PUBLIC REDACTED VERSION)

CRF 2112 EcoPhos FDA Summary (PUBLIC REDACTED VERSION)

CRF 2117 ABF_IPR000095-107 Claim Chart for USP 7,829,318 Quantum Phytase (PUBLIC REDACTED VERSION)

CRF 2118 ABF_IPR000108-117 Claim Chart for USP 8,455,232 Quantum Phytase (PUBLIC REDACTED VERSION)

CRF 2120 Part 2 of 2 ABF_IPR001190-1998 Jan 2014 Quantum Blue Dossier (PUBLIC REDACTED VERSION)

CRF 2121 ABF_IPR002361-2420 ABV Quantum Phytase (PUBLIC REDACTED VERSION)

CRF 2145 ABF_IPR002421-2641 Quantum Blue Technical Presentation (PUBLIC REDACTED VERSION)

CRF 2153 ABF_IPR000118-262 Quantum Phytase EFSA App_CD (PUBLIC REDACTED VERSION)

CRF 2154 ABF_IPR000263-650 Quantum Phytase EFSA App (PUBLIC REDACTED VERSION)

CRF 2156 ABF_IPR002039 Pekka Kekki To Whom It May Concern (PUBLIC REDACTED VERSION)

CRF 2158 ABF_IPR002041-2044 Flow Chart (PUBLIC REDACTED VERSION)

CRF 2160 ABF_IPR002047 Email dated Apr 23, 2015 (PUBLIC REDACTED VERSION)

CRF 2162 ABF_IPR002049-2269 Aug 2015 - ABV Training (PUBLIC REDACTED VERSION)

CRF 2164 ABF_IPR002271-2295 Sept 2011 Quantum Blue Dossier (PUBLIC REDACTED VERSION)

CRF 2114 ABF_IPR000041-55 Claim Chart for USP 6,451,572 Quantum Phytase (PUBLIC REDACTED VERSION)

CRF 2115 ABF_IPR000056-79 Claim Chart for USP 7,026,150 Quantum Phytase (PUBLIC REDACTED VERSION)

CRF 2116 ABF_IPR000080-94 Claim Chart for USP 7,312,063 Quantum Phytase (PUBLIC REDACTED VERSION)

CRF 2119 ABF_IPR000768-1189 Quantum Phytase FDA (PUBLIC REDACTED VERSION)

CRF 2120 Part 1 of 2 ABF_IPR001190-1998 Jan 2014 Quantum Blue Dossier (PUBLIC REDACTED VERSION)

CRF 2122 ABF_IPR002674-2714 Dec 14, 2015 ABE-ABV Quarterly Review (PUBLIC REDACTED VERSION)

CRF 2123 ABF_IPR003475 ABV Quantum Sales (PUBLIC REDACTED VERSION)

CRF 2126 Sequence Alignment of Proprietary Sequence and Dassa (PUBLIC REDACTED VERSION)

CRF 2147 Petkov Declaration (PUBLIC REDACTED VERSION)

CRF 2152 ABF_IPR000001-3 Huvepharma Final Infringement Contentions (PUBLIC REDACTED VERSION)

CRF 2155 ABF_IPR001999-2001 Email dated Jan 18, 2013 App (PUBLIC REDACTED VERSION)

CRF 2157 ABF_IPR002040 To Whom It May Concern (PUBLIC REDACTED VERSION)

CRF 2159 ABF_IPR002045-2046 Email dated Mar 18, 2014 (PUBLIC REDACTED VERSION)

CRF 2161 ABF_IPR002048 Email dated Feb 11, 2015 (PUBLIC REDACTED VERSION)

CRF 2163 ABF_IPR002270 Sept 11, 2015 Quantum Blue (PUBLIC REDACTED VERSION)

CRF 2166 ABF_IPR002333-2337 Email dated Feb 10, 2017 (PUBLIC REDACTED VERSION)

CRF 2167 ABF_IPR002338-2355 May 5, 2015 ABE-ABV Operations Review (PUBLIC REDACTED VERSION)

CRF 2165 ABF_IPR002296-2332 Quantum Blue AG GMO Evaluation Declaration (PUBLIC REDACTED VERSION)

CRF 2168 ABF_IPR002356.001-2356.015 Spreadsheet Customer Names (PUBLIC REDACTED VERSION)

CRF 2175 ABF_IPR002716-2738 Email from Feedinfo News Service to Dieter Suida (PUBLIC REDACTED VERSION)

CRF 2177 ABF_IPR002742-3281 Patent Search Results (PUBLIC REDACTED VERSION)

CORRECTED Patent Owner Motion to Seal

CRF 2169 ABF_IPR002357.001-2357.015 Spreadsheet Supplier Manufacturing (PUBLIC REDACTED VERSION)

CRF 2170 ABF_IPR002358-2360 Email dated Sept 27, 2013 (PUBLIC REDACTED VERSION)

CRF 2171 ABF_IPR002642 Email dated Oct 29, 2013 (PUBLIC REDACTED VERSION)

CRF 2172 ABF_IPR002643-2650 Review (PUBLIC REDACTED VERSION)

CRF 2173 ABF_IPR002651-2673 Leading by Example (PUBLIC REDACTED VERSION)

CRF 2174 ABF_IPR002715 Email dated Dec 17, 2015 (PUBLIC REDACTED VERSION)

CRF 2176 ABF_IPR002739-2741 Email dated Feb 20, 2017 (PUBLIC REDACTED VERSION)

CRF 2178 ABF_IPR003311-3313 2013 EFSA Scientific Opinion (PUBLIC REDACTED VERSION)

CRF 2179 ABF_IPR003314-3317 Creative Proteomics Analysis Report (PUBLIC REDACTED VERSION)

CRF 2182 ABF_IPR003927-3934 ABVista Quote (PUBLIC REDACTED VERSION)

CRF 2183 ABF_IPR003935-3937 Spreadsheet Protein ID Intensities (PUBLIC REDACTED VERSION)

CRF 2184 ABF_IPR003938-3972 Spreadsheet Sequences (PUBLIC REDACTED VERSION)

CRF 2185 ABF_IPR003973-4011 Spreadsheet Protein IDs Peptide (PUBLIC REDACTED VERSION)

CRF 2188 Huvepharma EFSA Submission (PUBLIC REDACTED VERSION)

Petitioners' Deposition Notice of Xingen Lei, Ph.D.

Petitioners' Third Set of Objections to Patent Owner's Exhibits

EXPUNGED

Patent Owner Notice of Filing Transcript of November 5, 2019 Conference Call

CRF 2027 Owh Declaration

CRF 2049 Flamm 1991

CRF 2072 Beckman Printout 1997-07-07 (FILED UNDER SEAL)

CRF 2079 ABF_IPR003282 Intl Poultry (FILED UNDER SEAL)

CRF 2028 Second Merkel Declaration

CRF 2051 Sandercock 1996

CRF 2054 Wang 1993

CRF 2056 US7977080 Gramatikova

CRF 2060 Curry 1988

CRF 2064 Han Declaration (FILED UNDER SEAL)

CRF 2065 Spreadsheet thermostability 1996-07-17 (FILED UNDER SEAL)

CRF 2066 Work Summary 1997-02-23 (FILED UNDER SEAL)

CRF 2067 Spreadsheet thermostability 1997-01-30 (FILED UNDER SEAL)

CRF 2068 Work Summary 1997-05-15 (FILED UNDER SEAL)

CRF 2069 Part1of2 Han Lab NB (FILED UNDER SEAL)

CRF 2069 Part2of2 Han Lab NB (FILED UNDER SEAL)

CRF 2070 Part1of6 Lab Docs Compilation (FILED UNDER SEAL)

CRF 2070 Part3of6 Lab Docs Compilation (FILED UNDER SEAL)

CRF 2070 Part4of6 Lab Docs Compilation (FILED UNDER SEAL)

CRF 2070 Part5of6 Lab Docs Compilation (FILED UNDER SEAL)

CRF 2070 Part6of6 Lab Docs Compilation (FILED UNDER SEAL)

CRF 2071 Spreadsheet assay 1997-07-07 (FILED UNDER SEAL)

CRF 2073 Spreadsheet heat 1997-08-20 (FILED UNDER SEAL)

CRF 2074 Beckman Printout 1997-08-20 (FILED UNDER SEAL)

CRF 2075 Third Merkel Declaration

CRF 2076 pPICZalpha ABC Catalog

CRF 2077 Screenshot of retrieval of pPICZalpha ABC Catalog

CRF 2078 ABF_IPR002002 2013-01-25 Letter (FILED UNDER SEAL)

CRF 2080 Second Lei Declaration (FILED UNDER SEAL)

CRF 2081 Stahl Declaration (FILED UNDER SEAL)

CRF 2082 Part1of2 Stahl Lab NB (FILED UNDER SEAL)

CRF 2082 Part2of2 Stahl Lab NB (FILED UNDER SEAL)

CRF 2083 Stahl Lab NB (FILED UNDER SEAL)

CRF 2084 Robertson Deposition Transcript 2019-10-02

CRF 2085 Robertson Deposition Transcript 2019-10-03

CRF 2087 Benedik CV

CRF 2091 Alberts Molecular Biology 1989

CRF 2100 Cheng JY35 x Dassa

CRF 2104 Kim & Lei Enhancing 2008

CRF 2110 EC Webb Enzyme 1992

CRF 2113 ABF_IPR000004 Claim Chart_300 QuantumBlue (FILED UNDER SEAL)

CRF 2114 ABF_IPR000041 Claim Chart_572 QuantumPhytase (FILED UNDER SEAL)

CRF 2088 Clark 2013

CRF 2089 Lis Protein 1993

CRF 2090 Voet Biochemistry 1995

CRF 2092 Tanner Protein 1987

CRF 2093 Opdenakker Concepts 1993

CRF 2094 Kobata Structures 1992

CRF 2095 VandenSteen Concepts 1998

CRF 2096 Ostanin Overexpression 1992

CRF 2097 Kretz x pAPPA1

CRF 2098 Cheng JY35 x Kretz

CRF 2099 Olsen MAC and H1 x Kretz

CRF 2101 ATCC 87441

CRF 2102 Wilkinson Declaration (FILED UNDER SEAL)

CRF 2103 US 6974690 Lei

CRF 2105 Kim Assembly 2008

CRF 2106 Lee Expression 2005

CRF 2107 Messner Bacterial 1997

CRF 2108 Bardwell Pathway 1993

CRF 2109 Lim Crystal 2000

CRF 2111 Claim Chart_063 EcoPhos (IPR580) (FILED UNDER SEAL)

CRF 2112 EcoPhos FDA Summary (FILED UNDER SEAL)

CRF 2115 ABF_IPR000056 Claim Chart_150 QuantumPhytase (FILED UNDER SEAL)

CRF 2116 ABF_IPR000080 Claim Chart_063 QuantumPhytase (FILED UNDER SEAL)

CRF 2117 ABF_IPR000095 Claim Chart_318 QuantumPhytase (FILED UNDER SEAL)

CRF 2118 ABF_IPR000108 Claim Chart_232 QuantumPhytase (FILED UNDER SEAL)

CRF 2119 ABF_IPR000768 QuantumPhytase FDA (FILED UNDER SEAL)

CRF 2120 Part1of2 ABF_IPR001190 2014-01 QuantumBlue Dossier (FILED UNDER SEAL)

CRF 2122 ABF_IPR002674 2015-12-14 ABE-ABV Quarterly Review (FILED UNDER SEAL)

CRF 2138 ABF_IPR003416_2008 EFSA QuantumPhytase (FILED UNDER SEAL)

CRF 2144 ABF_IPR003358 ABV QuantumBlue Update (FILED UNDER SEAL)

CRF 2149 OptiPhos Thermostability Data

CRF 2151 Wyss Comparison 1998

CRF 2154 ABF_IPR000263 QuantumPhytase EFSA App (FILED UNDER SEAL)

CRF 2120 Part2of2 ABF_IPR001190 2014-01 QuantumBlue Dossier (FILED UNDER SEAL)

CRF 2121 ABF_IPR002361 ABV QuantumPhytase (FILED UNDER SEAL)

CRF 2123 ABF_IPR003475 ABV Quantum Sales (FILED UNDER SEAL)

CRF 2124 Annotated Fig2 Dassa

CRF 2125 Annotated Figs1A-1B Kretz

CRF 2126 AppA2C x Dassa

CRF 2127 Olsen MAC and H1 x Dassa

CRF 2128 Panek Effects 2013

CRF 2129 Makrides Strategies 1996

CRF 2130 Lall Comparison 1989

CRF 2131 Rosano Recombinant 2014

CRF 2132 Borriss Molecular 1988

CRF 2133 Borriss Hybrid 1989

CRF 2134 Borriss Structure 1990

CRF 2135 Ullah Disulfide 1996

CRF 2136 ABF_IPR003284 2012-04-17 ABE PPT (FILED UNDER SEAL)

CRF 2137 ABF_IPR003328 2012-12-13 ABE PPT (FILED UNDER SEAL)

CRF 2139 ABF_IPR003402 QuantumBlue10G photos (FILED UNDER SEAL)

CRF 2140 ABF_IPR003407 QuantumBlue5G photos (FILED UNDER SEAL)

CRF 2141 ABF_IPR003400 QuantumBlue Revolution (FILED UNDER SEAL)

CRF 2142 ABF_IPR003410 QuantumBlue Stability (FILED UNDER SEAL)

CRF 2143 ABF_IPR003411 QuantumBlue Productivity (FILED UNDER SEAL)

CRF 2145 ABF_IPR002421 QuantumBlue Tech (FILED UNDER SEAL)

CRF 2146 ABF_IPR003443 DED18-129 Amended Answer (FILED UNDER SEAL)

CRF 2147 Petkov Declaration (FILED UNDER SEAL)

CRF 2148 Comparative Thermostability Data

CRF 2150 Second Sheets Declaration

CRF 2152 ABF_IPR000001 Huve Final Infringement Contentions (FILED UNDER SEAL)

CRF 2153 ABF_IPR000118 QuantumPhytase EFSA App_CD (FILED UNDER SEAL)

CRF 2155 ABF_IPR001999 2013-01-18 Email (FILED UNDER SEAL)

CRF 2156 ABF_IPR002039 2016-01-20 Roal Oy (FILED UNDER SEAL)

CRF 2157 ABF_IPR002040 Roal Oy distributors (FILED UNDER SEAL)

CRF 2158 ABF_IPR002041 Roal Flow Chart (FILED UNDER SEAL)

CRF 2159 ABF_IPR002045 2014-03-18 Email (FILED UNDER SEAL)

CRF 2160 ABF_IPR002047 2015-04-23 Email (FILED UNDER SEAL)

CRF 2161 ABF_IPR002048 2015-02-11 Email (FILED UNDER SEAL)

CRF 2162 ABF_IPR002049 2015-08 ABV Training (FILED UNDER SEAL)

CRF 2163 ABF_IPR002270 2015-09-11 QuantumBlue (FILED UNDER SEAL)

CRF 2167 ABF_IPR002338 2015-05-05 ABE-ABV Ops (FILED UNDER SEAL)

CRF 2168 ABF_IPR002356.001 Spreadsheet Customer Names (FILED UNDER SEAL)

CRF 2169 ABF_IPR002357.001 Spreadhseet Supplier Mfg (FILED UNDER SEAL)

CRF 2164 ABF_IPR002271 2011-09 QuantumBlue dossier (FILED UNDER SEAL)

CRF 2165 ABF_IPR002296 QuantumBlue Ag GMO Eval (FILED UNDER SEAL)

CRF 2166 ABF_IPR002333 2017-02-10 Email (FILED UNDER SEAL)

CRF 2170 ABF_IPR002358 2013-09-27 Email (FILED UNDER SEAL)

CRF 2171 ABF_IPR002642 2013-10-29 Email (FILED UNDER SEAL)

CRF 2172 ABF_IPR002643 Optiphos Patent Review (FILED UNDER SEAL)

CRF 2173 ABF_IPR002651 QuantumBlue HiPhos (FILED UNDER SEAL)

CRF 2174 ABF_IPR002715 2015-12-17 Email (FILED UNDER SEAL)

CRF 2175 ABF_IPR002716 2013-09-19 Email (FILED UNDER SEAL)

CRF 2176 ABF_IPR002739 2017-02-20 Email (FILED UNDER SEAL)

CRF 2177 ABF_IPR002742 Patent Search Results (FILED UNDER SEAL)

CRF 2178 ABF_IPR003311 2013 EFSA QuantumBlue (FILED UNDER SEAL)

CRF 2179 ABF_IPR003314 2017-12-01 CP AnalysisReport (FILED UNDER SEAL)

CRF 2180 ABF_IPR003318 2013 EFSA QuantumBlue (FILED UNDER SEAL)

CRF 2181 ABF_IPR003476 Lei Phytase 2013 (FILED UNDER SEAL)

CRF 2182 ABF_IPR003927 2011-08-19 ABV Tyson Quote (FILED UNDER SEAL)

CRF 2183 ABF_IPR003935 Spreadsheet Protein ID Intensities (FILED UNDER SEAL)

CRF 2184 ABF_IPR003938 Spreadsheet Sequences (FILED UNDER SEAL)

CRF 2185 ABF_IPR003973 Spreadsheet Protein IDs Peptides (FILED UNDER SEAL)

CRF 2186 2019-11-05 Conference Call Transcript

CRF 2187 Historical Phytase Market Share Data

CRF 2188 Huve EFSA Section II (FILED UNDER SEAL)

CRF 2070 Part2of6 Lab Docs Compilation (FILED UNDER SEAL)

Patent Owner Motion to Seal

CRF 2086 Benedik Declaration (FILED UNDER SEAL)

Patent Owner Response (FILED UNDER SEAL)

Order - Granting Joint Motion to Enter Jointly Proposed Protective Order - 35 USC 326(a)(7); 37 CFR 42.54

Joint Motion to Enter Jointly Proposed Protective Order

Order Conduct of the Proceeding

Ex. 1044 - Redlined Proposed Protective Order

Petitioners Updated Exhibit List (as of October 30, 2019)

Jointly Proposed Protective Order

Ex. 1043 - Proposed Protective Order

ERRATA

Second Joint Stipulation Extending Due Dates 1-3

Granting Patent Owner's Motion for Additional Discovery 37 C.F.R. sec. 42.51(b)(2)

Petitioners' Opposition to Patent Owner's Motion for Additional Discovery

Petitioners' Motion to Submit Supplemental Information 37 C.F.R. sec. 42.123(a)

Exhibit 3003

Petitioners' Second Set Of Objections To Patent Owner's Exhibits

Patent Owner Notice of Deposition of Dan E. Robertson, Ph.D.

Patent Owner¿¿¿s Motion for Limited Discovery from Petitioners Regarding Objective Evidence of Non-obviousness

Patent Owner¿¿¿s Exhibit List 6

CX 2033 ABF Annual Report 2012 excerpt

CX 2031 Sheets Declaration

CX 2032 AllAboutFeed 2012

CX 2034 abvista Positive Sales Growth 2015

CX 2036 ABF Annual Report 2014 excerpt

CX 2037 Huvepharma Claim Chart_30

CX 2038 Huvepharma Claim Chart_572

CX 2035 AnimalPharm AB Vista Climbs 2018

CX 2039 Huvepharma Claim Chart_150

CX 2041 Huvepharma Claim Chart_318

CX 2042 Huvepharma Claim Chart_232

CX 2043 Quantum Blue 10G Photos

CX 2047 Quantum Blue Revolution Brochure

CX 2040 Huvepharma Claim Chart_063

CX 2044 Quantum Blue Productivity Brochure

CX 2045 EFSA Quantum 2008

CX 2046 Hadden

ORDER Conduct of the Proceeding Granting Patent Owner Authorization to File Motion for Additional Discovery 37 C.F.R. ¿¿ 42.5; 37 C.F.R. ¿¿ 42.20(b)

Joint Stipulation Extending Due Dates 1-3

Granting Patent Owner's Motion for Pro Hac Vice Admission of Andrew P. Zappia

Patent Owner's Exhibit List 5

Patent Owner's Notice of Filing Transcript of September 5, 2019 Conference Call

CX 2030 Transcript Sept 5 2019 Conference Call

Petitioners Unopposed Motion to Submit Supplemental Information

Ex 1041 - U.S. Provisional Application No. 60/019,735, which is a priority application for the Cheng reference (Ex. 1004)

Ex 1042 - U.S. Patent No. 5,939,303; issued from Application No. 08/744,779, which is a priority application for the Cheng reference (Ex. 1004)

Petitioners Updated Exhibit List as of August 30, 2019

Patent Owner's Motion for Pro Hac Vice Admission of Andrew P. Zappia

CX 2029 Zappia Declaration ISO PHV

Patent Owner's Exhibit List 4

Ex. 3001

Patent Owner's Objections to Evidence Submitted with Petition

Petitioners' First Set Of Objections To Patent Owner's Exhibits

Decision Institution of Inter Partes Review

Scheduling Order

Petitioners Updated Exhibit List (as of July 12, 2019)

Ex. 1036 - Memorandum Opinion

Ex. 1037 - Claim Construction Order

Patent Owner's Authorized Sur-Reply_IPR580

Petitioners' Authorized Reply to Patent Owner's Preliminary Response

Patent Owner's Notice of Filing Transcript of May 29 2019 Conference Call_IPR580

CX 2026 Transcript May 29 2019 Conference Call_IPR580

Patent Owner's Exhibit List 2_IPR580

Order Granting Petitioners' Motion to Withdraw and Substitute Counsel

Order Granting Petitioners' Motions for Pro Hac ViceAdmission of Kurt A. Mathas and Claire A. Fundakowski

Order - 37 C.F.R. 42.5

Petitioners Motion for Pro Hac Vice Admission of Kurt A. Mathas

Ex. 1034 - Declaration of Kurt A. Mathas In Support of Motion for Pro Hac Vice Admission

Ex. 1035 - Declaration of Claire A. Fundakowski In Support of Motion for Pro Hac Vice Admission

Petitioners Motion for Pro Hac Vice Admission of Claire A. Fundakowski

Petitioners Updated Exhibit List (as of May 16, 2019)

Petitioners Motion to Withdraw and Substitute Counsel

Petitioners Supplemental Mandatory Notice

Petitioners Updated Power of Attorney

Patent Owner's Preliminary Response

Patent Owner's Exhibit List 1

CX 2003 Lei Memo 1 1996-07-22_IPR580

CX 2004 D-1986 IDF_IPR580

Declaration of Richard S. Cahoon, Ph.D.

CX 2002 Cahoon CV_IPR580

CX 2007 Lei Memo 1 Manuscript_IPR580

CX 2009 Lei Memo 2 Manuscripts_IPR580

CX 2013 D-2110 IDF_IPR580

CX 2005 D-1986 RoI_IPR580

CX 2006 Lei Memo 1 Summary_IPR580

CX 2008 Lei Memo 2 1997-04-17_IPR580

CX 2010 Reynolds Memo D-2109 CRF_IPR580

CX 2011 Reynolds Memo D-2110 CRF_IPR580

CX 2012 D-2109 IDF_IPR580

CX 2015 Lei CV_IPR580

CX 2014 Lei Declaration_IPR580

CX 2016 Beckman_IPR580

CX 2018 NBRC List of Yeasts_IPR580

CX 2020 Reynolds Memo D-2110 Lei_IPR580

CX 2023 pYES2 Fax from Invitrogen_IPR580

CX 2017 NBRC List of Filamentous Fungi_IPR580

CX 2019 Reynolds Memo D-2109 Lei_IPR580

CX 2021 Merkel Declaration_IPR580

CX 2024 Lehninger_IPR580

CX 2025 Rose and Broach 1990_IPR580

Patent Owner's Second Supplemental Mandatory Notice Under 37 CFR 42.8

Patent Owner's Power of Attorney Pursuant to 37 C.F.R. 42.10(b) for Inter Partes Review

Patent Owner's Supplemental Mandatory Notice Under 37 C.F.R. 42.8

Patent Owner's Mandatory Notice under 37 CFR 42.8

Notice of Accord Filing Date

Ex. 1004 - U.S. Patent No. 5,985,605 to Cheng, et al.

Ex. 1003 - U.S. Patent No. 5,876,997 to Kretz

Ex. 1006 - Dassa, et al., "The Complete Nucleotide Sequence of the Escherichia coli Gene appA Reveals Significant Homology between pH 2.5 Acid Phosphatase and Glucose-1-Phosphatase"

Ex. 1008 - U.S. Patent No. 5,436,156 to Van Gorcom, et al.

Ex. 1010 - Dassa, et al., "The Acid Phosphatase with Optimum pH of 2.5 of Escherichia coli"

Ex. 1012 - Greiner, et al., "The Reduction of Phytate in Animal Feedstuffs by an Escherichia coli Phytase"

Ex. 1016 - Romanos, et al., "Foreign Gene Expression in Yeast: a Review"

Ex. 1018- Kemme, et al., "The impact of microbial phytase on the nutrition of monogastrics and the environment"

Ex. 2021 - Prosecution of U.S. Application No. 09/104,769 leading to U.S. Patent No. 6,451,572 [PART 2 of 2]

Ex. 1022 - Prosecution of U.S. Application No. 10/094,693 leading to U.S. Patent No. 7,026,150 [PART 2 of 2]

Ex. 1023 - Prosecution of U.S. Application No. 11/372,851 leading to U.S. Patent No. 7,312,063 [PART 1 of 2]

Ex. 1023 - Prosecution of U.S. Application No. 11/372,851 leading to U.S. Patent No. 7,312,063 [PART 2 of 2]

Ex. 1005 - Olsen, et al., "Improvement of Bacterial B-Glucanase Thermostability by Glycosylation"

Ex. 1007 - Greiner, et al., "Purification and Characterization of Two Phytases from Escherichia coli"

Ex. 1011 - Ostanin, et al., "Asp304 of Escherichia coli Acid Phosphatase Is Involved in Leaving Group Protonation"

Ex. 1013 - Stryer, Biochemistry

Ex. 1014 - Escherichia coli periplasmic phosphoanhydride phosphohydrolase (appA) gene, complete cds

Ex. 1015 - Greiner, et al., "Characterization of a Phytase from Escherichia coli"

Ex. 1017 - Romanos, "Advances in the use of Pichia pastoris for high-level gene expression"

Ex. 1019 - International Application Publication No. WO 98/06856 to Apajalahti, et. al

Ex. 2021 - Prosecution of U.S. Application No. 09/104,769 leading to U.S. Patent No. 6,451,572 [PART 1 of 2]

Ex. 1022 - Prosecution of U.S. Application No. 10/094,693 leading to U.S. Patent No. 7,026,150 [PART 1 of 2]

Ex. 1025 - Prosecution of U.S. Application No. 12/941,445 leading to U.S. Patent No. 8,455,232 [PART 4 of 4]

Ex. 1024 - Prosecution of U.S. Application No. 11/962,446 leading to U.S. Patent No. 7,829,318

Ex. 1025 - Prosecution of U.S. Application No. 12/941,445 leading to U.S. Patent No. 8,455,232 [PART 1 of 4]

Ex. 1025 - Prosecution of U.S. Application No. 12/941,445 leading to U.S. Patent No. 8,455,232 [PART 2 of 4]

Ex. 1025 - Prosecution of U.S. Application No. 12/941,445 leading to U.S. Patent No. 8,455,232 [PART 3 of 4]

Ex. 1026 - Prosecution of U.S. Application No. 13/897,172 leading to U.S. Patent No. 8,993,300

Ex. 1027 - Meldgaard et al., "Different Effects of N-Glycosylation on the Thermostability of Highly Homologous Bacterial (1,3-1,4)-Beta-Glucanases Secreted from Yeast"

Ex. 1031 - Proof of Service on ABITEC Corporation, Huvepharma EOOD v. Associated British Foods, plc, No. 1:18-cv-00129 (D. Del. 2018)

Ex. 1033 - Joint Claim Construction Statement, Huvepharma EOOD v. Associated British Foods, plc, No. 1:18-cv-00129 (D. Del. 2018)

Ex. 1030 - Proof of Service on AB Vista, Inc., Huvepharma EOOD v. Associated British Foods, plc, No. 1:18-cv-00129 (D. Del. 2018)

Ex. 1032 - Proof of Service on AB Enzymes, Inc., Huvepharma EOOD v. Associated British Foods, plc, No. 1:18-cv-00129 (D. Del. 2018)

Petitioner Power of Attorney

Ex. 1001 - US Patent No. 7,312,063 to Lei

Ex. 1002 - Declaration of Dan Robertson

Ex. 1020 - Declaration of Sylvia D. Hall-Ellis, Ph.D. [Part 1 of 2]

Ex. 1020 - Declaration of Sylvia D. Hall-Ellis, Ph.D. [Part 2 of 2]

Petition for Inter Partes Review